Synthesis and studying the antitumor activity of novel 5-(2-methylbenzimidazol-5-yl)-1,3,4-oxadiazole-2(3H)-thiones

Synthesis and Biological Evaluation of Some 1,2‐Disubstituted Benzimidazole Derivatives as New Potential Anticancer Agents

“…Chemistry Target molecules (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18) were synthesized in three steps as shown in Scheme 1. In the first step, 2-(chloromethyl)benzimidazole (1) benzimidazole (2) was obtained from 2-(chloromethyl)benzimidazole (1) via Willgerodt-Kindler reaction.…”

“…In this study, unlike classical procedures, we used benzylic structure (1) as a starting material instead of aryl, alkyl ketone to obtain the thioamide structure [29]. Finally, 1H-2-[(morpholine-4yl)thioxomethyl]benzimidazole (2) was reacted with appropriate a-bromoacetophenone derivatives via bimolecular nucleophilic substitution (S N 2) reaction to give the intended 1-(2-aryl-2-oxoethyl)-2-[(morpholine-4-yl)thioxomethyl]benzimidazole derivatives (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). Finally, 1H-2-[(morpholine-4yl)thioxomethyl]benzimidazole (2) was reacted with appropriate a-bromoacetophenone derivatives via bimolecular nucleophilic substitution (S N 2) reaction to give the intended 1-(2-aryl-2-oxoethyl)-2-[(morpholine-4-yl)thioxomethyl]benzimidazole derivatives (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18).…”

“…Cytotoxic properties of the 1-(2-aryl-2-oxoethyl)-2-[(morpholine-4-yl)thioxomethyl]benzimidazole derivatives (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18) varied according to the substituents on the phenyl ring. In general, compounds 3,5,8,9,14, and 18 were the most cytotoxic molecules.…”

Synthesis and Characterization Platinum (II), Palladium (II) and Nickel (II) Complexes with some Heterocyclic Ligand of 1,3,4-Oxadazole Derivative

“…The infrared spectrum of APOD showed bands in the range (3396-3269) cm -1 , which are corresponding to ν(NH) of amine group (Galal et al, 2010;Tomi, 2012). A shifted with change in shape were observed from these bands, while increasing in intensity were noticed.…”

One pot synthesis of 1-((1-aryl-1H-1,2,3-triazol-4-yl)methyl)-1H-benzo[d] imidazoles in ionic liquids: Evaluation of antioxidant and antimicrobial activities

“…The benzimidazole has been an important pharmacophore and privileged structure, encompassing a diverse range of their biological properties [1,2]. Benzimidazoles have been reported as antimicrobial [3][4][5][6][7][8][9][10], antiviral [11][12][13][14], antioxidant [15], anti-inflammatory [16,17], antitumor [18] and anticancer agents [19][20][21]. 1,2,3-Triazoles due to their exclusive chemical and structural properties, have acknowledged a lot of awareness over the past decades and found extensive applications in medicinal chemistry [22][23][24][25], biological activities such as anti-HIV [27] and antimicrobial [27,28].…”