1,2,4-Triazine Chemistry Part I: Orientation of cyclization reactions of functionalized 1,2,4-triazine derivatives

Synthesis of New Heterocyclic Nitrogen System Bearing Thiazolopyrazole Moiety as New Biocidal Agents

“…Abdel-Rahman et al [10] synthesized various 1,2,4-triazine derivatives as pharmacological, medicinal and antimicrobial agents based upon these results 2-(3′-phenyl-6′-oxo-5′-arylidene- (11) was synthesized from the interaction between compound 3 with oxazol-5-one (9) in aqueous ethanol to give the acid hydrazide 10 followed by ring closure reaction in warmed aqueous K2CO3 (Scheme-IV).…”

“…On the other hand, pyrazoles showed a very important medicinal and pharmacological properties [4]. Various heterocyclic nitrogen systems such as phathalazine [5] and 1,2,4-triazine derivatives reported as antimicrobial, anti HIV, anticancer and molluscicidal agents against snail [6][7][8][9][10]. Upon these observations, the present work tends to combination of these heterocyclic in one novel systems in view of their antibacterial in the compare with antibiotics.…”

Synthesis of Novel Heteropolycyclic Nitrogen Systems Bearing Fluorine Substituted Pyrazolo[3,4-d] Pyrimidine Derived from Polyfunctional π-Acceptor Compounds and Guanidine as Fungicidal Probes

“…In addition, introduction fluorine atoms to pyrazolopyrimidine enhance and improve their pharmacological properties [8] [9]. Abdel Rahman et al [10] [11] [12], reported that the orientation of cyclization reactions of functionalized amino and/or hydrazine bearing heterocyclic moieties depends on the effect of substituents, solvent pH, temper-International Journal of Organic Chemistry ature, chemoselective orientation heterocycleization and regioselectivity of electrocyclization as well as preferring the cite of closure as this work focused on N'-heteroaryl guanidine 4 as electron donors towards various electron-acceptors reagents in view of their fungicidal effects.…”

Regioselective Green Synthesis and Antimicrobial properties of full fused non mixed Heterocyclic Systems

“…1,2,4-Triazines play an essential task in various biological routes and in synthesis of drugs. Therefore, a lot of heterocyclic systems attitude 1,2,4triazines are found to have significant pharmacological effects [6][7][8][9][10][11][12][13] . That targets have anti-AIDS 14,15 , antiviral 16 , anticancer [17][18][19][20] , antimicrobial [21][22][23][24] , antitumor 25 , antithelmintic drugs 26 .…”