Spectrum subtraction method for simultaneous determination of acetaminophen and caffeine in panadol extra dosage forms

Sebaiy, Mahmoud M.; Mattar, Amr A.

doi:10.5155/eurjchem.11.1.80-83.1956

Cited by 3 publications

(2 citation statements)

References 25 publications

(19 reference statements)

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“…8 synthetic mixtures in the same range of calibration set of the three drugs were also prepared as a validation set according to the multifactor and the multilevel design [11] in 10 mL volumetric asks to evaluate the accuracy and precision of the constructed models.…”

Section: Prediction Setmentioning

confidence: 99%

UV-Chemometric Method Development for Resolving The Overlapped Spectra of Aspirin, Caffeine and Orphenadrine Citrate in Their Ternary Pharmaceutical Dosage Form

Sebaiy

Mattar

El-Adl

2022

Preprint

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A simple, specific, accurate and precise UV-chemometric methods have been developed for the analysis of aspirin, caffeine and orphenadrine citrate in their ternary mixture form without prior separation. CLS, PLS and PCR were developed for simultaneous determination of the three drugs together by using different sets of data in which better results were produced. Unfortunately, PLS method was the only method which was able to determine them accurately. The validity of these chemometric methods has been carried out by 8 synthetic mixtures for determination of the power of prediction for each method. Latent variable number is different from one model to another with changing the set of data. Predicted residual error sum of squares (PRESS) and root mean square error of prediction (RMSEP) were used for comparison between different methods and for determination the predictive power of each set of data. In addition, statistical comparison between the proposed chemometric methods was performed.

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Section: Prediction Setmentioning

confidence: 99%

UV-Chemometric Method Development for Resolving The Overlapped Spectra of Aspirin, Caffeine and Orphenadrine Citrate in Their Ternary Pharmaceutical Dosage Form

Sebaiy

Mattar

El-Adl

2022

Preprint

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“…An extensive literature search revealed various analytical approaches for the simultaneous determination (SMD) of caffeine and paracetamol in commercial formulations and biological fluids. For the SMD of caffeine and paracetamol in commercial formulations, different spectrometry techniques involving various chemical procedures, such as derivatization have been used [5][6][7][8][9][10]. For the SMD of caffeine and paracetamol in various commercial dosage forms, several high-performance liquid chromatography (HPLC) techniques have been used [4,[11][12][13][14][15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Determination of Caffeine and Paracetamol in Commercial Formulations Using Greener Normal-Phase and Reversed-Phase HPTLC Methods: A Contrast of Validation Parameters

et al. 2022

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There has been no assessment of the greenness of the described analytical techniques for the simultaneous determination (SMD) of caffeine and paracetamol. As a result, in comparison to the greener normal-phase high-performance thin-layer chromatography (HPTLC) technique, this research was conducted to develop a rapid, sensitive, and greener reversed-phase HPTLC approach for the SMD of caffeine and paracetamol in commercial formulations. The greenness of both techniques was calculated using the AGREE method. For the SMD of caffeine and paracetamol, the greener normal-phase and reversed-phase HPTLC methods were linear in the 50–500 ng/band and 25–800 ng/band ranges, respectively. For the SMD of caffeine and paracetamol, the greener reversed-phase HPTLC approach was more sensitive, accurate, precise, and robust than the greener normal-phase HPTLC technique. For the SMD of caffeine paracetamol in commercial PANEXT and SAFEXT tablets, the greener reversed-phase HPTLC technique was superior to the greener normal-phase HPTLC approach. The AGREE scores for the greener normal-phase and reversed-phase HPTLC approaches were estimated as 0.81 and 0.83, respectively, indicated excellent greenness profiles for both analytical approaches. The greener reversed-phase HPTLC approach is judged superior to the greener normal-phase HPTLC approach based on numerous validation parameters and pharmaceutical assays.

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Simultaneous estimation of ibuprofen, caffeine, and paracetamol in commercial products using a green reverse-phase HPTLC method

Alqarni,

Shakeel,

Alshehri

et al. 2024

Green Processing and Synthesis

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A fast, sensitive, and green reverse-phase “high-performance thin-layer chromatography” approach for the simultaneous estimation of ibuprofen (IBF), caffeine (CAF), and paracetamol (PCM) in marketed formulations was established and verified in this study. The binary combination of acetone and water (80:20 v/v) was used as the green eluent system. The current method’s greenness was predicted using four different approaches, namely National Environmental Method Index, Analytical Eco-Score (89), ChlorTox (1.08 g), and the Analytical GREENness (83) approaches, which demonstrated an outstanding greener profile. The present approach was linear in the range of 25–800 ng·band−1 for the simultaneous estimation of IBF, CAF, and PCM. In addition, the current method was accurate (% recoveries = 100 ± 2), precise (%CV < 2%), robust (%CV < 2), sensitive (LOD = 1.13–2.71 ng·band−1 and LOQ = 3.39–8.10 ng·band−1), and green. The amount of IBF, CAF, and PCM in commercial tablets was determined to be 99.51%, 98.25%, and 100.64%, respectively. The present method for the simultaneous determination of IBF, CAF, and PCM in marketed tablets is supported by these data. The findings of this study suggested that the current approach may be consistently applied to analyze IBF, CAF, and PCM in marketed tablets.

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Spectrum subtraction method for simultaneous determination of acetaminophen and caffeine in panadol extra dosage forms

Cited by 3 publications

References 25 publications

UV-Chemometric Method Development for Resolving The Overlapped Spectra of Aspirin, Caffeine and Orphenadrine Citrate in Their Ternary Pharmaceutical Dosage Form

UV-Chemometric Method Development for Resolving The Overlapped Spectra of Aspirin, Caffeine and Orphenadrine Citrate in Their Ternary Pharmaceutical Dosage Form

Simultaneous Determination of Caffeine and Paracetamol in Commercial Formulations Using Greener Normal-Phase and Reversed-Phase HPTLC Methods: A Contrast of Validation Parameters

Simultaneous estimation of ibuprofen, caffeine, and paracetamol in commercial products using a green reverse-phase HPTLC method

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