Synthesis, characterization and crystal structure of 1-(4-methylbenzoyl)-3-(4 aminosulfonylphenyl)thiourea

Abstract

KEYWORDSAn efficient synthesis of the title compound, 1-(4-methylbenzoyl)-3-(4-aminosulfonyl phenyl)thiourea, was carried out by reaction of 4-methylbenzoyl chloride with potassium thiocyanate in acetone to afford 4-methylbenzoyl isothiocyanate in situ followed by treatment with sulfanilamide. The structure was confirmed by spectroscopic data and elemental analyses. The molecular structure was determined from single crystal X-ray diffraction data. It crystallizes in the monoclinic space group P21/n with unit cell dimensions of a = 4.8116 (9)

Synthesis and Characterization of Novel Thiourea Derivatives and Their Nickel and Copper Complexes

“…FT-IR spectra were taken with KBr pellets between 4000 and 400 cm −1 . In the FT-IR spectra of the synthesized benzoylthiourea derivatives show sharp and strong absorption band at 3231, 3293, 3271, 3166, and 3159 cm −1 for HL 1 , HL 2 , HL 3 , HL 4 , and HL 5 attributed to the stretching vibration of N-H group, respectively [11,12,21,22,[24][25][26][27][28].…”

“…Some derivatives are biologically active, such as antifungal [6,7], antitumour [8][9][10], antiviral, antibacterial [11][12][13], pharmacological [14], herbicidal, and insecticidal properties [11][12][13]. In addition, some of the research groups have reported thermal behaviour [15][16][17][18] and the acidity constants [19] of ligands of some benzoylthiourea derivatives and their metal complexes [20][21][22][23][24][25][26][27][28][29][30].…”

N-(Dibenzylcarbamothioyl)-3-methylbutanamide: Crystal structure, Hirshfeld surfaces and antimicrobial activity

“…These ligands exhibit prevalent coordination systems such as neutral bidentate and monobasic bridging in some complexes [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]. Since the structural and conformational properties of acyl thioureas has been recognized, the use of transition metal complexes, including acylthiourea ligands, have been expanded in many different fields [9][10][11][12].…”

Thermomechanical studies of thermally stable metal-containing epoxy polymers from diglycidyl ether of bisphenol A and amino-thiourea metal complexes

“…The structure of the free ligand HL is shown in Figure 1 [24][25][26][27][28][29][30][31][32]. The nickel and copper complexes were synthesized by a two-pot reaction.…”