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Cited by 3 publications
(4 citation statements)
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“…Herein, we described the detailed steps adopted for the synthesis of 4‐(3,4‐dimethoxyphenyl)‐4 H ‐chromene derivatives 1–20 (Schemes 1–4). Condensation of 3,4‐dimethoxybenzaldehyde and resorcinol with the active methylene group of malononitrile and ethyl cyanoacetate gave the appropriate starting precursors namely o ‐aminocyano chromene 1 (Madkour et al, 2008) and o ‐aminoester chromene 2 (Carr et al, 2020), sequentially (Scheme 1).…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Herein, we described the detailed steps adopted for the synthesis of 4‐(3,4‐dimethoxyphenyl)‐4 H ‐chromene derivatives 1–20 (Schemes 1–4). Condensation of 3,4‐dimethoxybenzaldehyde and resorcinol with the active methylene group of malononitrile and ethyl cyanoacetate gave the appropriate starting precursors namely o ‐aminocyano chromene 1 (Madkour et al, 2008) and o ‐aminoester chromene 2 (Carr et al, 2020), sequentially (Scheme 1).…”
Section: Resultsmentioning
confidence: 99%
“…Then, redocking of the ligand inside the c-Src kinase enzyme binding site was done to determine RMSD and validate the study. Finally, the most potent chromenopyrimidine 5 was docked inside the c-Src kinase enzyme active site to determine its binding pattern.3 | RESULTS AND DISCUSSION3.1 | ChemistryHerein, we described the detailed steps adopted for the synthesis of 4-(3,4-dimethoxyphenyl)-4H-chromene derivatives 1-20 (Schemes 1-4).Condensation of 3,4-dimethoxybenzaldehyde and resorcinol with the active methylene group of malononitrile and ethyl cyanoacetate gave the appropriate starting precursors namely o-aminocyano chromene 1(Madkour et al, 2008) and o-aminoester chromene 2 (Carr et al, 2020), sequentially (Scheme 1). Reaction of 2-amino-4-(3,4-dimethoxyphenyl)-7-hydroxy-4Hchromene-3-carbonitrile (1) with excess triethyl orthoformate containing glacial acetic acid gave chromene formimidate 3.…”
mentioning
confidence: 99%
“…As a continuation of our previous work 2,20,21,25,26 on the utility of activated nitriles in the synthesis of a wide variety of heterocyclic systems, in this work we aimed to design and construct pyrimidine derivatives from relatively simple starting materials. Thus,3]dioxol-5-yl)-4-oxo-2-thioxo-1,2,3,4tetrahydropyrimidine-5-carbonitrile (1) was prepared by condensation of thiourea with ethyl 3-(benzo [d][1,3]dioxol-5yl)-2-cyanoacrylate in refluxing ethanol.…”
Section: Resultsmentioning
confidence: 99%
“…In connection with our program aiming at the synthesis and biological evaluation of fused heterocycles , the authors' target, herein, was the preparation of furo[2,3‐ b ]pyridine, 1,2‐dihydropyrido[2,3‐ e ][1,3,4]thiadiazepine‐3(5 H )‐thione, and pyrido[2,1‐ c ][1,2,4]triazine. The key starting material 4‐(furan‐2‐yl)‐6‐(naphthalen‐1‐yl)‐2‐oxo‐1,2‐dihydropyridine‐3‐carbonitrile ( 1 ) has been synthesized via one‐pot multi‐component reaction of 1‐acetylnaphthalene, furfural, ethyl cyanoacetate, and ammonium acetate in ethanol.…”
Section: Resultsmentioning
confidence: 99%