Anti-amyloid agents for treating incipient Alzheimer's disease: a new hope?

Why do anti-amyloid beta antibodies not work? Time to reconceptualize dementia pathophysiology by incorporating astrocyte melatonergic pathway desynchronization from amyloid-beta production

“…Within this framework, it could be predicted that anti-amyloid antibody therapy would afford little protection against dementia, which the data broadly support. 1 …”

“…A recent editorial in the Brazilian Journal of Psychiatry highlighted the hopes, problems, and disappointments of anti-amyloid antibody treatments in the management of Alzheimer’s disease. 1 The amyloid cascade hypothesis of Alzheimer’s disease has predominated for 4 decades, coupled to hyperphosphorylated tau to form amyloid-β plaques and tangles, respectively. This has provided no significant benefits to the management of Alzheimer’s disease pathophysiology.…”