Smoking history: relationships with inflammatory markers, metabolic markers, body composition, muscle strength, and cardiopulmonary capacity in current smokers

Gouveia, Tamara dos Santos; Trevisan, Iara Buriola; Santos, Caroline Pereira; Silva, Bruna Spolador de Alencar; Ramos, Ercy Mara Cípulo; Proença, Mahara; Ramos, Dionei

doi:10.36416/1806-3756/e20180353

Cited by 6 publications

(5 citation statements)

References 32 publications

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“…As concerns the mechanism, research has suggested that nicotine negatively affects insulin sensitivity in skeletal muscle and increases lipolysis 66,67 . A history of smoking was found to be correlated with fat mass and waist circumference 68,69 . Cigarette smoking also correlated with FMR in our study.…”

Section: Discussionmentioning

confidence: 99%

Association of fat-to-muscle mass ratio with physical activity and dietary protein, carbohydrate, sodium, and fiber intake in a cross-sectional study

Nishikori,

Fujita

2024

Sci Rep

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Higher fat-to-muscle mass ratio (FMR) is reported to be a risk factor for various diseases, including type 2 diabetes and cardiovascular diseases, and mortality. Although this association suggests that reducing FMR may help to prevent certain diseases and mortality, the relationship between FMR and lifestyle factors is unclear. Therefore, we performed a cross-sectional study with the aim to elucidate this relationship. This cross-sectional study included 1518 healthy Japanese adults aged 30 to 64 years. We measured FMR in the whole body, arms, legs, and trunk and assessed various lifestyle factors. Then, we performed forced entry multiple regression analyses for FMR with the following variables: sex, age, physical activity, dietary intake, sleep quality, cigarette smoking, stress levels, and body mass index. As a result, whole-body and regional FMRs were correlated with female sex (β = 0.71); age (β = 0.06); physical activity (β = − 0.07); dietary intake of protein (β = − 0.12), carbohydrate (β = 0.04), sodium (β = 0.13), and fiber (β = − 0.16); and body mass index (β = 0.70). The results suggest that in the Japanese middle-aged population, low FMR is associated with certain lifestyle factors, i.e. higher physical activity and a diet with higher protein and fiber and lower carbohydrate and sodium, independent of age, sex, and body mass index.

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Section: Discussionmentioning

confidence: 99%

Association of fat-to-muscle mass ratio with physical activity and dietary protein, carbohydrate, sodium, and fiber intake in a cross-sectional study

Nishikori,

Fujita

2024

Sci Rep

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“…As concerns the mechanism, research has suggested that nicotine negatively affects insulin sensitivity in skeletal muscle and increases lipolysis 51,52 . A history of smoking was found to be correlated with fat mass and waist circumference 53,54 .…”

Section: Discussionmentioning

confidence: 99%

Fat-to-muscle mass ratio is associated with physical activity and dietary intake of protein, carbohydrate, sodium, and fiber, independent of sex, age, and body mass index: a cross-sectional study

Fujita,

Nishikori

2023

Preprint

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Higher fat-to-muscle mass ratio (FMR) is reported to be a risk factor for various diseases, including type 2 diabetes and cardiovascular diseases, and mortality. Although this association suggests that reducing FMR may help to prevent certain diseases and mortality, the relationship between FMR and lifestyle factors is unclear. Therefore, we performed a cross-sectional study with the aim to elucidate this relationship. This cross-sectional study included 1,518 healthy Japanese adults aged 30 to 64 years. We measured FMR in the whole body, arms, legs, and trunk and assessed various lifestyle factors. Then, we performed forced entry multiple regression analyses for FMR with the following variables: sex, age, physical activity, dietary intake, sleep quality, cigarette smoking, stress levels, and body mass index. As a result, whole-body and regional FMRs were correlated with female sex (b = 0.71); age (b = 0.06); physical activity (b = -0.07); dietary intake of protein (b = -0.12), carbohydrate (b = 0.04), sodium (b = 0.13), and fiber (b = -0.16); and body mass index (b = 0.70). The results suggest that in the Japanese middle-aged population, FMR is associated with certain lifestyle factors, i.e., higher physical activity and a diet with higher protein and fiber and lower carbohydrate and sodium, independent of age, sex, and body mass index.

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“…This is similar to a recent cross-sectional study of smokers (r=0.308). 38 Stimulating effects of chronic smoking on the bone marrow have been shown to increase 1) the size of the mitotic and postmitotic pools of leukocytes and 2) the transition out of the postmitotic pool. 39 A higher plasma level of granulocyte-colony stimulating factor in smokers increases myelopoiesis and circulating monocytosis.…”

Section: Discussionmentioning

confidence: 99%

Cigarette Smoking, and Blood Monocyte Count Correlate with Chronic Lung Injuries and Mortality

Sangani¹,

Deepak²,

Anwar³

et al. 2023

COPD

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Background Cigarette smoking (CS)-related monocytosis contributes to the development of chronic lung injuries via complex mechanisms. We aim to determine correlations between measures of CS and monocytes, their capacities to predict chronic lung diseases, and their associations with mortality. Methods A single-center retrospective study of patients undergoing surgical resection for suspected lung nodules/masses was performed. CS was quantified as cigarettes smoked per day (CPD), duration of smoking, composite pack years (CPY), current smoking status, and smoking cessation years. A multivariate logistic regression analysis was performed. Results Of 382 eligible patients, 88% were ever smokers. In this group, 45% were current smokers with mean CPD of 27.2±40.0. CPY and duration of smoking showed positive linear correlations with percentage monocyte count. Physiologically, CPY was associated with progressive obstruction, hyperinflation, and reduced diffusion capacity (DL CO ). Across the quartiles of smoking, there was an accumulation of radiologic and histologic abnormalities. Anthracosis and emphysema were associated with CPD, while lung cancer, respiratory bronchiolitis (RB), emphysema, and honeycombing were statistically related to duration of smoking. Analysis using consecutive CPY showed associations with lung cancer (≥10 and <30), fibrosis (≥20 and <40), RB (≥50), anthracosis and emphysema (≥10 and onwards). Percentage monocytes correlated with organizing pneumonia (OP), fibrosis, and emphysema. The greater CPY increased mortality across the groups. Significant predictors of mortality included percentage monocyte, anemia, GERD, and reduced DL CO . Conclusion Indices of CS and greater monocyte numbers were associated with endpoints of chronic lung disease suggesting a participation in pathogenesis. Application of these easily available metrics may support a chronology of CS-induced chronic lung injuries. While a relative lesser amount of smoking can be associated with lung cancer and fibrosis, greater CPY increases the risk for emphysema. Monocytosis predicted lung fibrosis and mortality. Duration of smoking may serve as a better marker of monocytosis and associated chronic lung diseases.

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Smoking history: relationships with inflammatory markers, metabolic markers, body composition, muscle strength, and cardiopulmonary capacity in current smokers

Cited by 6 publications

References 32 publications

Association of fat-to-muscle mass ratio with physical activity and dietary protein, carbohydrate, sodium, and fiber intake in a cross-sectional study

Association of fat-to-muscle mass ratio with physical activity and dietary protein, carbohydrate, sodium, and fiber intake in a cross-sectional study

Fat-to-muscle mass ratio is associated with physical activity and dietary intake of protein, carbohydrate, sodium, and fiber, independent of sex, age, and body mass index: a cross-sectional study

Cigarette Smoking, and Blood Monocyte Count Correlate with Chronic Lung Injuries and Mortality

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