Evaluation of the left ventricle in patients with COPD and nocturnal hypoxemia

Prados, Victória Oliveira; Lima, Talita; Silva, Larissa Tavares da; Matos, Isadora Coelho; Maya, Ana Carolina Lobato; Júnior, José Laerte Rodrigues Silva; Rabahi, Marcelo Fouad

doi:10.36416/1806-3756/e20190136

Cited by 2 publications

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“…In addition, intermittent hypoxia was shown to be significantly associated with higher values of LVM and LVM index (LVMI) in patients with obstructive sleep apnea-hypopnea syndrome [14]. Moreover, in a study of patients with chronic obstructive pulmonary disease, those with significant nocturnal hypoxemia had increased LVM compared with those with mild daytime hypoxemia [15]. These findings indicate that LV hypertrophy occurs in patients with nocturnal hypoxemia.…”

Section: Discussionmentioning

confidence: 95%

Reversible cardiac function and left ventricular hypertrophy in a Chinese man with mitochondrial myopathy: a case report

Wu,

Han,

Zhao

et al. 2023

BMC Cardiovasc Disord

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Background Mitochondrial myopathies (MMs) are a group of multi-system diseases caused by abnormalities in mitochondrial DNA (mtDNA) or mutations of nuclear DNA (nDNA). The diagnosis of mitochondrial myopathy (MM) is reliant on the combination of history and physical examination, muscle biopsy, histochemical studies, and next-generation sequencing. Patients with MMs have diverse clinical manifestations. In the contemporary literature, there is a paucity of reports on cardiac structure and function in this rare disease. We report a Chinese man with MM accompanied with both acute right heart failure and left ventricular hypertrophy. Case presentation A 49-year-old man presented with clinical features suggestive of MM, i.e., ophthalmoparesis, weakness of the pharyngeal and extremity muscles, and respiratory muscles which gradually progressed to respiratory insufficiency. He had a family history of mitochondrial myopathy. He had increased levels of serum creatine kinase and lactate. Muscle biopsy of left lateral thigh revealed 8% ragged red fibers (RRF) and 42% COX-negative fibers. Gene sequencing revealed a novel heterozygote TK2 variant (NM_001172644: c.584T>C, p.Leu195Pro) and another heterozygous variant (NM_004614.4:c.156+958G>A; rs1965661603) in the intron of TK2 gene. Based on these findings, we diagnosed the patient as a case of MM. Echocardiography revealed right heart enlargement, pulmonary hypertension, left ventricular hypertrophy, and thickening of the main pulmonary artery and its branches. The patient received non-invasive ventilation and coenzyme Q10 (CoQ10). The cardiac structure and function were restored at 1-month follow-up. Conclusions This is the first report of reversible cardiac function impairment and left ventricular hypertrophy in a case of adult-onset MM, nocturnal hypoxia is a potential mechanism for left ventricular hypertrophy in patients with MM.

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Section: Discussionmentioning

confidence: 95%

Reversible cardiac function and left ventricular hypertrophy in a Chinese man with mitochondrial myopathy: a case report

Wu,

Han,

Zhao

et al. 2023

BMC Cardiovasc Disord

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“…HFNC is widely used in foreign countries and relatively few in China. It is a new type of noninvasive respiratory support method, and its tolerance and comfort are very good [7]. e researchers of Yuste et al [8] compared the clinical effects of HFNC and continuous noninvasive ventilator-assisted breathing in the treatment of COPD with respiratory failure and found that the respiratory rate, heart rhythm, and total clinical efficiency of patients with HFNC had significant effects, and the adverse reactions were low.…”

Section: Introductionmentioning

confidence: 99%

Artificial Intelligence-Based Computed Tomography Imaging Characteristics for the Diagnosis Effect of High Flow Nasal Cannula in the Treatment of Patients with Advanced Lung Cancer and Chronic Obstructive Pulmonary Disease

Tang

Yuan

2021

Scientific Programming

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Objective. This study was to compare the effects of symptomatic treatment and high flow nasal cannula (HFNC) treatment on patients with advanced lung cancer complicated with chronic obstructive pulmonary disease (COPD) and to explore the clinical application effect of HFNC treatment in such patients. Methods. 80 patients with advanced lung cancer and COPD admitted to the hospital were selected as the research objects. They were randomly divided into a control group (n = 40) and an observation group (n = 40). The computed tomography (CT) image data of all patients were classified. The neural network was trained to obtain the network weights. Based on surgery, radiotherapy, and chemotherapy, patients in the control group received anti-inflammatory, phlegm, and other symptomatic treatments, while patients in the observation group received HFNC treatment on this basis. The blood gas analysis results, clinical symptoms (cough, wheezing, rales, etc.), inflammatory factors (high-sensitivity C-reactive protein (hs-CRP), plateletcrit (PCT), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6)), and quality of life of the two groups were compared and analyzed. Results. When the model MSE was the smallest, the corresponding hidden layer neuron node value was 49, so 49 was set as the optimal number of hidden layer neuron nodes. CT images were imported into the constructed model system, and the model diagnosis system could still diagnose and classify under the premise that the pathological characteristics were not obvious. There was no significant difference in clinical data between the two groups of patients before treatment ( P > 0.05 ). After treatment, the clinical symptoms, arterial partial pressure of carbon dioxide (PaCO2), arterial partial pressure of oxygen (PaO2), hs-CRP, PCT, TNF-α, and IL-6 levels were greatly reduced; those of patients in the observation group were much better in contrast to those of the control group ( P < 0.05 ). The total effective rate in the observation group was 97.5%, and the effective rate in the control group was 87.5%. After treatment, the functional assessment of cancer therapy-lung (FACT-L) score was obviously higher than that before treatment ( P < 0.05 ). After treatment, the quality of life in the observation group was increased by 45.69% compared with that before treatment, and the quality of life in the control group was increased by 35.77%. Conclusion. HFNC therapy can improve the lung function of patients with advanced lung cancer and COPD, alleviate the development of the disease, and improve the quality of life of patients.

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Evaluation of the left ventricle in patients with COPD and nocturnal hypoxemia

Cited by 2 publications

References 0 publications

Reversible cardiac function and left ventricular hypertrophy in a Chinese man with mitochondrial myopathy: a case report

Reversible cardiac function and left ventricular hypertrophy in a Chinese man with mitochondrial myopathy: a case report

Artificial Intelligence-Based Computed Tomography Imaging Characteristics for the Diagnosis Effect of High Flow Nasal Cannula in the Treatment of Patients with Advanced Lung Cancer and Chronic Obstructive Pulmonary Disease

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