Nanotechnology and MRI contrast enhancement

Matson, Michael L.; Wilson, Lon J.

doi:10.4155/fmc.10.3

Cited by 71 publications

(19 citation statements)

References 82 publications

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“…Over the past decade, interest in the development of nanoparticles for clinical applications, such as diagnosis and drug delivery, has increased exponentially, along with the number of specific nanoparticle formulations reported in the literature [1–5]. Given the variety of nanomaterials from which they can be constructed, the array of physicochemical properties they can possess, and the assortment of specific molecular processes that can be targeted in vivo , the number of potential nanoparticle combinations is truly astronomical.…”

Section: Introductionmentioning

confidence: 99%

ICP-MS analysis of lanthanide-doped nanoparticles as a non-radiative, multiplex approach to quantify biodistribution and blood clearance

et al. 2012

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Recent advances in material science and chemistry have led to the development of nanoparticles with diverse physicochemical properties, e.g. size, charge, shape, and surface chemistry. Evaluating which physicochemical properties are best for imaging and therapeutic studies is challenging not only because of the multitude of samples to evaluate, but also because of the large experimental variability associated with in vivo studies (e.g. differences in tumor size, injected dose, subject weight, etc.). To address this issue, we have developed a lanthanide-doped nanoparticle system and analytical method that allows for the quantitative comparison of multiple nanoparticle compositions simultaneously. Specifically, superparamagnetic iron oxide (SPIO) with a range of different sizes and charges were synthesized, each with a unique lanthanide dopant. Following the simultaneous injection of the various SPIO compositions into tumor-bearing mice, inductively coupled plasma mass spectroscopy (ICP-MS) was used to quantitatively and orthogonally assess the concentration of each SPIO composition in serial blood samples and the resected tumor and organs. The method proved generalizable to other nanoparticle platforms, including dendrimers, liposomes, and polymersomes. This approach provides a simple, cost-effective, and non-radiative method to quantitatively compare tumor localization, biodistribution, and blood clearance of more than 10 nanoparticle compositions simultaneously, removing subject-to-subject variability.

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Section: Introductionmentioning

confidence: 99%

ICP-MS analysis of lanthanide-doped nanoparticles as a non-radiative, multiplex approach to quantify biodistribution and blood clearance

et al. 2012

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“…Still, the problem arising from the use of such heavy metal compounds, besides unspecific reactivity, is the lack of information about their metabolic destiny, possible accumulation, and toxicity after being released after CPC degradation. 16,17,30,31 In the current study, the concentration of both radiopacifiers was set at 5% wt/wt. The structural embedding of two nanoparticles types into the silica carrier beads prevents/inhibits their release as free metal ions, and allows even the encapsulation of much higher concentrations, while avoiding the above mentioned side effects.…”

Section: Dual Contrast Agent For Bone Imagingmentioning

confidence: 99%

“…Colloidal gold and iron oxide nanoparticles were selected as embedded agents for, respectively, CT and MR imaging, as both compounds are widely characterized and approved for clinical use. 16,17 After in vitro characterization, the developed contrast agent was tested in vivo, in a femoral condyle defect model in rats. Effects were monitored by scanning the same animals with both CT and MRI up to 8 weeks postsurgery.…”

Section: Introductionmentioning

confidence: 99%

Dual Contrast Agent for Computed Tomography and Magnetic Resonance Hard Tissue Imaging

Ventura

Sun²,

Rusu³

et al. 2013

Tissue Engineering Part C: Methods

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Calcium phosphate cements (CPCs) are commonly used bone substitute materials, which closely resemble the composition of the mineral phase of bone. However, this high similarity to natural bone also results in difficult discrimination from the bone tissue by common imaging modalities, that is, plain X-ray radiography and threedimensional computed tomography (CT). In addition, new imaging techniques introduced for bone tissue visualization, like magnetic resonance imaging (MRI), face a similar problem. Even at high MRI resolution, the lack of contrast between CPCs and surrounding bone is evident. Therefore, this study aimed to evaluate the feasibility of a dual contrast agent, traceable with both CT and MRI as enhancers of CPC/bone tissue contrast. Our formulation is based on the use of silica beads as vectors, which encapsulate and carry contrast-enhancing nanoparticles, in our case, colloidal Gold and Superparamagnetic Iron oxide particles (SPIO). The bead suspension was incorporated within a calcium phosphate powder. The resultant cements were then tested both in vitro and in vivo in a femoral condyle defect model in rats. Results showed that the mechanical properties of the cement were not significantly affected by the inclusion of the beads. Both in vitro and in vivo data proved the homogeneous incorporation of the contrast within the cement and its visual localization, characterized by a short-term CT contrast enhancement and a long-term MR effect recognizable by the characteristic blooming shape. Finally, no signs of adverse tissue reactions were noticed in vivo. In conclusion, this study proved the feasibility of a multimodal contrast agent as an inert and biocompatible enhancer of CaP cement versus bone tissue contrast.

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“…191,192 The rigid shape (sphere for C 60 However, there are two challenges that complicate the study of the biological activity of fullerenes. At first, fullerenes are almost entirely insoluble in water, which reduces the availability of biologically active molecules.…”

Section: Iii3 Biomedical Applicationsmentioning

confidence: 99%