Effects of dietary xylo-oligosaccharide on growth performance, serum biochemical parameters, antioxidant function, and immunological function of nursery piglets

Hou, Zhenping; Duanqin, Wu; Dai, Qiuzhong

doi:10.37496/rbz4920190170

Cited by 6 publications

(9 citation statements)

References 27 publications

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“…Our results showed that either the high level or the low level of XOS failed to affect serum biochemical parameters in weaning pigs. Consistently, the previous studies indicated that serum biochemical parameters were not altered in XOS-treated weaning pigs or limited effect in XOS-treated nursery pigs ( 11 , 12 , 27 ).…”

Section: Discussionsupporting

confidence: 87%

“…The XOS had no impact on serum T-SOD, CAT, and T-AOC in our findings. Consistently, dietary addition of 400 mg/kg XOS markedly declined the serum MDA level and increased a trend of GSH-Px ( 12 ). Chen et al ( 13 ) also reported that piglets fed with the diet of 500 mg/kg XOS had higher T-SOD and CAT levels on day 28, whereas the MDA level was lower than the control group.…”

Section: Discussionmentioning

confidence: 84%

“…The immunoglobulins, including IgG, IgM, and IgA involve host immune response and protect against pathogens and virus infection. The previous studies showed that XOS can elevate the serum level of IgG in nursery pigs and IgM in broilers ( 12 , 29 ). Notably, with the level of XOS increased, the serum IgA had a linear increase and IgM showed linear and quadratic responses in laying hens ( 30 ).…”

Section: Discussionmentioning

confidence: 99%

“…Chen et al ( 4 , 13 ) found that an addition of 500 mg/kg XOS significantly increased BW, ADG, and decreased FCR in weaning piglets. Similarly, a dietary supplementation with 400 mg/kg XOS also increased final BW and ADG in nursery pigs, while ADFI and FCR were not affected ( 12 ). Additionally, a dietary supplementation of 250 mg/kg XOS markedly increased ADG and ADFI for weaning piglets ( 25 ).…”

Section: Discussionmentioning

confidence: 99%

“…The XOS are composed of 2-10 xylose monomers linked through β- (1,4) linkages with acidity and temperature stability, and non-toxicity (8)(9)(10). Many researches indicated that dietary supplementation of XOS improve the animal growth performance in weaning piglets and broiler chicken by enhancing immune functions, elevating antioxidant activity, increasing nutrient digestibility, and maintaining intestinal morphology and barrier (4,(11)(12)(13)(14). In addition, some studies found that XOS are able to increase short-chain fatty acids (SCFAs) concentrations in broiler chicken or weaning piglets (4,15), stimulate proliferation of Lactobacillus, and inhibit the growth of Escherichia coli in weaning piglets (4,16).…”

Section: Introductionmentioning

confidence: 99%

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The High Level of Xylooligosaccharides Improves Growth Performance in Weaned Piglets by Increasing Antioxidant Activity, Enhancing Immune Function, and Modulating Gut Microbiota

et al. 2021

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The aim of this study was to investigate the effects of the high level of xylooligosaccharides (XOS) on growth performance, antioxidant capability, immune function, and fecal microbiota in weaning piglets. The results showed that 28 d body weight exhibited linear and quadratic increases (P < 0.05) with increasing dietary XOS level, as well as average daily feed intake (ADFI) on d 15–28, average daily gain (ADG) on d 15–28 and 1–28. There was a linear decrease (P < 0.05) between XOS levels and feed conversion rate (FCR) on d 1–14 and 1–28. Additionally, glutathione peroxidase (GSH-Px) showed a linear increase (P < 0.05), while the malondialdehyde (MDA) level decreased linearly and quadratically (P < 0.05) with the increasing dietary level of XOS. Moreover, the XOS treatments markedly increased the levels of immunoglobulin A (Ig A) (linear, P < 0.05; quadratic, P < 0.05), IgM (quadratic, P < 0.05), IgG (linear, P < 0.05), and anti-inflammatory cytokine interleukin-10 (IL-10) (quadratic, P < 0.05) in serum, while the IL-1β (linear, P < 0.05; quadratic, P < 0.05) and IL-6 (linear, P < 0.05) decreased with increasing level of XOS. Microbiota analysis showed that dietary supplementation with 1.5% XOS decreased (P < 0.05) the α-diversity and enriched (P < 0.05) beneficial bacteria including Lactobacillus, Bifidobacterium, and Fusicatenibacter at the genus level, compared with the control group. Importantly, linearly increasing responses (P < 0.05) to fecal acetate, propionate, butyrate, and total short-chain fatty acids (SCFAs) were observed with increasing level of XOS. Spearman correlation analyses found that Lactobacillus abundance was positively correlated with ADG, acetate, propionate, and IgA (P < 0.05), but negatively correlated with IL-1β (P < 0.05). Bifidobacterium abundance was positively related with ADFI, total SCFAs, IgG, and IL-10 (P < 0.05), as well as g_Fusicatenibacter abundance with ADFI, total SCFAs, and IL-10. However, Bifidobacterium and Fusicatenibacter abundances were negatively associated with MDA levels (P < 0.05). In summary, dietary supplementation with XOS can improve the growth performance in weaning piglets by increasing antioxidant capability, enhancing immune function, and promoting beneficial bacteria counts.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The High Level of Xylooligosaccharides Improves Growth Performance in Weaned Piglets by Increasing Antioxidant Activity, Enhancing Immune Function, and Modulating Gut Microbiota

et al. 2021

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Xylooligosaccharide-mediated gut microbiota enhances gut barrier and modulates gut immunity associated with alterations of biological processes in a pig model

Tang

Chen

Deng

et al. 2022

Carbohydrate Polymers

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Effect of Arabinoxylan and Xylo-Oligosaccharide on Growth Performance and Intestinal Barrier Function in Weaned Piglets

Sun

et al. 2023

Animals

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The purpose of this study was to explore the effects of xylose with different polymerizations on growth performance, intestinal barrier function, and gut microbial composition in weaned piglets. A total of 144 weaned piglets were assigned to 3 dietary treatments in a completely randomized design according to their body weight and sex. Dietary treatments included a corn-soybean meal basal diet (CON) and 2 additional diets formulated with 1% arabinoxylan (AX) and 1% xylo-oligosaccharide (XOS), respectively. Results showed that dietary supplementation of XOS or AX reduced diarrhea incidence of weaned piglets compared with the CON group (p < 0.05). XOS or AX increased the ileal villus height and intestinal activity of antioxidases in weaned piglets compared with the CON group (p < 0.05). XOS or AX reduced the ileal and colonic IL-6 content and increased the colonic sIgA and IL-10 concentrations in weaned piglets compared with the CON group (p < 0.05). XOS or AX increased the total organic acids concentrations in the ileum and in vitro fermentation (p < 0.05). XOS increased the abundance of Lactobacillus and Bifidobacterium in the ileal digesta (p < 0.05), while AX increased the population of Lactobacillus in the ileal digesta and the abundance of Bifidobacterium in the colonic digesta of weaned piglets (p < 0.05). In conclusion, both XOS and AX reduce diarrhea incidence and improve antioxidant capacity, immune function, and populations of beneficial bacteria, while microbial fermentation of XOS with a lower polymerization and molecular mass can produce more organic acids and an increased abundance of Lactobacillus and Bifidobacterium in the upper gut of weaned pigs compared with AX.

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Effects of dietary xylo-oligosaccharide on growth performance, serum biochemical parameters, antioxidant function, and immunological function of nursery piglets

Cited by 6 publications

References 27 publications

The High Level of Xylooligosaccharides Improves Growth Performance in Weaned Piglets by Increasing Antioxidant Activity, Enhancing Immune Function, and Modulating Gut Microbiota

The High Level of Xylooligosaccharides Improves Growth Performance in Weaned Piglets by Increasing Antioxidant Activity, Enhancing Immune Function, and Modulating Gut Microbiota

Xylooligosaccharide-mediated gut microbiota enhances gut barrier and modulates gut immunity associated with alterations of biological processes in a pig model

Effect of Arabinoxylan and Xylo-Oligosaccharide on Growth Performance and Intestinal Barrier Function in Weaned Piglets

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