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Cited by 21 publications
(13 citation statements)
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“…In a recent review, the authors have summarized the proposed antibacterial mode of action of flavonoids and structure-activity relationship, especially for MRSA, and it was noted that the chalcones showed an interesting effect even stronger than the standard drugs [47]. Chalcones with a lipophilic group such as isoprenoid and methoxy groups at positions 3′, 5′, and 2′ of ring A are the most potent inhibitors of MRSA strains [48, 49]. Diverse mechanisms of action of flavonoid group were exposed; for instance, baicalein has been demonstrated to be able to reverse the ciprofloxacin resistance of MRSA through NorA efflux pump inhibitory effect, and also the inhibition of virulence factors of MRSA such as pyruvate kinase could lead to a deficiency of ATP [50].…”
Section: Resultsmentioning
confidence: 99%
“…In a recent review, the authors have summarized the proposed antibacterial mode of action of flavonoids and structure-activity relationship, especially for MRSA, and it was noted that the chalcones showed an interesting effect even stronger than the standard drugs [47]. Chalcones with a lipophilic group such as isoprenoid and methoxy groups at positions 3′, 5′, and 2′ of ring A are the most potent inhibitors of MRSA strains [48, 49]. Diverse mechanisms of action of flavonoid group were exposed; for instance, baicalein has been demonstrated to be able to reverse the ciprofloxacin resistance of MRSA through NorA efflux pump inhibitory effect, and also the inhibition of virulence factors of MRSA such as pyruvate kinase could lead to a deficiency of ATP [50].…”
Section: Resultsmentioning
confidence: 99%
“…Example of these includes THIPMC ( 115 ) extracted from the plants of the genus Dorstenia (widely used in African and South American folk medicine for their pharmacological relevance) was active against tested bacteria alone as well as in combination with ampicillin or gentamicin. The MIC values (0.188 to 0.375 μg/ml) showed that the combined effect of this compound is greater than their individual effect (Lee et al, ). The investigation of bactericidal/bacteriolysis activities of flavonoid compounds by time‐kill kinetic method exhibited that 4‐hydroxyonchocarpin ( 118 ; Figure ) plays a greater role in increasing the antibacterial activity against S .…”
Section: Antibacterial Activity Of Flavonoidsmentioning
confidence: 99%
“…Also, hydroxy group at 4′, 4, and 6 of A and B rings increase the activity (Figure ). For example, between compounds kuraridin ( 168 ) and THIPMC ( 115 ) with the same structure, compound 168 with only one difference (with compound 115 ) in position of OH on the B ring (2 and 4 instead of 4 and 6) showed high activity against MRSA strain (Lee et al, ; Oh et al, ).…”
Section: Structure–activity Relationshipmentioning
confidence: 99%
“…Eryvarin W, a double prenylated pterocarpene from the roots of Erythrina variegata L., showed MICs of 1.56–3.13 µg/mL against MRSA strains, which lie in the range of the MIC values of vancomycin (MICs = 0.78 – 3.13 µg/mL) ( Tanaka et al, 2011 ). 7,9,2′,4′-Tetrahydroxy-8-isopentenyl-5-methoxychalcone, a prenylated chalcone from the roots of Sophora flavescens Ait., demonstrated excellent activity against MRSA and vancomycin-resistant enterococci (VRE) with MICs ranging from 1 to 8 µg/mL; in addition, the chalcone acted synergistically with ampicillin and gentamicin against MRSA and VRE ( Lee et al, 2010 ). α-Mangostin, a prenylated xanthone from Garcinia mangostana L. stem bark, inhibited the growth of VRE and MRSA (MIC = 6.25 and 6.25 – 12.5 µg/mL, respectively); moreover, it potentiated the activity of gentamicin and vancomycin against VRE and MRSA, respectively (synergistic interactions) ( Sakagami et al, 2005 ).…”
Section: Introductionmentioning
confidence: 99%