Antibacterial, Antifungal and Cytotoxic Activities of Two Flavonoids from Retama raetam Flowers

Abstract

We have investigated the antibacterial, antifungal and cytotoxic activities of two flavonoids isolated from Retama raetam flowers using the disc diffusion and micro-dilution broth methods. The cytotoxic activity was tested against Hep-2 cells using the MTT assay. The compounds licoflavone C (1) and derrone (2) were active against Pseudomonas aeruginosa and Escherichia coli (7.81–15.62 µg/mL) and showed important antifungal activity. Strong antifungal activity against Candida species (7.81 µg/mL) was for example found with compound 2. The tested compounds also showed strong cytotoxicity against Hep-2 cells. These two compounds may be interesting antimicrobial agents to be used against infectious diseases caused by many pathogens.

Physicochemical Characteristics Identification and Secondary Metabolite Analysis of Solid Herbal Waste as Source of Feed Rich Fiber and Supplement for Ruminants

“…Flavonoids are known to have antibacterial, anti-fungal and anti-virus activity (Edziri et al, 2012;Andrew et al, 2009), antioxidants (Patra, 2012Harborne, 1973), anti-inflammatory and analgesic effects (Harborne, 1973). In general flavonoids react against microbes by inhibiting microbial cytoplasmic membrane function, inhibits bacterial cell wall synthesis, or inhibit the synthesis of nucleic acids (Chusnie and Lamb, 2011).…”

Isolation and Identification of Active Compounds from Papaya Plants and Activities as Antimicrobial

“…In different bacteria produce different inhibitory power. According to Edziri, et al, [17] gram-positive bacteria have a singlelayer cell wall structure and are composed of peptidoglycan and low-grade lipids (1-4%) so that they are easily penetrated by the flavonoid or alkaloid compounds present in the extract/isolate. While the gram-negative bacteria, has a cell wall structure is layered three and the composition of the cell wall has a high lipid content (11-22%) so difficult to be penetrated by flavonoids or alkaloids contained in polar extract/isolate.…”

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