In vitro antimicrobial activity of triterpenoid saponin from Tephrosia purpurea seeds extract

Khan, Noor Afshan

doi:10.5155/eurjchem.2.2.189-192.239

Cited by 5 publications

(1 citation statement)

References 20 publications

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“…The terpenes and phenols also exhibit antimicrobial properties (Shabir, 2011). The antimicrobial potential of triterpinoid saponins and lignans are also found in recent studies (Khan, 2011;Vasilev, 2005). The significant antimicrobial properties observed in this screening may be due to the presence of one of these phytochemicals in the ethanolic extract of the J. neesii.…”

Section: Discussionmentioning

confidence: 68%

Antimicrobial activity of ethanolic extracts of <i>Justicia neesii</i>

Sridhar¹,

Duggirala²,

Puchchakayala³

2014

Bangladesh J Pharmacol

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Section: Discussionmentioning

confidence: 68%

Antimicrobial activity of ethanolic extracts of <i>Justicia neesii</i>

Sridhar¹,

Duggirala²,

Puchchakayala³

2014

Bangladesh J Pharmacol

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A comprehensive review on ethnomedicine, phytochemistry, pharmacology, and toxicity of Tephrosia purpurea (L.) Pers.

Rao

Yadav

Singh

et al. 2020

Phytotherapy Research

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Tephrosia purpurea (L.) Pers. is a well‐known plant in Ayurveda and named “Sarwa wranvishapaka” for its property to heal wounds. Traditionally, it is practiced for impotency, asthma, dyspepsia, hemorrhoids, syphilis gonorrhea, rheumatism, enlargement of kidney and spleen. It is an important component of herbal preparations like Tephroli and Yakrifti used to cure liver disorders. Various phytocompounds including pongamol, purpurin, purpurenone, tephrosin, bulnesol, tephrostachin, β‐sitosterol, and so on have been reported. Modern pharmacological studies have shown that the plant have wound healing, antileishmanial, anticarcinogenic, antimicrobial, antioxidant, hepatoprotective, antifertility, antispermatogenic, anti‐diarrheal, diuretic, and insecticidal properties. Acetylcholinesterase inhibitory action reported from this plant aids its utilization for the development of drugs for Alzheimer's and dementia neurological disorders. Among the known active compounds of T. purpurea, tephrostachin is responsible for antiplasmodial activity, tephrosin, pongaglabol, and semiglabrin exerts antiulcer activity while quercetin, rutin, β‐sitosterol, and lupeol are mainly responsible for its anti‐inflammatory and anti‐cancer properties. From different toxicological studies, concentrations up to 2,000 mg/kg were considered safe. The present review comprehensively summarizes the ethnomedicine, phytochemistry, pharmacology, and toxicology of T. purpurea. Further research on elucidation of the structure–function relationship among active compounds, understanding of multi‐target network pharmacology and clinical applications will intensify its therapeutic potential.

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