“…Nowadays, a lot of 1,2,4-triazole-based compounds have been extensively integrated into an array of therapeutic drugs and widely used in the clinic, namely; Triazolam (3), Alprazolam (4), Estazolam (5) (anticonvulsant and tranquilizer), [9] Itraconazole (6), Voriconazole (7), and Fluconazole (8) (antifungal), [10] Rizatriptan (9) (antimigraine agents) [11] Ribavirin (antiviral), [12] as well as Anastrozole (10) and Letrozole (11) (anticancer), [13] and so forth ( Figure 2). Numerous research articles focalized on synthesis and biological significance of 1, 2, 4-triazole derivatives as such as cytotoxic, [14] anticancer, [15] Antimycotic, [16] antimicrobial, [17] anti-inflammatory, [18] antihistamine, [19] antibacterial, [20] antihypertensive, [21] antimalarial, [22] analgesic, [23] and carbonic anhydrase inhibitors. [24] Food and Drug Administration (FDA) approved over 31 drug products containing 1,2,4-triazole scaffolds and more than 50 experimental drugs based on 1,2,4-triazole scaffolds.…”