2022
DOI: 10.36660/abc.20210499
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Abstract: Resumo Fundamento: A (-)-carvona é um monoterpeno encontrado em óleos essenciais com atividade antioxidante e anti-inflamátoria. Objetivos: O objetivo deste estudo foi analisar a propriedade antiarrítmica da (-)-carvona no coração de rato e seus efeitos sobre a sinalização de Ca +2 intracelular. Métodos: Os efeitos da (-)-carvona foram avaliados sobre a contratilidade atrial (0,01 – 4 mM) e ventricular … Show more

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“…10 In this issue of the Arquivos Brasileiros de Cardiologia, the antiarrhythmic properties of the monoterpene (-)-Carvone was explored in vitro and ex vivo using diverse preparations that range from cellular assays to the isolated organ. 11 (-)-Carvone evoked a negative inotropic effect in the atria in a concentration-dependent fashion and reduced the contractility of isolated hearts after acute exposure to the terpene. The electrocardiogram (ECG) profile of isolated hearts exposed to this drug was marked with decreased heart rate, increased PR interval, and QTc.…”
mentioning
confidence: 94%
“…10 In this issue of the Arquivos Brasileiros de Cardiologia, the antiarrhythmic properties of the monoterpene (-)-Carvone was explored in vitro and ex vivo using diverse preparations that range from cellular assays to the isolated organ. 11 (-)-Carvone evoked a negative inotropic effect in the atria in a concentration-dependent fashion and reduced the contractility of isolated hearts after acute exposure to the terpene. The electrocardiogram (ECG) profile of isolated hearts exposed to this drug was marked with decreased heart rate, increased PR interval, and QTc.…”
mentioning
confidence: 94%