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Cited by 8 publications
(3 citation statements)
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References 16 publications
(18 reference statements)
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“…PEG is hydrophilic and relatively inert polymer that when incorporated in the nanoparticle surface, hinders the binding of plasma proteins (opsonization), and thus preventing substantial loss of the given dose. PEGylated nanoparticles are often referred as “stealth” nanoparticles, because without opsonization, they remain undetected by the reticuloendothelial system (RES) (Li and Huang, 2010, Angra et al, 2011). By creating polymer complexes, clearance issues have been addressed, but aggregation is still a concern with small particles due to large surface area.…”
Section: Characteristics Of Nanoparticle Drug Formulationsmentioning
confidence: 99%
“…PEG is hydrophilic and relatively inert polymer that when incorporated in the nanoparticle surface, hinders the binding of plasma proteins (opsonization), and thus preventing substantial loss of the given dose. PEGylated nanoparticles are often referred as “stealth” nanoparticles, because without opsonization, they remain undetected by the reticuloendothelial system (RES) (Li and Huang, 2010, Angra et al, 2011). By creating polymer complexes, clearance issues have been addressed, but aggregation is still a concern with small particles due to large surface area.…”
Section: Characteristics Of Nanoparticle Drug Formulationsmentioning
confidence: 99%
“…Another obstacle with smaller nanoparticles is their aggregation tendency. For instance, smaller size of micelles, dendrimers, and QDs are inclined to aggregation that results in poor biodistribution [256][257][258][259]. Although surface functionalization with PEG is a very effective method for reducing accumulation in non-target organs, these nanoparticles are often referred to as "stealth" nanoparticles because they can elude from the phagocytic system and may provoke cellular toxicity [260].…”
Section: Limitations and Disadvantages Of Therapeutic Nanoparticlesmentioning
confidence: 99%
“…Drugs can be made into nano-suspensions of particles with diameters less than 100 nanometers (nm) [15][16][17][18]. Nano-sized compounds are used to improve solubility of poorly-water-soluble compounds and are sub-micron sized colloidal dispersions of pure drug particles in an outer liquid phase.…”
Section: Nano-suspensionmentioning
confidence: 99%