Síndrome de Takotsubo: Uma Doença Recorrente?

Fernandes, Fábio; Montera, Marcelo W.

doi:10.36660/abc.20200080

Cited by 3 publications

(2 citation statements)

References 10 publications

(19 reference statements)

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“…There are several factors that can predispose the development of Takotsubo syndrome, including the death of a loved one or even some trauma suffered by the patient [29], [30]. In comparison with the literature, the patients presented in this study had several risk factors, among which we can mention: female gender, post-menopause period and emotional stressor [27]- [31].…”

Section: Discussionmentioning

confidence: 85%

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Takotsubo Syndrome and Its Genetic Relationship: Case Report and Narrative Literature Review

Ferrari

Santos²,

Alvarenga³

et al. 2022

CLINICMED

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Introduction: Takotsubo Syndrome (TTS) is presented as a temporary loss of systolic function, it is usually associated with emotional or physical stress. However, its pathophysiology is not well defined. Thus, this article seeks the relationship between the genetic factor and the development of Takotsubo Syndrome. Methodology: The study is about a narrative review and two case reports on TTS. Results: TTS is related to the excess of catecholamines, and its genetic linkage is strongly considered due to recent studies where occasionally it has been noticed its hereditary connections, such as: increased cardiac sensitivity to catecholamines and cardiac vulnerability to adrenergic stressors, impaired regulation of norepinephrine release, syndrome fragile X, and CD36 deficiency. Discussion: There is still no conclusion of the leading factors to TTS. However, being female, being in the postmenopausal period, and exposed to stressful conditions are some of the risk factors that can develop the disease, and which are better accepted by the scientific community. Conclusions: Although TTS is a disease of low prevalence, it is increasingly present in the routine of the cardiologist. The great difficulty lies in its diagnosis as it does not present a pathognomonic symptom and it is similar to other diseases, such as ACS. This causes it to pass absent-mindedly during the emergency primary investigation. Thus, there is a need to expand studies related to this disease and to investigate its genetic association.

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Section: Discussionmentioning

confidence: 85%

“…Furthermore, the disease is more prevalent in postmenopausal women ages between 65 and 751. In addition, there are risk factors for the development of broken heart syndrome that are related to the quality of life of each patient, such as smoking, alcohol consumption, hyperlipidemia and anxiety [2], [4].…”

Section: Introductionmentioning

confidence: 99%

Takotsubo Syndrome and Its Genetic Relationship: Case Report and Narrative Literature Review

Ferrari

Santos²,

Alvarenga³

et al. 2022

CLINICMED

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The case of recurrent takotsubo syndrome on the background of coronary atherosclerosis

Maznev

Болдуева

Aronova³

et al. 2021

Kardiologiia

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Takotsubo syndrome (TS) is characterized with a reversible disorder of left ventricular contractility. At present time, it is established that various factors, both psycho-emotional and clinical, can trigger this disease. Notably, according to current opinions, coronary atherosclerosis may accompany TS and not be its exclusion criteria as it was previously thought. This article presents a clinical case of TS relapse in a female patient aged 83 years at 5 years following the first episode associated with progression of coronary atherosclerosis.

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A Síndrome de Takotsubo (Síndrome do coração partido): Aspectos hormonais

Lima

Paz

2021

RSD

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A síndrome de Takotsubo é tida como uma insuficiência cardíaca aguda reversível que é resultante do atordoamento miocárdico catecolaminérgico, tendo como principal sintomatologia a dor no peito e dispneia. O estudo objetivou buscar na literatura evidências sobre a influência hormonal no desencadeamento da síndrome de Takotsubo. Foi realizada uma revisão integrativa da literatura com busca na Biblioteca Virtual em Saúde (BVS), usando os descritores Cardiomiopatia de Takotsubo, Catecolaminas, diagnóstico; sendo inclusos artigos completos, disponíveis em português, inglês ou espanhol, publicados entre 2010 e 2020. Após análise criteriosa dos resultados obtidos, foram selecionados 10 estudos para compor a pesquisa. Os resultados mostraram uma forte relação entre a liberação hormonal e o desencadeamento da síndrome. As catecolaminas liberadas a partir de uma hiperestimulação do sistema hipotálamo-hipófise-adrenal exercem efeitos importantes na velocidade da contratilidade e força de contração do músculo cardíaco, resultando em perturbação da função cardíaca e aparecimento da síndrome. Conclui-se ainda que a liberação aumentada desses hormônios é estimulada principalmente por situações de estresse, como trauma emocional e estresse cirúrgico. Destaca-se a necessidade de mais estudos na área, como ensaios clínicos, que forneçam mais evidências dessa atuação hormonal no aparecimento da síndrome de Takotsubo, bem como a realização de estudos nacionais, tendo em vista que a grande maioria dos estudos são internacionais.

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Síndrome de Takotsubo: Uma Doença Recorrente?

Cited by 3 publications

References 10 publications

Takotsubo Syndrome and Its Genetic Relationship: Case Report and Narrative Literature Review

Takotsubo Syndrome and Its Genetic Relationship: Case Report and Narrative Literature Review

The case of recurrent takotsubo syndrome on the background of coronary atherosclerosis

A Síndrome de Takotsubo (Síndrome do coração partido): Aspectos hormonais

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Síndrome de Takotsubo: Uma Doença Recorrente?

Cited by 3 publications

References 10 publications

Takotsubo Syndrome and Its Genetic Relationship: Case Report and Narrative Literature Review

Takotsubo Syndrome and Its Genetic Relationship: Case Report and Narrative Literature Review

The case of recurrent tako­tsubo syndrome on the background of coronary atherosclerosis

A Síndrome de Takotsubo (Síndrome do coração partido): Aspectos hormonais

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The case of recurrent takotsubo syndrome on the background of coronary atherosclerosis