2021
DOI: 10.5155/eurjchem.12.3.323-328.2134
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Abstract: This study reports an organic salt prepared from an antibacterial drug, levofloxacin and antioxidant γ-resorcylic acid. A simple preparation method leads to a crystal with disordered structure. The idea is to prepare an organic salt comprising of pharmaceutically acceptable acidic and basic components. The salt is characterised by IR, solid state NMR, and single crystal XRD. Crystal data for C25H26N3O8F: triclinic, space group P-1 (no. 2), a = 7.0037(8) Å, b = 12.764(3) Å, c = 13.909(3) Å, α = 104.821(4)°, β =… Show more

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Cited by 3 publications
(2 citation statements)
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References 15 publications
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“…In salt 1, the 1H-benzo S17). The further stablization of the crystal packing in salt 1 is due to offset π•••π stacking interactions with intercentroid separation range from 3.4725 (9) The water molecule plays an important role as it is connected with cations and anions through O−H•••O bonding (Figure 3, Table S17). The further stablization of the crystal packing of salt 2 is due to C−O•••π interaction (Table 2) and the offset π•••π stacking interactions with intercentroid separation range from 3.7016 (12) Antioxidant (DPPH) Assay.…”
Section: ■ Results and Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…In salt 1, the 1H-benzo S17). The further stablization of the crystal packing in salt 1 is due to offset π•••π stacking interactions with intercentroid separation range from 3.4725 (9) The water molecule plays an important role as it is connected with cations and anions through O−H•••O bonding (Figure 3, Table S17). The further stablization of the crystal packing of salt 2 is due to C−O•••π interaction (Table 2) and the offset π•••π stacking interactions with intercentroid separation range from 3.7016 (12) Antioxidant (DPPH) Assay.…”
Section: ■ Results and Discussionmentioning
confidence: 99%
“…About half of the marketed drugs are in salt form with stoichiometric anionic and cationic ratio. Normally, higher bioavailability is associated with salt forms, and for complementary ions, a p K a difference of ≥3 is expected for formation of salts. , Pharmaceutical organic salt is an important solid-state form of drugs having impacts during the drug development process. Heterocyclic aromatic compounds are important pharmacophores due to their promising applications in medicine.…”
Section: Introductionmentioning
confidence: 99%