2019
DOI: 10.3390/nano9010130
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Abstract: At the onset of cancer, specific biomarkers get elevated or modified in body fluids or tissues. Early diagnosis of these biomarkers can greatly improve the survival rate or facilitate effective treatment with different modalities. Potential nanomaterial-based biosensing and bioimaging are the main techniques in nanodiagnostics because of their ultra-high selectivity and sensitivity. Emerging graphene, including two dimensional (2D) graphene films, three dimensional (3D) graphene architectures and graphene hybr… Show more

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Cited by 50 publications
(20 citation statements)
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References 181 publications
(159 reference statements)
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“…However, a univocal classification of G broad family and their correlation with biosensing properties are challenging. Thus, the different synthetic approaches have been adopted for G preparation; the not homogeneous G nature (complexes structures with several oxidation states, varied lateral sizes, different number of layers, and different colloidal stability); the presence of impurities (often metal impurities); the formation of nanocomposites by a combination of G with organic or inorganic compounds have been taken in consideration for graphene-based biosensing applications [ 10 ].…”
Section: Graphene Nanomaterialsmentioning
confidence: 99%
“…However, a univocal classification of G broad family and their correlation with biosensing properties are challenging. Thus, the different synthetic approaches have been adopted for G preparation; the not homogeneous G nature (complexes structures with several oxidation states, varied lateral sizes, different number of layers, and different colloidal stability); the presence of impurities (often metal impurities); the formation of nanocomposites by a combination of G with organic or inorganic compounds have been taken in consideration for graphene-based biosensing applications [ 10 ].…”
Section: Graphene Nanomaterialsmentioning
confidence: 99%
“…Until now, numerous works have been published investigating the use of nanomaterials to environmental applications [ 44 , 45 , 46 , 47 , 48 , 49 ]. In contrast, the most pressing challenge is application of nanotechnology to design of multifunctional, structured materials able to target specific diseases and protection of therapeutic moieties [ 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 ]. Functionalities to allow transport across biological barriers and to realize the desired clinical benefits rapidly via understanding of toxicological implications of nanomedicines relate to the specific nanoscale properties [ 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 ].…”
Section: Introductionmentioning
confidence: 99%
“…Two-dimensional allotropes of carbon are materials that have been used for their interesting properties and their ability to form diverse sp, sp 2 , and sp 3 bonds [1]. Graphene (G) and graph-n-yne are 2D materials that have been widely studied [2][3][4][5]. Graphene is a material that was discovered by Andre Gaim and Konstantin Novoselov in 2004 by the exfoliation method; graphene consists of a hexagonal (honeycomb) lattice of covalently bound sp 2 carbon atoms ( Fig.…”
Section: Introductionmentioning
confidence: 99%
“…Mientras que las funciones de fukui, la suavidad local y el potencial electrostático molecular son los descriptores de reactividad local. Los resultados sugieren que la hibridación de los carbonos en los derivados se mantiene cerca de sp 3 , mientras que para el grafeno es sp 2 , los cambios de simetría tienen como consecuencia cambios en su comportamiento químico. Descubrimos que el dopaje con B o P (uno o dos átomos dopados) y la funcionalización con grupos -OH o -COOH (como en el óxido de grafeno), disminuye la…”
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