2020
DOI: 10.3892/ol.2020.11690
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Abstract: Endometrial carcinoma is one of the most common types of gynecological cancer. A total of 99 cases of primary endometrial carcinoma were investigated for survivin expression by immunohistochemistry. Furthermore, the association between concomitant survivin, PTEN and p53 expression, and clinicopathological parameters was examined. Immunopositivity for survivin was identified in 88% of cases. Concomitant survivin, PTEN and p53 expression (staining scores and intensity) was observed in 60% of endometrial adenocar… Show more

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Cited by 4 publications
(3 citation statements)
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“…Traditionally, prognostic factors for EC include surgical stage, histological factors [ 22 , 23 ], and molecular factors such as P53 mutation [ 24 ]. This information is often only available from histological evaluation after surgery, so preoperative risk assessment of recurrence is limited.…”
Section: Discussionmentioning
confidence: 99%
“…Traditionally, prognostic factors for EC include surgical stage, histological factors [ 22 , 23 ], and molecular factors such as P53 mutation [ 24 ]. This information is often only available from histological evaluation after surgery, so preoperative risk assessment of recurrence is limited.…”
Section: Discussionmentioning
confidence: 99%
“…Survivin can promote cell proliferation by inhibiting caspase activation and stabilizing microtubules during cell mitosis to protect cells from apoptosis (23). Previous studies have found that survivin is upregulated in a variety of human malignancies (24)(25)(26) and is associated with poor prognosis (27)(28)(29)(30), leading to proposals of survivin being used as a potential tumor marker and prognostic indicator. However, the significance of survivin in breast cancer progression remain controversial.…”
Section: Significance Of Combined Tgf-β1 and Survivin Expression On T...mentioning
confidence: 99%
“…For histological analysis routine staining with hematoxylin and eosin was used, and a pathologist confirmed the pathological diagnosis and identified areas of tumor mass. The phosphatase and tensin homologue deleted on chromosome 10 (PTEN), p53 and survivin immunohistochemical staining was performed and evaluated as described previously (69,70). Immunohistochemical staining for IGF-1Ec was performed as follows: 4-µm-thick microtome sections were prepared from the paraffin-fixed samples, making sure to include a sufficient quantity of neoplasm mass, which was mounted on a silane-coated glass slides, dried at 37˚C overnight, dewaxed in xylene and rehydrated in serial dilutions of ethanol.…”
Section: Patientsmentioning
confidence: 99%