Synthesis and antimicrobial activity of some new 1,3-thiazoles, 1,3,4-thiadiazoles, 1,2,4-triazoles and 1,3-thiazines incorporating acridine and 1,2,3,4-tetrahydroacridine moieties

Synthesis of some pyridyl and cyclohexyl substituted 1,2,4 triazole, 1,3,4-thiadiazole and 1,3,4-oxadiazole derivatives

“…Moreover, the mercapto-and thione-substituted 1,2,4-triazole ring systems have been well studied and a variety of biological activities have been reported for a large number of their derivatives, such as antiproliferative [9], antimicrobial [10], antifungal [11], anticancer [12,13] properties. In addition, mercapto-1,2,4-triazoles are also of great utility to prepare other heterocyclic compounds [14][15][16].…”

2-((1E)-1-{2-[(2Z)-3,4-Diphenyl-2,3-dihydro-1,3-thiazol-2-ylidene]hydrazin-1-ylidene}ethyl)pyridin-1-ium bromide monohydrate

“…For the synthesis of thiazoles see: Zambon et al (2008); Franklin et al (2008); Karegoudar et al (2008); Ochiai et al (2003). For the biological significance of thiazole scaffold compounds, see: Masquelin & Obrecht (2001); Hirai et al (1980); Ali & El-Kazak (2010); Andreani et al (1996Andreani et al ( , 2008; Budriesi et al (2008); Walczynski et al (2005). For similar structures, see: Mague et al (2014); Mohamed et al (2013a,b).…”

“…1,3-Thiazole scaffold compounds are present in many pharmacologically active substances (Masquelin & Obrecht, 2001). They have found to possess strong antiinflammatory (Hirai et al, 1980), antimicrobial (Ali & El-Kazak, 2010), antitumor (Andreani et al, 2008) and selective cardiodepressant activities (Budriesi et al, 2008). Other compounds containing the thiazole ring have been reported as being histamine H3 antagonists (Walczynski et al, 2005) and herbicidals (Andreani et al, 1996).…”

Synthesis and cytotoxic activity against human tumor cells of heterocyclic systems derived from 2‐thioxo‐1,2‐dihydro‐4H‐3,1‐benzothazin‐4‐one

“…(2,4‐Dihydroxyphenyl)thieno‐1,3‐thiazin‐4‐one can be utilized to end lung, colon, and other type of cancer and it is nontoxic to normal body cells and organs . 1,3‐Thiazine derivatives are important intermediates in synthetic transformations . In relation to the aforementioned observations and facts the present work utilizes the proclivity of 2‐thioxobenzothazinone toward different electrophiles to design and construct a number of fused benzothiazinones, triazolobenzothiazinones, pyrazolobenzothiazinones, imidazolylbenzothiazinones with anticipated antiproliferative activity.…”