Aterosclerose, Inflamação e Genética – E Você Achava que Era Só Colesterol LDL

Gowdak, Luís Henrique Wolff

doi:10.36660/abc.20200038

Cited by 2 publications

(3 citation statements)

References 14 publications

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“…Atherosclerosis is the pathological basis of ACS. Recently, several studies have suggested that atherosclerosis is not a condition of simple lipid deposition but a chronic inflammatory disease ( 15 , 16 ). Inflammation plays a key role in the pathogenesis and progression of ACS ( 15-17 ), by mediating intracoronary thrombosis, atherosclerotic plaque damage, erosion and rupture ( 18 ).…”

Section: Discussionmentioning

confidence: 99%

“…Recently, several studies have suggested that atherosclerosis is not a condition of simple lipid deposition but a chronic inflammatory disease ( 15 , 16 ). Inflammation plays a key role in the pathogenesis and progression of ACS ( 15-17 ), by mediating intracoronary thrombosis, atherosclerotic plaque damage, erosion and rupture ( 18 ). Mononuclear cells in peripheral blood also have a crucial role in the development of atherosclerosis through activating vascular endothelial cells, as well as releasing inflammatory mediators, such as interleukin-1 and C-reactive protein ( 19 ).…”

Section: Discussionmentioning

confidence: 99%

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Protein tyrosine phosphatase receptor‑type O expression as a prognostic marker in patients with acute coronary syndrome undergoing percutaneous coronary intervention: A prospective study

2021

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Optimal clinical indicators are crucial for evaluating the prognosis of patients with acute coronary syndrome (ACS). In the present study, the potential prognostic value of protein tyrosine phosphatase receptor-type O (PTPRO) expression in the peripheral blood mononuclear cells of patients with ACS undergoing percutaneous coronary intervention (PCI) was investigated. Patients diagnosed with ACS were prospectively recruited, and PTPRO expression in mononuclear cells separated from peripheral blood was assessed by western blotting. The prognosis was judged by the occurrence of major adverse cardiovascular events. Cox regression analyses were performed to assess the association between PTPRO expression and prognosis. In the enrolled 185 patients with ACS, PTPRO expression was lower after PCI compared with that before PCI (P<0.05). Although the pre-PCI PTPRO expression did not differ significantly between the good and poor prognosis groups, PTPRO expression after PCI was significantly lower in the good prognosis group compared with the poor prognosis group (P<0.05). The area under the receiver operating characteristic curve for the prognostic value of post-PCI PTPRO expression was significantly greater than that for pre-PCI PTPRO expression (P<0.05). Cox regression analysis identified high post-PCI PTPRO expression as an independent risk factor for poor prognosis in patients with ACS (P<0.05), and further analysis indicated that the post-PCI PTPRO expression level was associated with the prognosis of patients with ACS (P<0.05). PTPRO expression in peripheral blood mononuclear cells after PCI is associated with the prognosis of patients with ACS, with high PTPRO expression indicating a high risk of poor prognosis in patients with ACS.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Protein tyrosine phosphatase receptor‑type O expression as a prognostic marker in patients with acute coronary syndrome undergoing percutaneous coronary intervention: A prospective study

2021

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“… 19 The CD4 + T lymphocytes in the atherosclerosis lesion are major consisted of Th1 and Th17 cells. 20 Natural Tregs, as an important subset of T lymphocytes, could regulate peripheral immune homeostasis by balancing the Th1, Th2 and Th17. So considerable reports confirmed that the suppressive function and frequency of nTregs had connection with the development of atherosclerosis lesion.…”

Section: Discussionmentioning

confidence: 99%

GARP and GARP-Treated tDC Prevented the Formation of Atherosclerotic Plaques in ApoE−/- Mice

Cai

Zeng

Liu³

et al. 2021

JIR

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Purpose This study aims to clarify the specific mechanism by which GARP affects the atherosclerotic plaques in ApoE −/- mice and the effect of GARP-tDC on atherosclerosis. Methods The mice were randomly divided into three groups: the control group, the GARP-overexpressed group and the GARP-inhibited group. After 12 weeks, all the mice were euthanized, and the specimens were collected. In vitro, experiments were conducted to observe the effect of GARP on DC phenotype and the changes of the proportion of CD4 + CD25 + Foxp3 + Treg cells when GARP-tDCs were co-cultured with CD4 + T cells. Furthermore, adoptive transmission of GARP-tDCs was used to observe the effect on atherosclerotic plaque in mice. Results The GARP-overexpressed group enhanced the biological activity of Foxp3 + CD4 + CD25 + Tregs and resulted in increased expression of LAP in T cells. In addition, the GARP-overexpressed group significantly suppressed the function of Th1 and Th17, and decreased the secretion of INF-γ and IL-17A. Thus, GARP had a protective effect on atherosclerosis. In vitro, we found that GARP-tDC had a tolerance-inducing phenotype, and GARP-tDC also had the ability to induce tolerance when co-cultured with CD4 + T cells. More importantly, adoptive transmission of GARP-tDCs reduced the size of atherosclerotic plaques. Conclusion GARP and the GARP-tDC play protective roles in atherosclerosis. The protective effect of GARP on atherosclerosis is achieved by increasing CD4 + CD25 + Foxp3 + Treg cells and inhibiting the production of IFN-γ and IL-17A.

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Aterosclerose, Inflamação e Genética – E Você Achava que Era Só Colesterol LDL

Cited by 2 publications

References 14 publications

Protein tyrosine phosphatase receptor‑type O expression as a prognostic marker in patients with acute coronary syndrome undergoing percutaneous coronary intervention: A prospective study

Protein tyrosine phosphatase receptor‑type O expression as a prognostic marker in patients with acute coronary syndrome undergoing percutaneous coronary intervention: A prospective study

GARP and GARP-Treated tDC Prevented the Formation of Atherosclerotic Plaques in ApoE−/- Mice

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