2019
DOI: 10.5155/eurjchem.10.1.30-36.1791
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Abstract: In the present study, a series of new pyrazoline derivatives bearing sulfanilamido moiety were synthesized and obtained in good yields. The chemical structures of the compounds were elucidated by spectral data (FT-IR, MS, UV-VIS and NMR). The synthesized compounds 41-70 were screened for their antimicrobial activity and compared with controls. The in vitro antibacterial activity of compounds 41-45 and 48-57 was checked against two Gram positive microorganisms (S. aureus and S. mutans) and three Gram negative m… Show more

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Cited by 11 publications
(6 citation statements)
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“…Moreover, the contrast compounds C-1 and C-2 were also smoothly synthesized through the reported cyclization and acylation routes from the corresponding materials (outlined in Scheme 4). 33,34 The structures of the novel target compounds I and II were confirmed through 1 H NMR, 13 C NMR, and HRMS analyses. Additionally, a colorless single crystal (0.14 × 0.12 × 0.12 mm) of compound IId was obtained and further determined by Xray diffraction.…”
Section: Resultsmentioning
confidence: 95%
See 1 more Smart Citation
“…Moreover, the contrast compounds C-1 and C-2 were also smoothly synthesized through the reported cyclization and acylation routes from the corresponding materials (outlined in Scheme 4). 33,34 The structures of the novel target compounds I and II were confirmed through 1 H NMR, 13 C NMR, and HRMS analyses. Additionally, a colorless single crystal (0.14 × 0.12 × 0.12 mm) of compound IId was obtained and further determined by Xray diffraction.…”
Section: Resultsmentioning
confidence: 95%
“…Synthetic Procedure for the Contrast Compounds C-1 and C-2. Referring to the procedure in literature, 33,34 the contrast compounds 2,2-dichloro-1-(3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)ethan-1-one (C-1) and 2,2-dichloro-1-(3,5-diphenyl-4,5-dihydro-1Hpyrazol-1-yl)ethan-1-one (C-2) were successfully synthesized.…”
Section: General Synthetic Procedures For the N-acyl Pyrazoline Targe...mentioning
confidence: 99%
“…It is worth noticing that joining two or more diverse heterocyclic rings into one structure may bring about new compounds with upgraded bioactivity . As an example, pyridines with the benzothiazole moiety have enhanced antibacterial and antifungal activities. , To achieve this goal, new strategies for synthesizing pyridine-bearing benzothiazole moieties have been generated. As a continuation of our previous work on the synthesis of bioactive heterocyclic ring systems, we herein report that the cytotoxic activity of some novel arylpyridines incorporated benzothiazole moieties 8a – h against H5N1, SARS-COV-2 viruses, and their inhibition of SARS-COV-2 main protease (M pro ). Molecular docking studies of more potent main protease inhibitors were also performed to find a potential candidate as antiviral agent toward H5N1 and SARS-CoV-2 viruses.…”
Section: Introductionmentioning
confidence: 77%
“…3-(4-Nitrophenyl)-1-phenylprop-2-en-1-one (1.265 g, 0.005 mol) was dissolved in ethanol (30 mL) and refluxed with hydrazine hydrate (0.501 g, 0.010 mol) for 8 h. After the reaction was complete, the reaction mixture was cooled and refrigerated overnight. The resulting solid was filtered, and the crude pyrazoline was dried and recrystallized from ethanol …”
Section: Methodsmentioning
confidence: 99%
“…The resulting solid was filtered, and the crude pyrazoline was dried and recrystallized from ethanol. 30 2.1. (3).…”
Section: Methodsmentioning
confidence: 99%