Synthesis, spectroscopic characterization, crystal structure and pharmacological properties of some novel thiophene-thiourea core derivatives

Abstract

KEYWORDSThis article presents our research concerning the synthesis of new thiophene-thiourea derivatives (1-12) and their pharmacological properties. These novel thiophene-thiourea derivatives were synthesized and characterized by IR, 1 H and 13 C NMR spectroscopy, mass spectrometry and elemental analysis. The crystal structure of N,N-diphenyl-N'-(thiophene-2carbonyl)-thiourea was determined from single crystal X-ray diffraction data. It crystallizes in the monoclinic space group P21 with unit cell dimensions of a=11.7469(5) Å, b=6.0849(2) Å, c=12.5792(6) Å, β= 117.736(7) ° and V = 795.8(6) Å 3 . The mass fragmentation pattern has also been discussed. The synthesized compounds were screened for their in vitro antifungal activities against the standard strains: C. Albicans, C. Glabrata, and C. Tropicalis. The compounds N-

Crystal and molecular structure of bis(4-bromo-N-(diethylcarbamothioyl)benzamido)nickel(II) complex

“…Many benzoylthiourea compounds have been tested for their in vitro activity against a large variety of tumor lines and have been found to be as effective or better than traditional heavy metal anticancer drugs such as cis-platin [1]. Some acylthiourea derivatives exhibit antiviral [2], antibacterial [3], antifungal [4], antihelmintic [5,6], herbicidal [7], activities. 1,3-Dialkyl or diaryl thioureas exhibit significant antifungal activity against plant pathogens Pyricularia oryzae and Drechslera oryzae [8].…”

Bioactive Lignan Constituents from the Twigs of <i>Lindera glauca</i>

“…Increased lipophilicity of molecules was reported to be responsible for enhanced cytotoxicity. 21) Of these compounds, compound 3 possessing two feruloyl groups and the methoxy group at C-4, showed the most potent cytotoxicity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines with IC 50 values of 21.72, 9.83, 14.36, and 7.79 µM, respectively. On the basis of the expanded understanding that inflammation plays a crucial role in tumor progression, we also evaluated anti-inflammatory activities of the isolates 1-6 in the medium using murine microglia BV-2 cells.…”

N-(Dibenzylcarbamothioyl)-3-methylbutanamide: Crystal structure, Hirshfeld surfaces and antimicrobial activity

“…These ligands exhibit prevalent coordination systems such as neutral bidentate and monobasic bridging in some complexes [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]. Since the structural and conformational properties of acyl thioureas has been recognized, the use of transition metal complexes, including acylthiourea ligands, have been expanded in many different fields [9][10][11][12].…”