COVID-19 e o Coração

Strabelli, Tânia Mara Varejão; Uip, David Éverson

doi:10.36660/abc.20200209

Cited by 61 publications

(48 citation statements)

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“…It is estimated that 80% of the infected individuals develop mild or moderate forms of the infection while 20% manifest the severe version of the disease. Of these, 5% manifest the most severe form, which can rapidly progress to severe acute respiratory syndrome and other complications that may lead to death (3) .…”

Section: Introductionmentioning

confidence: 99%

The effect of suppressing funeral rituals during the COVID-19 pandemic on bereaved families

Cardoso

Silva

Santos

et al. 2020

Rev. Latino-Am. Enfermagem

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Objective amidst the greatest health crisis in history triggered by COVID-19, this documental study was intended to understand the meanings individuals who have lost loved ones in this context assign to the phenomenon of suppressed funeral rituals. Method based on the theory of grief, the corpus of this study was composed of documents published in digital media containing personal writings and reports of experiences freely and easily available to the public. Two researchers with expertise in the field used inductive thematic analysis to interpret data. Results the experiences shared in the reports reflect the suffering experienced by the sudden death of a significant person, which is amplified by the absence or impediment to performing familial farewell rituals. The suppression or abbreviation of funeral rituals is a traumatic experience because family members are prevented from fulfilling their last homage to the loved one who has suddenly passed away, causing feelings of disbelief and indignation. Conclusion alternatives and new ways to celebrate passage rituals in emergencies of strong social commotion such as a pandemic are needed to provide support and comfort to family members, friends, and relatives. These rituals help survivors to overcome the critical moment, decreasing the risk of developing complicated grief.

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Section: Introductionmentioning

confidence: 99%

The effect of suppressing funeral rituals during the COVID-19 pandemic on bereaved families

Cardoso

Silva

Santos

et al. 2020

Rev. Latino-Am. Enfermagem

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“…55 Biomarcadores como troponinas (responsáveis pela contração do músculo cardíaco), trombinas (responsáveis pela formação de coágulos) e peptídeo natriurético cerebral (marcador de resposta ao estresse do miocárdio devido a altos estiramentos e sobrecarga cardíaca) são encontrados em níveis elevados em pacientes graves de COVID-19 (Figura 2). 56 Em linhas gerais são propostos dois mecanismos de danos vasculares promovidos pela infecção pelo SARS-CoV-2. O primeiro, dito direto, é consequência da resposta imunitária citotóxica em decorrência da infecção viral.…”

Section: Aspectos Cardiovascularesunclassified

COVID-19: Physiopathology and Targets for Therapeutic Intervention

Almeida¹,

Oliveira²,

Avelar³

et al. 2020

Rev. Virtual Quim.

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The pandemic status of COVID-19 was recorded by the World Health Organization (WHO) on March 11, 2020. Since then, more than 10 million cases have been confirmed worldwide, with more than 500,000 reported deaths. Throughout this period, efforts by the global scientific community have focused on understanding the disease process and searching on preventive (e.g. vaccines) or therapeutic (e.g. drugs) alternatives of treatment for COVID-19. The present review portrays the historical aspects associated with the discovery of SARS-CoV-2, the etiological agent of COVID-19, describes the pathophysiological aspects of the disease, the viral replication process and discusses the main molecular targets subject to therapeutic intervention, aiming the design, discovery and development of new drugs to treat COVID-19. O status pandêmico da COVID-19 foi reconhecido pela Organização Mundial da Saúde (OMS) em 11 de março de 2020. Desde então mais de 20 milhões de casos foram confirmados no mundo, com mais de 900 mil mortes reportadas. Ao longo deste período a comunidade científica mundial tem debruçado esforços em entender o desenvolvimento da doença e buscar alternativas de tratamento preventivo (p. ex., vacinas) ou terapêutico (p. ex., fármacos) para a COVID-19. A presente revisão retrata os aspectos históricos associados a descoberta do SARS-CoV-2, agente etiológico da COVID-19, pontua o processo fisiopatológico da doença, as etapas de replicação viral e discute os alvos moleculares passíveis de intervenção terapêutica, visando o desenho, descoberta e desenvolvimento de fármacos para o tratamento da COVID-19.

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“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which has been assessed and characterized as a pandemic by world health organization on 11 March, 2020 (https://www.who.int/), causes coronavirus disease-19 (COVID-19) with in uenza-like manifestations ranging from mild disease to severe pneumonia, fatal acute lung injury, acute respiratory distress syndrome, multi-organ failure, and consequently resulting to high morbidity and mortality, especially in older patients with other comorbidities [1][2][3][4][5][6][7][8][9][10] . As of October 22, 2020, the ongoing COVID-2019 pandemic has swept through 212 countries and infected more than 40 932 220 individuals, posing an enormous burden to public health and an unprecedented effects to civil societies.…”

Section: Introductionmentioning

confidence: 99%

Transferrin receptor is another receptor for SARS-CoV-2 entry

Lai

Tang²,

Yang

et al. 2020

Preprint

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Angiotensin-converting enzyme 2 (ACE2) has been suggested as a receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) entry to cause coronavirus disease 2019 (COVID-19). However, no ACE2 inhibitors have shown definite beneficiaries for COVID-19 patients, applying the presence of another receptor for SARS-CoV-2 entry. Here we show that ACE2 knockout dose not completely block virus entry, while TfR directly interacts with virus Spike protein to mediate virus entry and SARS-CoV-2 can infect mice with over-expressed humanized transferrin receptor (TfR) and without humanized ACE2. TfR-virus co-localization is found both on the membranes and in the cytoplasma, suggesting SARS-CoV-2 transporting by TfR, the iron-transporting receptor shuttling between cell membranes and cytoplasma. Interfering TfR-Spike interaction blocks virus entry to exert significant anti-viral effects. Anti-TfR antibody (EC50 ∼16.6 nM) shows promising anti-viral effects in mouse model. Collectively, this report indicates that TfR is another receptor for SARS-CoV-2 entry and a promising anti-COVID-19 target.

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COVID-19 e o Coração

Cited by 61 publications

References 0 publications

The effect of suppressing funeral rituals during the COVID-19 pandemic on bereaved families

The effect of suppressing funeral rituals during the COVID-19 pandemic on bereaved families

COVID-19: Physiopathology and Targets for Therapeutic Intervention

Transferrin receptor is another receptor for SARS-CoV-2 entry

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