Indomethacin Inhibits Cancer Cell Migration via Attenuation of Cellular Calcium Mobilization

Guo, Yuh Cherng; Chang, Che Mai; Hsu, Wen Li; Chiu, Siou Jin; Tsai, Yao Ting; Chou, Yii Her; Hou, Ming‐Feng; Wang, Jaw Yan; Lee, Mei Hsien; Tsai, Ke Li; Chang, Wei Chiao

doi:10.3390/molecules18066584

Cited by 48 publications

(27 citation statements)

References 28 publications

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“…Considering the concept of metal ion mimicry, calcium channels are very likely to be transducers of nickel. Indeed, calcium channels have been considered as important mediators of inflammatory gene activation Wang et al, 2012;Yang et al, 2013;Guo et al, 2013). In addition, pretreatment with the calcium channel blockers, verapamil and nicardipine, decreased nickel uptake by 20% (Funakoshi et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

Involvement of L‐type Ca²⁺ channel and toll‐like receptor‐4 in nickel‐induced interleukin‐8 gene expression

Lin

Chung

Wong

et al. 2014

Environmental Toxicology

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The metal nickel (Ni(2+)) is found everywhere in our daily lives, including coins, costume jewelry, and even nuts and chocolates. Nickel poisoning can cause inflammatory reactions, respiratory diseases, and allergic contact dermatitis. To clarify the mechanism by which nickel induces mediators of inflammation, we used the human acute monocytic leukemia THP-1 cell line as a model. Interleukin (IL)-8 promoter activity as well as gene expression were tested by luciferase assay and real-time polymerase chain reaction. The underlying mechanisms of nickel-induced IL-8 were investigated. We found that nickel induced IL-8 gene expression via the L-type Ca(2+) channel, Toll-like receptor-4 (TRL-4) and nuclear factor NF-κB signal transduction pathways. Nickel activated NF-κB expression through extracellular signal-regulated kinase 1/2 phosphorylation and then increased IL-8 expression. Thus, the L-type Ca(2+) channel and TRL-4 play important roles in nickel-induced inflammatory gene expressions.

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Section: Discussionmentioning

confidence: 99%

Involvement of L‐type Ca²⁺ channel and toll‐like receptor‐4 in nickel‐induced interleukin‐8 gene expression

Lin

Chung

Wong

et al. 2014

Environmental Toxicology

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“…[139] It has also been associated with increased tumourgenicity and clonogenicity, conferring genomic instability and changes in cell cycle regulation, including resistance to anoikis, as well as resistance to chemotherapeutic agents ( including doxorubicin). [142][143][144][145][146] COX-2 has also been associated with cancer cell migration. [146] Recent data also suggest an intersection of lymphangiogenic growth factor signaling and the prostaglandin pathways in the control of metastatic spread via the lymphatic vasculature.…”

Section: How Nsaids May Influence Cancer Recurrencementioning

confidence: 99%

“…[142][143][144][145][146] COX-2 has also been associated with cancer cell migration. [146] Recent data also suggest an intersection of lymphangiogenic growth factor signaling and the prostaglandin pathways in the control of metastatic spread via the lymphatic vasculature.…”

Section: How Nsaids May Influence Cancer Recurrencementioning

confidence: 99%

Does regional anaesthesia and analgesia or opioid analgesia influence recurrence after primary cancer surgery? An update of available evidence

Ash

Buggy

2013

Best Practice & Research Clinical Anaesthesiology

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Cancer continues to be a key cause of morbidity and mortality worldwide and its overall incidence continues to increase. Anaesthetists are increasingly faced with the challenge of managing cancer patients, either for surgical resection to debulk or excise the primary tumour, surgical emergencies in patients on chemotherapy, or for the analgesic management of disease-or treatmentrelated chronic pain. Metastatic recurrence is a concern. Surgery and a number of perioperative factors are suspected to accelerate tumour growth and potentially increase the risk of metastatic recurrence. Retrospective analyses have suggested an association between anaesthetic technique and cancer outcomes, and anaesthetists have sought to ameliorate the consequences of surgical trauma and minimize the impact of anaesthetic interventions. Just how anaesthesia and analgesia impact cancer recurrence and consequent survival is very topical, as understanding the potential mechanisms and interactions impacts on the anaesthetist's ability to contribute to the successful outcome of oncological interventions . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 ABSTRACT Cancer continues to be a key cause of morbidity and mortality worldwide and its overall incidence continues to increase. Anaesthetists are increasingly faced with the challenge of managing cancer patients, either for surgical resection to debulk or excise the primary tumour, surgical emergencies in patients on chemotherapy, or for the analgesic management of disease-or treatment-related chronic pain. Metastatic recurrence is a concern. Surgery and a number of perioperative factors are suspected to accelerate tumour growth and potentially increase the risk of metastatic recurrence. Retrospective analyses have suggested an association between anaesthetic technique and cancer outcomes, and anaesthetists have sought to ameliorate the consequences of surgical trauma and minimize the impact of anaesthetic interventions. Just how anaesthesia and analgesia impact cancer recurrence and consequent survival is very topical, as understanding the potential mechanisms and interactions impacts on the anaesthetist"s ability to contribute to the successful outcome of oncological interventions.

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“…Indomethacin (IDM) is a nonsteroidal antiinflammatory drug (NSAID) that can exhibit chemoprotective effects against tumors and reduce the risk of colon cancer [9][10][11]. Despite recent advances in NSAIDs formulations, the design of targeted delivery systems to improve the efficacy and reduce side effects of NSAIDs continues to be a focus of much research [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Optimization of a Novel Oral Colon Delivery System of Indomethacin Using Full Factorial Design

Afifi¹,

Mandour²,

Elkhodairy³

2015

Trop. J. Pharm Res

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Indomethacin Inhibits Cancer Cell Migration via Attenuation of Cellular Calcium Mobilization

Cited by 48 publications

References 28 publications

Involvement of L‐type Ca²⁺ channel and toll‐like receptor‐4 in nickel‐induced interleukin‐8 gene expression

Involvement of L‐type Ca²⁺ channel and toll‐like receptor‐4 in nickel‐induced interleukin‐8 gene expression

Does regional anaesthesia and analgesia or opioid analgesia influence recurrence after primary cancer surgery? An update of available evidence

Optimization of a Novel Oral Colon Delivery System of Indomethacin Using Full Factorial Design

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Indomethacin Inhibits Cancer Cell Migration via Attenuation of Cellular Calcium Mobilization

Cited by 48 publications

References 28 publications

Involvement of L‐type Ca2+ channel and toll‐like receptor‐4 in nickel‐induced interleukin‐8 gene expression

Involvement of L‐type Ca2+ channel and toll‐like receptor‐4 in nickel‐induced interleukin‐8 gene expression

Does regional anaesthesia and analgesia or opioid analgesia influence recurrence after primary cancer surgery? An update of available evidence

Optimization of a Novel Oral Colon Delivery System of Indomethacin Using Full Factorial Design

Contact Info

Product

Resources

About

Involvement of L‐type Ca²⁺ channel and toll‐like receptor‐4 in nickel‐induced interleukin‐8 gene expression

Involvement of L‐type Ca²⁺ channel and toll‐like receptor‐4 in nickel‐induced interleukin‐8 gene expression