Estudo Do L-Triptofano Na Depressão Ocorrida Pela Doença De  Alzheimer Em Modelos Experimentais

Miri, Andressa Leticia; Hosni, Andressa Panegalli; Gomes, Jossinelma Camargo; Kerppers, Ivo Ilvan; Pereira, Mário César da Silva

doi:10.4025/jphyseduc.v28i1.2839

Cited by 10 publications

(8 citation statements)

References 23 publications

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“…Still, when the analysis was performed by means of the effect size (Table 6), there were no significant positive responses in relation to the treatments (Table 3), but a significant improvement was observed with all treatments, especially the isolated nanoparticles, which showed an improvement in a greater number of variables in relation to the displacement within the arena. Corroborating with the study where used L-Tryptophan for 21 days and found improvement in the motor behavior of rats after treatment, which in our study had a beneficial effect even in a shorter period of time, without counting the potentiation through Nanoparticles 17 .…”

Section: Discussionsupporting

confidence: 85%

Efeito agudo do L-Triptofano e das Nanopartículas de L-Triptofano associadas ou não ao exercício físico no comportamento cognitivo e motor de modelo experimental de Alzheimer / Acute effect of L-Tryptophan and L-Tryptophan Nanoparticles associated or not with physical exercise on cognitive and motor behavior of Alzheimer's experimental model

Furmann¹,

IlvanKerppers²,

Carraro³

et al. 2021

BJDV

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Introdução: A DA apresenta gradativamente diversos sinais e sintomas que causam grande comorbidade e necessidade de cuidados e tratamentos alternativos. O L-triptofano, com ação relacionada à dinâmica cerebral, depressão e ansiedade é precursor da serotonina, importante neurotransmissor cerebral, que pode ter sua ação potencializada pelo uso das Nanopartículas. O exercício físico por sua vez, também pode estar relacionado à alteração de monoaminas cerebrais como a serotonina, sendo mais uma alternativa de tratamento. Portanto, este estudo tem como objetivo analisar a eficácia do L-Triptofano e das Nanopartículas de L-Triptofano associadas ao efeito agudo do exercício físico em modelo experimental de Alzheimer. Materiais e Métodos: A amostra foi composta por 20 ratos, divididos em 4 grupos (n=5) GLt (L-Triptofano), GN (Nanopartículas), GN+e (Nanopartículas+exercício) e GLt+e (L-Triptofano+exercício), foram realizados testes de ansiedade, memória espacial, memória aversiva, e comportamento motor. Resultados: De acordo com a análise estatística, houve melhora significativa em relação à ansiedade no GLt e no GN com maior força, já em relação ao comportamento motor apenas o GLt+e demonstrou efeitos positivos significativos como tratamento. Apenas por meio do Size Effect pode-se observar que o GLt apresentou diferença em relação ao comportamento motor, e o GN obteve diferença na memória aversiva e em diversas variáveis do comportamento motor, demonstrando melhor desempenho em relação ao GLt como método de tratamento. Porém, quando associado ao exercício físico o L-Triptofano apresentou mais valores com diferença entre as variáveis de comportamento motor do que quando associado às Nanopartículas. Todavia apenas na associação do exercício agudo às Nanopartículas houve melhora da ansiedade. Discussão: Outros tratamentos com fármacos também utilizados são as BZD, indicadas para situações agudas, por curtos períodos de tempo, porém ainda não apresenta eficácia satisfatória, assim como ainda não há um consenso em relação aos benefícios do exercício para a população portadora de DA, pois existem controvérsias em relação ao melhor tipo de exercício, intensidade e duração necessários para produzirem a redução dos sintomas depressivos. Sendo assim o L-Triptofano e as Nanopartículas surgem como uma alternativa de tratamento, necessitando de novos estudos com diferentes avaliações e duração de tratamento. Conclusão: Nanopartículas de L-Triptofano apresentam um grande potencial para ser utilizado como método de tratamento da DA, uma vez que diminuiu o sintoma de ansiedade e melhorou o comportamento motor dos animais.

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Section: Discussionsupporting

confidence: 85%

Efeito agudo do L-Triptofano e das Nanopartículas de L-Triptofano associadas ou não ao exercício físico no comportamento cognitivo e motor de modelo experimental de Alzheimer / Acute effect of L-Tryptophan and L-Tryptophan Nanoparticles associated or not with physical exercise on cognitive and motor behavior of Alzheimer's experimental model

Furmann¹,

IlvanKerppers²,

Carraro³

et al. 2021

BJDV

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“…None of the treatments performed in this study demonstrated efficacy in altering this, a result justifiable by the short time period of the treatment, or the influence of external environmental factors such as temperature, noise, or the luminosity of the environment [17]. In a study in 2017, after treatment with L-Tryptophan for 21 days, there was significant improvement in the spatial memory of their rats, differing from the present study, probably due to the longer treatment time compared to the six days that were used in this study [18].…”

Section: Discussioncontrasting

confidence: 61%

Comparative Study of the Efficacy of L-Tryptophan Nanoparticles on Motor and Cognitive Behavior in an Alzheimer's Experimental Model

Furmann¹,

Miri

Hosni³

et al. 2021

Braz. arch. biol. technol.

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Alzheimer's disease is the most common neurodegenerative disorder, with cognitive as well as behavioral manifestations. Also related to this pathology, is the decreased production and activation of some neurotransmitters, such as Serotonin, which is derived from the Tryptophan. Different methods to improve the effect and performance of some drugs have been studied including the Nanoparticles. The objective was to analyze the efficacy of L-tryptophan and L-tryptophan Nanoparticles in the acute response of motor and cognitive behavior in an Alzheimer's experimental model. Methods: 15 Wistar rats, divided into 3 groups (n = 5): GC (Alzheimer's control group), GLt (L-tryptophan), and GN (Nanoparticles). They were treated for six consecutive days. Anxiety tests, spatial memory tests, aversive memory tests, and motor behavior tests were all performed during this study. In the analysis of anxiety, improvement was observed in both treatments, being that GN presented improvement in two variables: freezing (79±18.8; 74.6±14.2) and TBF (287.8±1.08; 268±40.8). GLt only presented improvement in freezing (103.8±44.4). In the spatial memory analysis, there HIGHLIGHTS• L-tryptophan and Nanoparticles in the motor and cognitive behavior in Alzheimer.• L-tryptophan Nanoparticles it lowers anxiety and improves motor behavior in Alzheimer.

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“…As the mechanism used by the active beta-amyloid peptide alters the motor behavior of animals, the animals remain in a state of stagnation, such as a depressive state. 24 In the effect size analysis, an improvement in the animals' Table 3. Comparative analysis between the phases of the Swimming and Alzheimer + Swimming groups for spatial memory.…”

Section: Discussionmentioning

confidence: 99%

Influence of Acute Physical Exercise on Cognitive and Motor Behavior in an Experimental Model of Alzheimer's Disease

Furmann

Rebesco

Smouter

et al. 2019

Rev Bras Med Esporte

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Introduction: Aging causes alterations in various executive and cognitive functions, mainly related to the incidence of dementia, especially Alzheimer's disease (AD). Several studies mention physical exercise as a preventive resource for depressive symptoms. Objective: To investigate the cognitive and behavioral alterations related to AD that are capable of slowing disease progression and its complications. Methods: The sample consisted of 10 male Wistar rats, divided into 2 groups (n = 5), swimming and Alzheimer + swimming, with a 6-day intervention protocol. The elevated plus maze test was used to assess anxiety, the Morris water maze for spatial memory, the isolation box for aversive memory, and the open field test to assay motor behavior. Results: There was improvement in spatial memory in the Swimming group (169 ± 142.9 x 24.2 ± 31.3), but motor behavior deteriorated after exercise. An increase in anxious behavior (8 ± 13.03 x 67.8 ± 48.1) was observed in the animals with AD. This is a relevant characteristic of the disease, which did not improve after acute exercise. By analyzing the size effect, it was possible to observe a difference in the Alzheimer + swimming group in terms of reduced anxiety and improved motor behavior after exercise. Despite the benefits of physical exercise for AD symptoms, there is still no consensus on the type of physical exercise and length of intervention necessary to achieve a positive response as a treatment method, since studies are yet to confirm this fact in an acute or chronic manner. Conclusion: Acute physical exercise was not fully effective as a means of treating behavioral alterations related to AD, but had a mean effect on the size effect analysis of motor behavior and anxiety, specifically. Level of evidence IV; Investigation of treatment outcomes.

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Estudo Do L-Triptofano Na Depressão Ocorrida Pela Doença De Alzheimer Em Modelos Experimentais

Cited by 10 publications

References 23 publications

Comparative Study of the Efficacy of L-Tryptophan Nanoparticles on Motor and Cognitive Behavior in an Alzheimer's Experimental Model

Influence of Acute Physical Exercise on Cognitive and Motor Behavior in an Experimental Model of Alzheimer's Disease

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