A pancreatic mixed neuroendocrine-non-neuroendocrine neoplasms (MiNEN) (NET and undifferentiated carcinoma of the pancreas with osteoclast-like giant cells) with metastatic neuroendocrine component to the liver

Gao, Guofeng; Qorbani, Amir; Zhou, Carol L. Ecale

doi:10.4322/acr.2020.201

Autops Case Rep

2021

DOI: 10.4322/acr.2020.201

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A pancreatic mixed neuroendocrine-non-neuroendocrine neoplasms (MiNEN) (NET and undifferentiated carcinoma of the pancreas with osteoclast-like giant cells) with metastatic neuroendocrine component to the liver

Guofeng Gao¹,

Amir Qorbani²,

Carol L. Ecale Zhou³

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Cited by 3 publications

(1 citation statement)

References 18 publications

(22 reference statements)

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“…Immunohistochemistry is mandatory to test the nature of the neuroendocrine component, which is also recommended to evaluate the subtype of the nonneuroendocrine (11)(12)(13)15,16,19,20,22,23,25). Preoperative diagnosis was rarely established, and only a few cases reported had been diagnosed through preoperative biopsy with endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) specimens (17)(18)(19)21,24). Recently, EUS-FNA, a minimally invasive technique for histological diagnoses, has been widely used to diagnose pancreatic tumors, and several reports have used it for preoperative diagnosis in pancreatic MiNEN.…”

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Mixed neuroendocrine nonneuroendocrine neoplasms of the pancreas: a case report and literature review of pancreatic mixed neuroendocrine nonneuroendocrine neoplasm

Wang¹,

Lou²,

Qin³

et al. 2021

Gland Surg

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A 36-year-old woman underwent left lateral hepatic lobectomy and tumor enucleation of the pancreatic head due to the diagnosis of mixed neuroendocrine nonneuroendocrine neoplasms (MiNENs).Her past medical history revealed an ill-defined mass in the pancreatic uncinate (approximately 1 cm in size) and liver nodules in segment II, suggesting a pancreatic neuroendocrine tumor (pNET) and liver metastases.After the operation, pathological examination showed that the lesion in the pancreas was MiNEN. The neuroendocrine component consisted of grade 1 (G1) NETs, and the nonneuroendocrine part was welldifferentiated adenocarcinoma. Additionally, in hepatic lesions, the type of pancreaticobiliary duct in moderately differentiated adenocarcinoma indicated the source of tumor cells. We present the following case in accordance with the CARE reporting checklist. MiNENs of the pancreas are extremely rare and heterogeneous malignancies. Owing to the rarity of pancreatic MiNEN, no structured guidelines on preoperative diagnostics, therapy and follow-up exist thus far. Thus, problems in differential diagnosis and appropriate therapy may arise when treating suspected MiNEN patients. We performed a rigorous search on pancreatic MiNEN via PubMed and Web of Science. In total, 167 studies were identified, and 28 cases in 15 studies about pancreatic MiNEN were assessed. All the available information was listed and fully discussed.

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confidence: 99%

Mixed neuroendocrine nonneuroendocrine neoplasms of the pancreas: a case report and literature review of pancreatic mixed neuroendocrine nonneuroendocrine neoplasm

Wang¹,

Lou²,

Qin³

et al. 2021

Gland Surg

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Undifferentiated Pancreatic Carcinoma with Osteoclast-like Giant Cells: A Case Report

Jeon,

So,

Koo

et al. 2023

Korean J Pancreas Biliary Tract

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EUS-guided fine needle biopsy is able to provide diagnosis in rare osteoclast-like giant cells undifferentiated carcinoma of the pancreas: report of two cases

Pop

Diaconu

Rimbaș

et al. 2023

Romanian Journal of Internal Medicine

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Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells (UC-OGC) is a rare subtype of pancreatic cancer, accounting for less than 1% of all pancreatic tumors. Preoperative diagnosis is cumbersome as cross-sectional imaging is often not capable to distinguish between UCOGC and other pancreatic tumors such as pancreatic adenocarcinoma, mucinous carcinoma or neuroendocrine tumors and specific tumor markers seem to be lacking. Endoscopic ultrasound r `m(EUS) with tissue acquisition via fine-needle aspiration (FNA) or biopsy (FNB) with microscopic HE staining and immunohistochemistry allows for an accurate diagnosis, thus influencing further treatment. We present herein the cases of two patients with osteoclast-like giant cells tumors of the pancreas diagnosed by EUS-guided fine needle biopsy and perform a literature review on the role of EUS-guided biopsy for diagnosis.

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A pancreatic mixed neuroendocrine-non-neuroendocrine neoplasms (MiNEN) (NET and undifferentiated carcinoma of the pancreas with osteoclast-like giant cells) with metastatic neuroendocrine component to the liver

Cited by 3 publications

References 18 publications

Mixed neuroendocrine nonneuroendocrine neoplasms of the pancreas: a case report and literature review of pancreatic mixed neuroendocrine nonneuroendocrine neoplasm

Mixed neuroendocrine nonneuroendocrine neoplasms of the pancreas: a case report and literature review of pancreatic mixed neuroendocrine nonneuroendocrine neoplasm

Undifferentiated Pancreatic Carcinoma with Osteoclast-like Giant Cells: A Case Report

EUS-guided fine needle biopsy is able to provide diagnosis in rare osteoclast-like giant cells undifferentiated carcinoma of the pancreas: report of two cases

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