Antidepressant-like effects of an apolar extract and chow enriched with Nepeta cataria (catnip) in mice.

Bernardi, Maria Martha; Kirsten, Thiago Berti; Salzgeber, Simone Angélica; Ricci, Esther Lopes; Romoff, Paulete; Lago, João Henrique Guilardi; Lourenço, Lygia Mendes

doi:10.3922/j.psns.2010.2.015

Cited by 10 publications

(7 citation statements)

References 18 publications

(19 reference statements)

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“…Consistent with previous studies, we also found that chow enriched with NC has antidepressant properties in mice (Bernardi et al, 2010). Clinically, this finding could be very interesting because most antidepressant drugs induce sexual dysfunction and reduce the human and laboratory animals' libido (Baldwin, 2004;Habr et al, 2009).…”

Section: Discussionsupporting

confidence: 88%

Nepeta cataria L. var. citriodora (Becker) increases penile erection in rats

Bernardi

Kirsten

Lago

et al. 2011

Journal of Ethnopharmacology

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Section: Discussionsupporting

confidence: 88%

Nepeta cataria L. var. citriodora (Becker) increases penile erection in rats

Bernardi

Kirsten

Lago

et al. 2011

Journal of Ethnopharmacology

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“…EAE II as a non-polar extract treatment (at 100 mg kg −1 ) reduced the time of immobility in the FST, similar to the antidepressant fluoxetine (positive control), which is a selective serotonin reuptake inhibitor (Cryan et al, 2005; Science Publications Bernardi et al, 2010). Our non-polar extracts (CE II and EAE II) confirmed our results by Bernardi et al (2010).…”

Section: Discussionsupporting

confidence: 77%

Antidepressant-Like Effects of Selected Crude Extracts of Pilea microphylla in Mice Model of Depression

Chahardehi

Demirtaş

Abolhassani

et al. 2013

American Journal of Agricultural and Biological Sciences

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The present study was undertaken to investigate the effect of selected crude extracts namely, Methanol (ME I), Chloroform Extract (CE II) and Ethyl Acetate (EAE II) extracts of Pilea microphylla on depression in mice. In the present study, the antidepressant effect of P. microphylla was examined due to its rich flavonoid contents in the Urticaceae family using two behavioral models, the Forced Swimming Test (FST) and Tail Suspension Test (TST) in mice. Selected crude extracts from Pilea microphylla produced an antidepressant-like effect, since the acute treatment of mice with extracts by intraperitoneal (i.p.) route significantly reduced the immobility time in the FST (50 and 100 mg kg ), as compared to positive controls (haloperidol and fluoxetine) at 1 and 10 mg kg −1 , respectively. The results showed that ME I, CE II and EAE II at dose of 100 mg kg −1 of body weight decreased immobility time with the increase swimming time with respect to the first day (p<0.05). Among all the three selected extracts with two doses administered there were differences compared to the control group, EAE II led to reduction of immobility time, in the FST method by 38.50% for 50 mg kg −1 to as much as 75.97% for 100 mg kg −1 . Similar results of increased antidepressant effect, that was, of immobility time depending on the concentration administered, were obtained with the TST method. However, EAE II and CE II extract at dose of 100 mg kg −1 were obtained as best to choose an antideprssant activity. However, amounts of phenolic and flavonoid groups were found in CE II extract. As a conclusion treatment using selected crude extracts of P. microphylla had an antidepressant-like effect across models. Reduced immobility and decreasing freezing were observed in FST and TST tests. Therefore, P. microphylla may be served as a potential resource for natural psychotherapeutic agent against depression. The present study clearly demonstrated that Pilea microphylla exerts an antidepressant effect in these two behavioural models. It may be due to present of flavonoids. This is consistent with the hypothesis that enhanced uptake of flavonoids groups might have antidepressant-like effects. However, further studies are still required.

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“…Fifty-two rats (13 from each group; i.e., males and females from the control and LPS groups) were evaluated in the forced swim test 2 h after the LPS challenge on PND60-70. The test was performed as previously described (Bernardi et al, 2010; Schwarz, Gorniak, Bernardi, Dagli, & Spinosa, 2003). Briefly, in the adaptation session, the rats were individually placed in a glass cylinder (40 cm height, 22 cm diameter) that contained 25 cm of water at 20°C.…”

Section: Methodsmentioning

confidence: 99%

Neonatal lipopolysaccharide exposure induces sexually dimorphic sickness behavior in adult rats.

Bernardi

Teixeira

Oliveira

et al. 2014

Psychology & Neuroscience

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The aim of the present study was to evaluate whether neonatal exposure to lipopolysaccharide (LPS; 50 µg/kg, i.p., on postnatal day 2) induces depressive-and/or anxiety-like effects and sexually dimorphic responses in rats challenged with LPS (100 µg/kg, i.p.) in adulthood. The results revealed that males presented a less depressive state in the forced swim test and exhibited no changes in general motor activity in the open field test. Females exhibited an increase in sickness behavior, revealing different behavioral strategies in response to a bacterial disease. The male rats also exhibited higher cell proliferation, reflected by bone marrow and peripheral blood counts, and female rats exhibited a decrease in corticosterone levels. No changes were observed in the elevated plus maze or peripheral cytokine levels (interleukin-1β and tumor necrosis factor-α). Neonatal exposure to LPS induced sexually dimorphic behavioral, neuroendocrine, and immune effects after an LPS challenge in adulthood, differentially affecting male and female susceptibility to disease later in life.

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Antidepressant-like effects of an apolar extract and chow enriched with Nepeta cataria (catnip) in mice.

Cited by 10 publications

References 18 publications

Nepeta cataria L. var. citriodora (Becker) increases penile erection in rats

Nepeta cataria L. var. citriodora (Becker) increases penile erection in rats

Antidepressant-Like Effects of Selected Crude Extracts of Pilea microphylla in Mice Model of Depression

Neonatal lipopolysaccharide exposure induces sexually dimorphic sickness behavior in adult rats.

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