Malignant pleural mesothelioma: an update

Hajj, Glaucia Noeli Maroso; Cavarson, Carolina Harumi; Pinto, Clóvis Antônio Lopes; Venturi, Gabriela; Navarro, João R; Lima, Vladmir Cláudio Cordeiro de

doi:10.36416/1806-3756/e20210129

Cited by 17 publications

(18 citation statements)

References 173 publications

(218 reference statements)

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“…Saitoh et al [23] reported 2 patients diagnosed as malignant peritoneal mesothelioma [15] and 3 patients from the general population (control cases) who died from other causes. The cases were 2 males and 3 females.…”

Section: Resultsmentioning

confidence: 99%

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Quantitative Assessment of Asbestos Fibers in Normal and Pathological Peritoneal Tissue—A Scoping Review

Caraballo-Arias

Zunarelli

Caffaro

et al. 2022

Life

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Peritoneal tissue is the second most affected site by malignant mesothelioma linked to asbestos exposure. This scoping review aims to summarize the findings of the studies in which asbestos fibers in the peritoneum were quantified by electron microscopy, occasionally associated with spectroscopy, both in neoplastic and non-neoplastic tissue. The 9 studies selected comprised 62 cases, out of whom 100 samples were analyzed. Asbestos fibers were detected in 58 samples (58%). In addition, 28 cases had diagnosis of peritoneal mesothelioma. For 32 cases, a lung tumor sample was available: 28/32 samples analyzed presented asbestos fibers; 18/32 reported amphiboles with a range from not detected to 14.2 million fibers per gram of dry tissue (mfgdt); 18/32 reported chrysotile, with a range of 0 to 90 mfgdt. The studies were heterogeneous for type of samples, analytical technology, and circumstances of exposure to asbestos. To evaluate asbestos fibers in the peritoneum and to better understand the association between asbestos exposure and malignant peritoneal mesothelioma, it is desirable that the search for asbestos fibers becomes a routine process every time peritoneal tissue is accessible.

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Section: Resultsmentioning

confidence: 99%

“…Malignant mesothelioma is linked to exposure to asbestos in a large proportion of cases, most of which concern pleural tissue (73-85%), with the peritoneum being the second most affected site (7-18% of total cases) [7,15].…”

Section: Introductionmentioning

confidence: 99%

Quantitative Assessment of Asbestos Fibers in Normal and Pathological Peritoneal Tissue—A Scoping Review

Caraballo-Arias

Zunarelli

Caffaro

et al. 2022

Life

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“…Current investigations in the realm of CPIs encompass not only those targeting T-cell responses or activating T-cell pathways but also the utilization of cytokines such as IL-12 and IL-15, therapeutic vaccines, ablation of immunosuppressive cells, and modulation of other constituents of the immune cascade. 11 …”

Section: Immune Checkpoint Inhibitors (Cpis)mentioning

confidence: 99%

Advances in Immunotherapy for Malignant Pleural Mesothelioma: From Emerging Strategies to Translational Insights

López-Castro,

Fuentes-Martín,

Medina del Valle

et al. 2024

Open Respiratory Archives

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“…1 The malignant potential of asbestos fibres lies within their capability to deeply infiltrate the respiratory system and persist there for extended durations. 2 There is no known safe level of asbestos exposure. 3 …”

Section: Introductionmentioning

confidence: 99%

Telomere length and TERT polymorphisms as biomarkers in asbestos-related diseases

Mervic,

Goricar,

Blagus

et al. 2024

Radiology and Oncology

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Background Asbestos exposure has been proposed as a risk factor for shorter telomere length. The aim of our study was to investigate whether telomere length in leukocytes and hTERT genetic polymorphisms may serve as potential biomarkers for the risk of developing asbestos-related diseases and as biomarkers of progression and chemotherapy response rate in malignant mesothelioma (MM). Subjects and methods We conducted two retrospective studies. In the first study, a case-control study, telomere length and hTERT polymorphisms were determined in patients with MM, subjects with pleural plaques and controls without the asbestos related disease, who were occupationally exposed to asbestos. In the second study, a longitudinal observational study, telomere length was also determined in samples from MM patients before and after chemotherapy. Telomere length was determined by monochromatic multiplex quantitative polymerase chain reaction (PCR), while competitive allele-specific PCR was used to genotype hTERT rs10069690, rs2736100 and rs2736098. Logistic regression and survival analysis were used in statistical analysis. Results Patients with MM had shorter telomere length than subjects with pleural plaques (p < 0.001). After adjustment for age, rs2736098 CT, and rs10069690 TT and CT+TT genotypes were significantly associated with a higher risk of MM (padj = 0.023; padj = 0.026 and padj = 0.017), while rs2736100 AA and CA+AA genotypes conferred to a lower risk for MM compared to all other subjects (padj = 0.017, and padj = 0.026). Telomere length was not associated with a response to chemotherapy (p > 0.05) or time to disease progression (p > 0.05). Carriers of one or two polymorphic rs10069690 T alleles had a good response to chemotherapy (p = 0.039, and p = 0.048), these associations remained statistically significant after adjustment for age (padj = 0.019; padj = 0.017). Carriers of two polymorphic rs2736100 A alleles had a longer time to disease progression (p = 0.038). Conclusions Shorter telomere length and hTERT polymorphisms may serve as a biomarker for the risk of developing MM. Additionally, rs10069690 and rs2736100 polymorphisms, but not telomere length, were associated with a chemotherapy response or MM progression.

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Malignant pleural mesothelioma: an update

Cited by 17 publications

References 173 publications

Quantitative Assessment of Asbestos Fibers in Normal and Pathological Peritoneal Tissue—A Scoping Review

Quantitative Assessment of Asbestos Fibers in Normal and Pathological Peritoneal Tissue—A Scoping Review

Advances in Immunotherapy for Malignant Pleural Mesothelioma: From Emerging Strategies to Translational Insights

Telomere length and TERT polymorphisms as biomarkers in asbestos-related diseases

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