2020
DOI: 10.3892/ol.2020.12362
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Isobaric tags for relative and absolute quantitation‑based proteomics analysis of the effect of ginger oil on bisphenol A‑induced breast cancer cell proliferation

Abstract: Several chemicals in the environment, particularly those with estrogenic activity and small amounts (micromolar or lower) of environmental estrogen can cause changes in cell function and interfere with endocrine functions of animals and humans. These compounds enter the human body and increase the load of estrogen in the body, leading to an increasing incidence of estrogen-related tumors in breast cancer, ovarian cancer and endometrial cancer. Previous studies have demonstrated that ginger can inhibit the expr… Show more

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Cited by 9 publications
(1 citation statement)
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“…It has been recently shown that Zingiber officinale EO (GEO) inhibited the proliferation of BC MCF‐7 cells induced by bisphenol A (BPA), compound that promotes growth and metastasis of BC. Interestingly, a quantitative proteomics analysis of the cells treated with the combination of GEO and BPA demonstrated that changes caused in the oxidative phosphorylation pathway affected the tricarboxylic acid cycle and decreased the expression of SOD2 leading to oxidative stress and cell death (Lei et al, 2020). Erythrina corallodendron EO (ECEO) also suppressed the proliferation, migration, and invasion of MCF‐7 and MDA‐MB‐231 cells.…”
Section: Anticancer Activities Of Eos In In Vitro Bc Modelsmentioning
confidence: 99%
“…It has been recently shown that Zingiber officinale EO (GEO) inhibited the proliferation of BC MCF‐7 cells induced by bisphenol A (BPA), compound that promotes growth and metastasis of BC. Interestingly, a quantitative proteomics analysis of the cells treated with the combination of GEO and BPA demonstrated that changes caused in the oxidative phosphorylation pathway affected the tricarboxylic acid cycle and decreased the expression of SOD2 leading to oxidative stress and cell death (Lei et al, 2020). Erythrina corallodendron EO (ECEO) also suppressed the proliferation, migration, and invasion of MCF‐7 and MDA‐MB‐231 cells.…”
Section: Anticancer Activities Of Eos In In Vitro Bc Modelsmentioning
confidence: 99%