Influência do Consumo de Suco de Laranja (Citrus Sinensis) na Remodelação Cardíaca de Ratos Submetidos a Infarto do Miocárdio

Oliveira, Bruna Camargo; Santos, Priscila P.; Figueiredo, Amanda Menezes; Ishikawa, Larissa Lumi Watanabe; Zanati, Silméia Garcia; Fernandes, Ana Angélica Henrique; Azevedo, Paulo Furquim de; Polegato, Bertha Furlan; Zornoff, Leonardo A. M.; Minicucci, Marcos F.; Paiva, Sérgio Alberto Rupp de

doi:10.36660/abc.20190397

Cited by 7 publications

(3 citation statements)

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“…Oranges are generally rich in vitamin C and flavonoids, which support antioxidant activities. We found two studies that evaluated the effect of orange juice supplementation in models of MI and doxorubicin [ 59 , 60 ]. One of these studies evaluated different orange juices, including Pear and Moro.…”

Section: Phytochemicals/phytonutrientsmentioning

confidence: 99%

Role of Nutrients and Foods in Attenuation of Cardiac Remodeling through Oxidative Stress Pathways

et al. 2022

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Cardiac remodeling is defined as a group of molecular, cellular, and interstitial changes that manifest clinically as changes in the heart’s size, mass, geometry, and function after different injuries. Importantly, remodeling is associated with increased risk of ventricular dysfunction and heart failure. Therefore, strategies to attenuate this process are critical. Reactive oxygen species and oxidative stress play critical roles in remodeling. Importantly, antioxidative dietary compounds potentially have protective properties against remodeling. Therefore, this review evaluates the role of nutrients and food as modulators of cardiac remodeling.

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Section: Phytochemicals/phytonutrientsmentioning

confidence: 99%

Role of Nutrients and Foods in Attenuation of Cardiac Remodeling through Oxidative Stress Pathways

et al. 2022

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“…Similar results were found with açai seed extract in the renovascular hypertension animal model and obese high-fat diet-fed mice, demonstrating a protective effect in cardiovascular diseases probably due to its antioxidant properties [ 43 , 44 ]. Orange juice ( Citrus sinensis ), grape seed extract, and jaboticaba ( Myrciaria jaboticaba ), fruits with antioxidant components, also attenuated cardiac remodeling after myocardial infarction in rats [ 46 , 47 , 48 ].…”

Section: Evidence Of Oxidative Stress As a Therapeutic Target Against...mentioning

confidence: 99%

Oxidative Stress as a Therapeutic Target of Cardiac Remodeling

et al. 2022

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Cardiac remodeling is defined as a group of molecular, cellular, and interstitial changes that clinically manifest as changes in the heart’s size, mass, geometry, and function after different stimuli. It is important to emphasize that remodeling plays a pathophysiological role in the onset and progression of ventricular dysfunction and subsequent heart failure. Therefore, strategies to mitigate this process are critical. Different factors, including neurohormonal activation, can regulate the remodeling process and increase cell death, alterations in contractile and regulatory proteins, alterations in energy metabolism, changes in genomics, inflammation, changes in calcium transit, metalloproteases activation, fibrosis, alterations in matricellular proteins, and changes in left ventricular geometry, among other mechanisms. More recently, the role of reactive oxygen species and oxidative stress as modulators of remodeling has been gaining attention. Therefore, this review assesses the role of oxidative stress as a therapeutic target of cardiac remodeling.

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“…15 Embora os efeitos anti-inflamatórios e antioxidantes do suco de laranja sejam conhecidos há longo tempo, não havia estudo sobre seu efeito na remodelação cardíaca induzida por infarto do miocárdio. Oliveira et al, 16 observaram que a suplementação com suco de laranja aumenta a expressão da heme-oxygenase-1, enzima crucial na homeostasia celular com efeitos anti-inflamatórios, antioxidante e anti-apoptótico. DOI: https://doi.org/10.36660/abc.20220186…”

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