Atividade anti-helmíntica dos extratos aquoso e etanólico do fruto da Morinda citrifolia sobre Ascaridia galli

Abstract

A atividade anti-helmíntica dos extratos aquoso e etanólico do fruto da Morinda citrifolia (noni) foi avaliada em aves poedeiras naturalmente infectadas por Ascaridia galli. A atividade anti-helmíntica in vitro foi determinada em parasitos adultos. O extrato aquoso e etanólico foram testados nas seguintes concentrações: 1,69; 3,37; 6,74; 13,48 AbstractThe anthelmintic activity of aqueous and ethanolic extracts of Morinda citrifolia fruit (noni) was evaluated in chicken naturally infected by Ascaridia galli. The anthelmintic activity in vitro was determined in adult parasites. The aqueous and ethanolic extracts were used in the following concentrations: 1.69; 3.37; 6.74; 13.48 e 26.96 mg.mL -1 and 4.17; 8.34; 16.68; 33.36 and 66.72 mg.mL -1 , respectively. The anthelmintic activity in vivo was determined by the administration of 10 mL.kg -1 of the aqueous (50.1 mg.mL -1 ) and ethanolic (24.6 mg.mL -1 ) extracts during three consecutive days. Later the chickens were euthanized and necropsy was performed in order to count the remaining helminths. The data were analyzed by the Student-Newman-Keuls test. In the concentrations of 13.48 and 26.96 mg.mL -1 , the aqueous extract demonstrated mortality of 46.67 and 50%, respectively, there was a significative difference from the negative control (P < 0.05). The ethanolic extract presented statistical difference from the negative control (diluent) (P < 0.05) for the concentrations of 33.36 and 66.72 mg.mL -1 , expressed by a mortality rate of 66.67 and 76.67%, respectively. In the in vivo test, the aqueous extract of noni fruit showed 27.08% of elimination, deferring statistically from the control group. There was no statistical difference between the ethanolic extract treatments and the control (P > 0.05). It follows that the anthelmintic activity of noni fruit test showed satisfactory results in vitro, there is a need for studies in higher concentrations in the in vivo test.

Larvicidal potential of Mikania glomerata SPRENGEL extract on Ancylostoma caninum larvae

“…During the seven days of interaction statistical difference between treatment groups was noted, not being demonstrated only between T25 and T50 mg/ml, suggesting that these concentrations the larvicidal effect demonstrated action stability. This feature is also observed in other studies on anthelmintic activity (Lone et al, 2012;Dias de Castro et al, 2013;Brito et al, 2009;Santana et al, 2013).…”

“…However, in hours 72 and 96 at concentrations of 13.48 and 26.96 mg.ml -1 , there was a difference, considering the aqueous extract of M. citrifolia, the positive control and the negative control (water). Comparing the mortality rates of the treatment and the negative control, it is observed that in the last two periods of time, there is a greater discrepancy of the effectiveness of the M. citrifolia aqueous extract in relation to the test with water (Brito et al, 2009).…”

Morphoanatomic characterization of the stem and the leaf of Tabernaemontana catharinensis A.DC (Apocynaceae) and antimutagenic activity of its leaves

“…Several plants have been used as folk medicine for the treatment of several diseases (Melo-Reis et al, 2011), some of which, such as Solanum validinervium (Suarez et al, 2006), Morinda citrifolia (Brito et al, 2009) and Annona squamosa (Nandhakumar & Indumathi, 2012), showed highly interesting characteristics, while others, such as Bauhinia monandra (Macêdo et al, 2008), Alchornea grandulosa, A. castaneaefolia (Santos et al, 2010) and Cochlospermum regium (Castro et al, 2004;Andrade et al, 2008), proved to be genotoxic.…”

The impact of convective drying on the color, phenolic content and antioxidant capacity of noni (Morinda citrifolia L.)

“…Although the use of noni for human consumption has become very controversial in recent years, since on the one hand several authors (Kadiri et al, 1999;Collins, 2009;Serafini et al, 2011;Alencar et al, 2013) have conducted experiments in vivo use of this fruit and have reported a nephrotoxic and genotoxic effect, other authors have evaluated the pharmacological activity of M. citrifolia by in vivo and clinical trials and found among other anti cancer effect (Kamiya et al, 2010) agent hepatoprotective (Lin et al, 2013), anti dyslipidemia (Mandukhail et al, 2010), immune stimulator (Krishnaiah et al, 2012), anthelminthic activity (Brito et al, 2009) and anti inflammatory (Fletcher et al, (2013). Given these contradictory highlighted in some countries have banned its use, while the vast majority is still used for the treatment of various diseases.…”