Synthesis and characterization of a novel series of benzenesulfonylurea and thiourea derivatives of 2H-pyran and 2H-pyridine-2-ones as antibacterial, antimycobacterial and antifungal agents

Faidallah, Hassan M.; Khan, Khalid Ali; Asiri, Abdullah M.

doi:10.5155/eurjchem.2.2.243-250.257

Cited by 21 publications

(5 citation statements)

References 37 publications

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“…This modification has been found to be responsible for virulence in Staphylococcus aureus (Pasquina et al, 2016). Several compounds containing pyran rings have been tested for their microbiocide properties (Rajan et al, 2017) and derivatives of 2H-pyran (thiourea and benzene sulfonylurea) possess antimicrobial activities (Faidallah et al, 2011). Carboxamides are not only being used as site-specific fungicides (Jangir et al, 2018) but have also been shown to possess antibacterial properties (Jeong and Moloney, 2013).…”

Section: Discussionmentioning

confidence: 99%

Evidence of Biocontrol Activity of Bioinoculants Against a Human Pathogen, Listeria monocytogenes

et al. 2020

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Section: Discussionmentioning

confidence: 99%

Evidence of Biocontrol Activity of Bioinoculants Against a Human Pathogen, Listeria monocytogenes

et al. 2020

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“…Faidallah et al synthesized some new DHA‐based hydrazones and evaluated their antimicrobial potential toward various bacterial and fungal strains. [ 82 ] Among all the newly derived compounds, 57 showed the most significant antimicrobial activity toward the tested strains with a MIC value of 12.5 µg/mL against S. aureus and 25 µg/mL against C. albicans . SAR studies revealed that the urea moiety present in the complex led to enhanced inhibitory activity.…”

Section: Biological Activities Of Dha‐based Compoundsmentioning

confidence: 99%

Dehydroacetic acid a privileged medicinal scaffold: A concise review

Grover,

Kumar,

Tittal

et al. 2023

Archiv der Pharmazie

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From the last decade, research on dehydroacetic acid (DHA) and its derivatives has increased immensely due to its significant role in various fields, including medicine, cosmetics, food industry, and so on. In the medicinal area, DHA plays an essential role in developing novel action‐based drugs, which are helpful for treating various diseases. Besides its plethora of biological applications, its chelating ability offers the easiest synthetic route for synthesizing more active metal complexes. DHA derivatives along with their metal complexes show a number of biological activities and also exhibit various interactions with multiple biological targets. This article summarizes recent medicinal applications (2000‐onwards) of DHA‐based compounds and their analogs, along with their structure–activity relationship (SAR) analysis. Their interactions with different target enzymes are also discussed. This information derived from SAR analysis would be helpful for medicinal chemists working on the development of drugs based on heterocyclic frameworks, particularly those based on the DHA scaffold.

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“… 15 − 17 Antimicrobial and fungicidal activities are also attributed to sulfonylurea compounds. 18 Sulfonylthioureas (STUs) are also purported to have insecticidal activities 19 and anticonvulsant properties. 20 …”

Section: Introductionmentioning

confidence: 99%

“…(Figure A) . They are also used widely as herbicides, antihelminthics, and acaricides. − Antimicrobial and fungicidal activities are also attributed to sulfonylurea compounds . Sulfonylthioureas (STUs) are also purported to have insecticidal activities and anticonvulsant properties …”

Section: Introductionmentioning

confidence: 99%

One-Pot Synthesis of Thio-Augmented Sulfonylureas via a Modified Bunte’s Reaction

et al. 2022

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We report the development of a one-pot Bunte’s reaction-enabled expeditious platform under aqueous conditions for the scalable conversion of sulfonylureas to synthetically versatile thio-sulfonylureas. The reaction was further propagated in the same pot to yield diverse chiral and achiral isothiosulfonyl analogs. The protocol enabled the synthesis of various drug-like molecules and was applied to an enantiomeric synthesis of a cannabinoid receptor antagonist SLV326.

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Synthesis and characterization of a novel series of benzenesulfonylurea and thiourea derivatives of 2H-pyran and 2H-pyridine-2-ones as antibacterial, antimycobacterial and antifungal agents

Cited by 21 publications

References 37 publications

Evidence of Biocontrol Activity of Bioinoculants Against a Human Pathogen, Listeria monocytogenes

Evidence of Biocontrol Activity of Bioinoculants Against a Human Pathogen, Listeria monocytogenes

Dehydroacetic acid a privileged medicinal scaffold: A concise review

One-Pot Synthesis of Thio-Augmented Sulfonylureas via a Modified Bunte’s Reaction

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