Microcefalia no Brasil: prevalência e caracterização dos casos a partir do Sistema de Informações sobre Nascidos Vivos (Sinasc), 2000-2015

Marinho, Fátima; Araújo, Valdelaine Etelvina Miranda de; Porto, Denise Lopes; Ferreira, Helena; Coelho, Marta Roberta Santana; Lecca, Roberto Carlos Reyes; Oliveira, Hélio de; Poncioni, Ivana; Maranhão, Maria Helian Nunes; Mendes, Yluska Myrna Meneses Brandão e; Fernandes, Roberto Men; Lima, Raquel Barbosa de; Neto, Dácio de Lyra Rabello

doi:10.5123/s1679-49742016000400004

Cited by 94 publications

(100 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the period prior to the introduction of this infectious agent (Kindhauser et al, 2016), Brazil registered an average of 164 new cases of microcephaly per year (Marinho et al, 2016), and a prevalence of 5.4/ 10,000 live births (Orioli et al, 2017). Thus, considering that there was space-time correlation of this epidemic with Zika epidemic, the hypothesis that the increase in frequency of these cases could be related to ZIKV congenital infection was immediately raised.…”

Section: Introductionmentioning

confidence: 99%

“…Since the appearance of the first cases of microcephaly/CZS, up until January 4, 2018, 720 CZS cases in 26 countries of the Americas (Anon., 2017) had been confirmed by the Pan American Health Organization (PAHO) and the World Health Organization (WHO) (Marinho et al, 2016) In Brazil, from November 2015 to July 2018, the Ministry of Health (Ministério da Saúde -MS) confirmed 3,226 cases of microcephaly and/or neurological changes related to ZIKV in fetuses and children.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Congenital Zika Syndrome: Prevalence of low birth weight and associated factors. Bahia, 2015–2017

Carvalho-Sauer

Costa

Barreto

et al. 2019

International Journal of Infectious Diseases

View full text Add to dashboard Cite

Objective: The clinical manifestations of Congenital Zika Syndrome (CZS) are not fully known, for example its effect on birth weight. This study estimated the prevalence of low birth weight (LBW) among children with CZS, and identified associated factors. Methods: Cross-sectional study involving 393 children with CZS living in Bahia, Brazil, in 2015-2017. Official Information Systems were the data sources. We calculated LBW prevalence and applied Logistic Regression to assess associated factors. Results: Prevalence of LBW among children with CZS was 37.2%. Excluding pre-term births the proportion was 29.9%. This prevalence was 81.0% and 28.0% among children born pre-term and term/post term, respectively. There was a higher proportion (53.2%) in female children, and in those delivered by cesarean section (51.4%). Most mothers were single/separated (62.1%) and had a low level of schooling (70.0%). In the model adjusted for type of delivery, preterm births presented a 10.8 times greater chance of presenting LBW than term/post-term ones. However, the Confidence Interval was very wide. Adjusting for gestation duration, children born by cesarean section had a 1.63 higher probability of presenting LBW than those born by vaginal delivery (OR = 1,63; CI 95% 1.01, 2.63). Conclusions: The prevalence of LBW among children with CZS was very elevated, both preterm and term/ post-term live births. This can contribute to increasing their risk for morbimortality. The association of LBW with prematurity and cesarean deliveries is known, but in children with CZS, it has not been clarified whether or not this is related to pathological conditions caused by fetal infection by the Zika virus.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Congenital Zika Syndrome: Prevalence of low birth weight and associated factors. Bahia, 2015–2017

Carvalho-Sauer

Costa

Barreto

et al. 2019

International Journal of Infectious Diseases

View full text Add to dashboard Cite

show abstract

“…In addition, the same vector also transmits the yellow fever virus. Still in 2015, there was an unexpected increase in microcephaly cases associated with intrauterine exposure to Zika virus [34][35][36][37] . In February 2016, this severe epidemiological situation, after occurrence of a similar situation in French Polynesia, in 2014, was declared a public health emergency of international concern (PHEIC) due to possible associations to Zika virus 38 .…”

Section: Discussionmentioning

confidence: 99%

Aumento da carga de dengue no Brasil e unidades federadas, 2000 e 2015: análise do Global Burden of Disease Study 2015

Araújo

Bezerra

Amâncio

et al. 2017

Rev. bras. epidemiol.

Self Cite

View full text Add to dashboard Cite

ABSTRACT:Objective: To describe the main metrics on dengue generated by Global Burden of Disease (GBD) Study 2015, for Brazil and its 27 federated units, in the years 2000 and 2015. Methods: The metrics described were: incidence and mortality rates by dengue, standardized by age, years of life lost (YLL), years lived with disability (YLD), and disability-adjusted life years (DALY) (in absolute frequency and age-standardized rates). The estimated metrics were presented with uncertainty intervals (UI 95%) for the years 2000 and 2015, accompanied by the relative percentages of changes. Results: The number of cases increased 232.7% and the number of deaths increased 639.0% between 2000 and 2015 in the country. The incidence rate varied 184.3% and the mortality rate was low, but with an increase of 500.0% in the period evaluated. The YLL, YLD, and DALY rates increased 420.0, 187.2, and 266.1%, respectively. In 2015, DALY was similar among women and men (21.9/100,000). The DALY increased more than double in all the Brazilian federated units. Conclusion:The marked increase in dengue over the years is associated with the introduction and/or circulation of one or more serotypes of the transmitter virus and an increasing proportion of patients affected by the severe form of the disease. Despite the low mortality rate of the disease in comparison between the years of study, the disease contributes to the loss of healthy years of life in Brazil as it affects a large number of people, from all age groups, causing some degree of disability during the infection and deaths, especially, in children.

show abstract

“…O DNPM atípico nem sempre está ligado à presença de alterações neurológicas ou estruturais e crianças com desenvolvimento motor atípico merecem atenção e ações específicas, uma vez que problemas de coordenação e controle do movimento podem durar até a fase adulta, trazendo atrasos motores frequentemente associados a prejuízos secundários de ordem psicológica e social que dificultam a socialização de crianças e o seu desempenho escolar 6 . Apesar de observa na prática clínica o importante atraso do DNPM das crianças acometidas pelo ZIKAV, não há registro na literatura sobre o grau de comprometimento do seu desenvolvimento e devido ao surto de contaminação pelo ZIKAV e associação deste com o crescente número de recém-nascidos portadores de microcefalia, além de outras alterações do SNC, que poderão impactar no desenvolvimento neuropsicomotor e consequentemente na inserção social destas crianças, associado a ausência de dados sobre o DNPM nessa população.…”

Section: O Vírusunclassified

Desenvolvimento Neuropsicomotor Em Crianças Com Microcefalia Associado Ao Zika Vírus

2017

View full text Add to dashboard Cite

| Introduction:The Zika Virus (ZIKAV) in Brazil was identified in early 2015, concomitantly with an increase in cases of microcephaly, with 1,248 new cases, representing a jump of twenty times in relation to the last years. Objective: To evaluate neuropsychomotor development (NPMD) in patients with microcephaly by ZIKAV. Methods: Cross-sectional, observational research with descriptive analysis, through the review of data in medical records with the sample composed of 22 newborns with microcephaly associated with ZIKAV. Results: The mean age at the consultation was 8.9 months (SD ± 2.13), gestational age 38.13 (SD ± 2.38) at birth, weight 2603.9 grams (SD ± 579.5) and cephalic perimeter of 28.8 (SD ± 1.74) centimeters. 10 (45.45%) patients presented a history of seizures, 11 (50%) visual alterations, 2 (9.09%) auditory and 4 (18.18%) articular. NPMD delays were observed. Upper and lower limb tonus was increased, and upper limbs presented mean upper limb value, but without statistical significance (p = 0.1). Conclusion: ZIKAV-associated microcephalic patients present delayed neuropsychomotor development, visual, auditory and sensory alterations, impacting the functional independence and quality of life of these patients.

show abstract

Microcefalia no Brasil: prevalência e caracterização dos casos a partir do Sistema de Informações sobre Nascidos Vivos (Sinasc), 2000-2015

Abstract: the high number of microcephaly cases in 2015 reinforces the importance of Sinasc and the need to improve the surveillance of congenital anomalies.

Cited by 94 publications

References 8 publications

Congenital Zika Syndrome: Prevalence of low birth weight and associated factors. Bahia, 2015–2017

Congenital Zika Syndrome: Prevalence of low birth weight and associated factors. Bahia, 2015–2017

Aumento da carga de dengue no Brasil e unidades federadas, 2000 e 2015: análise do Global Burden of Disease Study 2015

Desenvolvimento Neuropsicomotor Em Crianças Com Microcefalia Associado Ao Zika Vírus

Contact Info

Product

Resources

About