A retrospective evaluation of the epithelial changes/lesions and neoplasms of the gallbladder in turkey and a review of the existing sampling methods: a multicentre study

Esendağlı, Güldal; Fg, Akarca; Balcı, Serdar; Argon, Asuman; Sş, Erhan; Turhan, Nesrin; Ni, Zengin; Sh, Keser; Çelik, Betül; Bulut, Türker; Abdullazade, Samir; Erden, Esra; Savaş, Berna; Bostan, T; Sağol, Özgül; Aa, Ağalar; Kepil, Nuray; Karslioğlu, Yıldırım; Günal, Armağan; Markoç, Fatma; Saka, Burcu; Özgün, Gonca; Şo, Özdamar; Bahadir, Burak; Kaymaz, Esin; Işık, Emine Göknur; Ayhan, Semin; Tunçel, Deniz; Bö, Yılmaz; Celi̇k, Serkan; Karabacak, Tuba; Ie, Seven; Ça, Çelikel; Güçin, Zühal; Ekinci, Özgür; Akyol, Gülen

doi:10.5146/tjpath.2017.01404

Cited by 8 publications

(8 citation statements)

References 9 publications

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“…Pyloric metaplasia in GI mucosal repair 135 intraepithelial neoplasia (PanIN) lesions in the pancreas. Pyloric metaplasia and intestinal metaplasia have also been noted in association with chronic cholecystitis and implicated in metaplasia to neoplasia progression similar to that in gastric carcinogenesis [49][50][51]. Gastric and intestinal metaplasia lineages are pathognomonic of Barrett's epithelium and the organization of the metaplastic glands resembles the structure of pyloric glands [52].…”

Section: Identification Of Pyloric Metaplasia In Other Glandular Mucomentioning

confidence: 99%

Pyloric metaplasia, pseudopyloric metaplasia, ulcer‐associated cell lineage and spasmolytic polypeptide‐expressing metaplasia: reparative lineages in the gastrointestinal mucosa

Goldenring

2018

The Journal of Pathology

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Summary The gastrointestinal mucosae provide a critical barrier between the external and internal milieu. Thus, damage to the mucosa requires an immediate response to provide appropriate wound closure and healing. Metaplastic lineages with phenotypes similar to the mucous glands of the distal stomach or Brunner’s glands have been associated with various injurious scenarios in the stomach, small bowel and colon. These lineages have been assigned various names including pyloric metaplasia, pseudopyloric metaplasia, Ulcer-associated cell lineage (UACL) and spasmolytic polypeptide-expressing metaplasia (SPEM). A re-examination of the literature on these various forms of mucous cell metaplasia suggests that pyloric type mucosal gland lineages may provide a ubiquitous response to mucosal injury throughout the gastrointestinal tract as well as in the pancreas, esophagus and other mucosal surfaces. While the cellular origin of these putative reparative lineages likely varies in different regions of the gut, their final phenotypes may converge on a pyloric type gland dedicated to mucous secretion. In addition to their healing properties in the setting of acute injury, these pyloric type lineages may also represent precursors to neoplastic transitions in the face of chronic inflammatory influences. Further investigations are needed to determine how discrete molecular profiles relate to the origin and function of pyloric-type metaplasias previously described by histological characteristics in multiple epithelial mucosal systems in the setting of acute and chronic damage.

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Section: Identification Of Pyloric Metaplasia In Other Glandular Mucomentioning

confidence: 99%

Pyloric metaplasia, pseudopyloric metaplasia, ulcer‐associated cell lineage and spasmolytic polypeptide‐expressing metaplasia: reparative lineages in the gastrointestinal mucosa

Goldenring

2018

The Journal of Pathology

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“…Antral metaplasia, hyperplasia, non-neoplastic polyps represent non-neoplastic lesions and can be found in around 9-59.5% of cases after cholecystectomy. 15,16 The bile-type epithelium with columnar cells and round to oval uniform nuclei differ from the dysplastic changes that are characterized by the loss of epithelium architecture, increased height of cells and nuclear crowding with presence of mitotic figures (Figure 3). While reactive changes blend gradually with the normal cells' architecture, real dysplasia has sharp demarcated areas adjacent to the normal biliary epithelium.…”

Section: Discussionmentioning

confidence: 99%

Cystic duct dysplasia after cholecystectomy: a systematic review of the literature

Mongelli¹,

Cianfarani²,

Giuseppe³

et al. 2019

Int Surg J

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In this article, we discuss the matter and suggest a possible management algorithm. METHODS Search strategyTwo researchers independently searched the PubMed, Cochrane Library and Google Scholar databases by combining "cholecystectomy" and "dysplasia" and ABSTRACT Approximately 1 to 3.5% of cholecystectomies are found to have incidental dysplasia on histological examination. Cases of positive resection margins on the cystic stump are rare and evidence lack. The aim of this article was to systematically review the literature and to suggest a possible management algorithm. We searched PubMed, Cochrane Library and Google Scholar databases by combining "cholecystectomy" and "dysplasia" and "cystic" according to preferred reporting items for systematic reviews and meta-analyses guidelines. Studies providing information about cystic duct dysplasia with positive resection margin after cholecystectomy were included. We identified 113 articles, of which three were considered eligible. Five patients had a high-grade dysplasia, one patient had a carcinoma and one had a low-grade dysplasia. Median follow-up was of 10.5 months (range: 0.5-26.6 months), no evidence of recurrence was found in patients with dysplasia, while the patient with diagnosis of cholangiocarcinoma died during follow-up. Patients with positive resection margins for dysplasia after cholecystectomy should be considered for a surgical treatment according to clinical and pathological factors. Simple cystic duct stump excision was suggested and seems to be safe and effective with no evidence of recurrence during follow-up when a R0 resection is achieved. A multidisciplinary approach and a surveillance program should be always taken into account.

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“…We used a form for patient consent. In the first macroscopic examination of the material in accordance with the decided method, the surgical margin of the ductus cysticus was sampled in a way that the sectional side could be seen completely and was sampled completely by removing a full slice from the fundus to the ductus cysticus ( Figure 1) (9). All polyps, if present, in the material (including cholesterol polyps) were sampled.…”

Section: Methodsmentioning

confidence: 99%

“…A Multicenter Prospective Study (4)(5)(6)(7)(8) and all these methods are important in detecting incidental gallbladder cancer. The Hepato-Pancreato-Biliary (HPB) Pathology Study Group has also conducted a multicenter retrospective study to assess gallbladder lesions and establish common macroscopy and microscopy protocols in our country (9).…”

Section: The Contribution Of Additional Sampling In Cholecystectomy Mmentioning

confidence: 99%

The contribution of additional sampling in cholecystectomy materials: a multicenter prospective study

Abdullazade¹,

Akarca²,

Esendağlı³

et al. 2020

TJPATH

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Objective: Cholecystectomy materials are frequently encountered in routine practice. The aim of this study was to determine the true frequency of gallbladder lesions, the diagnostic consistency, and standardization of reports after macroscopic sampling and microscopic evaluation based on previously defined criteria. Material and Method: 14 institutions participated in the study within the Hepato-Pancreato-Biliary Pathology Study Group. Routinely examined cholecystectomies within the last year were included in the study in these institutions. Additional sampling was performed according to the indications and criteria. The number of blocks and samples taken in the first macroscopic examination and the number of blocks and samples taken in the additional sampling were determined and the rate of diagnostic contribution of the additional examination was determined. Results: A total of 5,244 cholecystectomy materials from 14 institutions were included in the study. Additional sampling was found to be necessary in 576 cases (10.98%) from all institutions. In the first macroscopic sampling, the mean of the numbers of samples was approximately 4 and the number of blocks was 2. The mean of the numbers of additional samples and blocks was approximately 8 and 4, respectively. The diagnosis was changed in 144 of the 576 new sampled cases while the remaining 432 stayed unaltered. Conclusion: In this study, it was observed that new sampling after the first microscopic examination of cholecystectomy materials contributed to the diagnosis. It was also shown that the necessity of having standard criteria for macroscopic and microscopic examination plays an important role in making the correct diagnosis.

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A retrospective evaluation of the epithelial changes/lesions and neoplasms of the gallbladder in turkey and a review of the existing sampling methods: a multicentre study

Cited by 8 publications

References 9 publications

Pyloric metaplasia, pseudopyloric metaplasia, ulcer‐associated cell lineage and spasmolytic polypeptide‐expressing metaplasia: reparative lineages in the gastrointestinal mucosa

Pyloric metaplasia, pseudopyloric metaplasia, ulcer‐associated cell lineage and spasmolytic polypeptide‐expressing metaplasia: reparative lineages in the gastrointestinal mucosa

Cystic duct dysplasia after cholecystectomy: a systematic review of the literature

The contribution of additional sampling in cholecystectomy materials: a multicenter prospective study

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