A systematic review of observational, naturalistic, and neurophysiological outcome measures of nonpharmacological interventions for autism

Godoy, Patricia; Sumiya, Fernando Mitsuo; Seda, Leonardo; Shephard, Elizabeth

doi:10.47626/1516-4446-2021-2222

Cited by 4 publications

(4 citation statements)

References 151 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We continue to perform systematic video recordings as well as clinical assessments of newly treated children. The ABCS fulfills some essential requirements of a “naturalistic method of assessment” (Godoy et al, 2022) and has great face validity. In view of the overall encouraging findings with the method our group is now looking into the possibility of applying artificial intelligence (AI) techniques, that is, ways of “teaching a machine” the rules of ABCS scoring.…”

Section: Discussionmentioning

confidence: 99%

“…Another limitation of most existing measures is that they show sensitivity to change only for longer‐term interventions, that is, therapeutic efforts lasting 1 year or longer. Regarding the suitability of the ADOS‐2 (Autism Diagnostic Observation Schedule, Lord et al, 2012; German version: Poustka et al, 2015) as an outcome measure in early intervention studies, several aspects need to be considered: on the one hand, the ADOS Calibrated Severity Scores (CSS) provide standardization and allow comparison across different ADOS modules and thus between children with different levels of ASD severity; on the other hand, the ADOS was developed for diagnostic purposes and there are doubts whether it is sufficiently sensitive to capture small, but relevant behavioral changes (Godoy et al, 2022; McConachie et al, 2015). Efforts have been made to increase the sensitivity of the ADOS for small changes in social communication.…”

Section: Introductionmentioning

confidence: 99%

“…Improvement in social communication, one of the core symptom areas in ASD, may occur subtly, and is thus difficult to capture by global measures of intervention responses. Anagnostou et al (2015) and Godoy et al (2022) evaluated existing social communication measures and listed key classification criteria such as clinical relevance and psychometric properties (validity, reliability, and sensitivity to change). Sensitivity to change and clinical validity are considered crucial criteria given that only few interventions have so far shown to alter core autism symptoms.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Clinical utility of the standardized observation tool Autism Behavior Coding System for early intervention research in autism spectrum disorder

Spiegel,

Notter,

Lazari

et al. 2023

Autism Research

View full text Add to dashboard Cite

The Autism Behavior Coding System (ABCS) was developed to help evaluating the effectiveness of early intensive interventions in children with autism spectrum disorder (ASD). The video‐based ABCS assesses eight core autistic behavioral variables during therapist‐child interaction using standardized quantitative criteria, four behaviors according to their frequency of occurrence, four according to their duration. The present study focuses (1) on the correspondence of ABCS scores with scores on two standard clinical instruments (the ADOS‐2 and an ASD‐adaptation of the Children's Global Assessment Scale, DD‐CGAS), (2) on the sensitivity to change of ABCS scores by the end of an intensive 18 days intervention period (EIP) and (c) on the predictability of short‐ and longer‐term changes in social and repetitive behaviors from ABCS scores at baseline and EIP. Data from 51 children (42 M, 9 F; median age 45 months) followed over 1 year were available. There were significant correlations at baseline between several ABCS scores and ADOS‐2 as well as DD‐CGAS scores. Correlations at EIP between some ABCS and DD‐CGAS scores were highly significant. Four ABCS scores reflected significant changes from baseline to EIP. Several baseline ABCS scores were predictive of DD‐CGAS and ADOS‐2 scores at EIP and Year 1. However, associations between ABCS score changes from baseline to EIP and the clinical scale changes by Year 1 were not significant. It is concluded that several ABCS scores have adequate clinical validity and sensitivity to change. The short‐term changes in ABCS scores and their relationship to longer‐term clinical changes need further study.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical utility of the standardized observation tool Autism Behavior Coding System for early intervention research in autism spectrum disorder

Spiegel,

Notter,

Lazari

et al. 2023

Autism Research

View full text Add to dashboard Cite

show abstract

“…Neurodevelopmental disorders are highly heterogeneous in terms of their epidemiology 21 , clinical characteristics, causes 22 , burden, treatment responses and tolerability 23,24 , and outcomes 25 . Notably, ODD and CD are often comorbid with neurodevelop mental disorders, in particular ADHD 26 .…”

mentioning

confidence: 99%

Candidate diagnostic biomarkers for neurodevelopmental disorders in children and adolescents: a systematic review

et al. 2023

View full text Add to dashboard Cite

Neurodevelopmental disorders – including attention‐deficit/hyperactivity disorder (ADHD), autism spectrum disorder, communication disorders, intellectual disability, motor disorders, specific learning disorders, and tic disorders – manifest themselves early in development. Valid, reliable and broadly usable biomarkers supporting a timely diagnosis of these disorders would be highly relevant from a clinical and public health standpoint. We conducted the first systematic review of studies on candidate diagnostic biomarkers for these disorders in children and adolescents. We searched Medline and Embase + Embase Classic with terms relating to biomarkers until April 6, 2022, and conducted additional targeted searches for genome‐wide association studies (GWAS) and neuroimaging or neurophysiological studies carried out by international consortia. We considered a candidate biomarker as promising if it was reported in at least two independent studies providing evidence of sensitivity and specificity of at least 80%. After screening 10,625 references, we retained 780 studies (374 biochemical, 203 neuroimaging, 133 neurophysiological and 65 neuropsychological studies, and five GWAS), including a total of approximately 120,000 cases and 176,000 controls. While the majority of the studies focused simply on associations, we could not find any biomarker for which there was evidence – from two or more studies from independent research groups, with results going into the same direction – of specificity and sensitivity of at least 80%. Other important metrics to assess the validity of a candidate biomarker, such as positive predictive value and negative predictive value, were infrequently reported. Limitations of the currently available studies include mostly small sample size, heterogeneous approaches and candidate biomarker targets, undue focus on single instead of joint biomarker signatures, and incomplete accounting for potential confounding factors. Future multivariable and multi‐level approaches may be best suited to find valid candidate biomarkers, which will then need to be validated in external, independent samples and then, importantly, tested in terms of feasibility and cost‐effectiveness, before they can be implemented in daily clinical practice.

show abstract

Developmental, Behavioural and NDBI Interventions in Autistic Children or at Elevated Likelihood of Autism: A Systematic Review of Neural Outcomes

Zanatta,

Siew,

van der Paelt

et al. 2024

Rev J Autism Dev Disord

View full text Add to dashboard Cite

A systematic review of observational, naturalistic, and neurophysiological outcome measures of nonpharmacological interventions for autism

Cited by 4 publications

References 151 publications

Clinical utility of the standardized observation tool Autism Behavior Coding System for early intervention research in autism spectrum disorder

Clinical utility of the standardized observation tool Autism Behavior Coding System for early intervention research in autism spectrum disorder

Candidate diagnostic biomarkers for neurodevelopmental disorders in children and adolescents: a systematic review

Developmental, Behavioural and NDBI Interventions in Autistic Children or at Elevated Likelihood of Autism: A Systematic Review of Neural Outcomes

Contact Info

Product

Resources

About