1,2,4-Triazine Chemistry Part II: Synthetic approaches for phosphorus containing 1,2,4-triazine derivatives

Abstract

KEYWORDSThis review represents the methods developed for the synthesis of phosphorus containing 1,2,4-triazine moieties. These methods depends on the phosphorylation of side functional groups of 1,2,4-triazines and cyclization of side functional groups of 1,2,4-triazines with phosphorus reagents to give isolated and fused phosphorus heterocyclic systems.

1,2,4-Triazine Chemistry Part IV: Synthesis and Chemical Behavior of 3-Functionalized 5,6-Diphenyl-1,2,4-triazines towards Some Nucleophilic and Electrophilic Reagents

“…Literature reveals that there are few review articles illustrated the chemical reactivity of 1,2,4‐triazines . In continuation of our work in these area , this review article reports synthesis and chemical behavior of 3‐functionalized 5,6‐diphenyl‐1,2,4‐triazines towards some electrophilic and nucleophilic reagents.…”

Synthesis and Chemistry of Phosphorus Compounds Substituted by 1,2,4-Triazine Moieties as Medicinal Probes

“…Different isomers of triazaphospholes have multiple medicinal properties, as antibacterial, 20 anti-breast, anticolonial, and anti-prostate carcinoma cell lines 21 activity. Abdel-Rahman et al [22][23][24][25][26] reported many reviews in the field of phosphorus-1,2,4-triazines, including synthesis, chemistry, and their specific biological properties. Based on these facts, the present review reports significant attempts to synthesize phosphorus-containing 1,2,4-triazine compounds as well as their physical, chemical, and biological properties.…”

Ultrasound Synthesis of Benzimidazolo-1,3,5-Triazine Derivatives and Their Anti-Histamine and Anti-Diabetic Activities

“…Also, they are known for their wide range of applications on pharmacology as an analgesic 1 , antibacterial 2 , anticonvulsant 3,4 , antifungal 5 , antihistaminic 6 , anti-inflammatory 7 , anticancer 8 , antihypertensive, antineuropathic 9 etc. A benzimidazole moiety represents an important pharmacophore of selection for establishing anti-inflammatory, analgesic molecules and has a privileged structure in medicinal chemistry 10 . Substituted benzimidazole at the positions 1 and 2 shows a powerful antioxidant activity [11][12][13] .…”