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Cited by 23 publications
(13 citation statements)
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“…The latter products 9 and 10 are assumed to be formed via initial S-alkylation of amino-thioxo derivative 4, followed by cyclocondensation in a fashion similar to established α-aminothione derivatizations [48][49][50]. By reaction of compound 4 with benzoic acid in the presence of phosphorus oxychloride we obtained the thiadiazole derivative 11 via dehydrative cyclization, in accordance with the findings of related reports [50][51][52][53]. Nevertheless, the outcome of reactions of compound 4 with various electrophilic reagents, as shown in Scheme 2, can be regarded as a rigorous proof for constitution of thienopyrimidin-4-one 4, locating the amino and thioxo groups in positions 3 and 2, respectively.…”
Section: Chemistrysupporting
confidence: 75%
“…The latter products 9 and 10 are assumed to be formed via initial S-alkylation of amino-thioxo derivative 4, followed by cyclocondensation in a fashion similar to established α-aminothione derivatizations [48][49][50]. By reaction of compound 4 with benzoic acid in the presence of phosphorus oxychloride we obtained the thiadiazole derivative 11 via dehydrative cyclization, in accordance with the findings of related reports [50][51][52][53]. Nevertheless, the outcome of reactions of compound 4 with various electrophilic reagents, as shown in Scheme 2, can be regarded as a rigorous proof for constitution of thienopyrimidin-4-one 4, locating the amino and thioxo groups in positions 3 and 2, respectively.…”
Section: Chemistrysupporting
confidence: 75%
“…In addition, mercapto-1,2,4-triazoles are also of great utility to prepare other heterocyclic compounds [14][15][16].…”
Section: Introductionmentioning
confidence: 99%
“…Nowadays, a lot of 1,2,4-triazole-based compounds have been extensively integrated into an array of therapeutic drugs and widely used in the clinic, namely; Triazolam (3), Alprazolam (4), Estazolam (5) (anticonvulsant and tranquilizer), [9] Itraconazole (6), Voriconazole (7), and Fluconazole (8) (antifungal), [10] Rizatriptan (9) (antimigraine agents) [11] Ribavirin (antiviral), [12] as well as Anastrozole (10) and Letrozole (11) (anticancer), [13] and so forth ( Figure 2). Numerous research articles focalized on synthesis and biological significance of 1, 2, 4-triazole derivatives as such as cytotoxic, [14] anticancer, [15] Antimycotic, [16] antimicrobial, [17] anti-inflammatory, [18] antihistamine, [19] antibacterial, [20] antihypertensive, [21] antimalarial, [22] analgesic, [23] and carbonic anhydrase inhibitors. [24] Food and Drug Administration (FDA) approved over 31 drug products containing 1,2,4-triazole scaffolds and more than 50 experimental drugs based on 1,2,4-triazole scaffolds.…”
Section: Introductionmentioning
confidence: 99%
“…[27] While 2,4-dihydro-4-(β-D-ribofuranosyl)-1,2,4(3H)-triazol-3-one (13) was obtained as an Actinomadura fermentation product. Both Essramycin (triazolopyrimidine) (14) and l-1,2,4-triazole-3-alanine (15) derived from Streptomyces strains are additionally obtained( Figure 3). [28] Presumable factors for researchers' enormous exploration of the 1,2,4-triazole scaffolds because of the triazole ring are small and stable cyclic ring structures in which the nitrogen atoms are capable of acting both as hydrogen bond donors and as acceptors at the receptor's active site in the biological system through different kinds of weak interactions, including hydrophobic effects, coordination bonds, ion-dipole, hydrogen bonds, pi-pi stacking, cation-pi, thus exerted a plethora of biological activities and extensively employed in the produc-tion of supramolecular drugs.…”
Section: Introductionmentioning
confidence: 99%