2019
DOI: 10.3390/cells8091110
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Abstract: Cellular stress response is a universal mechanism that ensures the survival or negative selection of cells in challenging conditions. The transcription factor Forkhead box protein O3 (FOXO3a) is a core regulator of cellular homeostasis, stress response, and longevity since it can modulate a variety of stress responses upon nutrient shortage, oxidative stress, hypoxia, heat shock, and DNA damage. FOXO3a activity is regulated by post-translational modifications that drive its shuttling between different cellular… Show more

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Cited by 134 publications
(88 citation statements)
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References 189 publications
(265 reference statements)
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“…While there were no differences for levels of catalase protein for any of the used conditions ( Figure 4B), there was a significant increase in MnSOD protein level in hTERT overexpressing cells under serum-free conditions with no significant further increase under H 2 O 2 treatment ( Figure 4C). Since MnSOD is a downstream target of Foxo3a, an important transcription factor involved in stress response and longevity (reviewed in [16]) we also analysed protein levels of Foxo3a in MRC-5 cells and their hTERT overexpressing counterparts. Foxo3a protein levels were similar for both cell types under 10% serum in the medium.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…While there were no differences for levels of catalase protein for any of the used conditions ( Figure 4B), there was a significant increase in MnSOD protein level in hTERT overexpressing cells under serum-free conditions with no significant further increase under H 2 O 2 treatment ( Figure 4C). Since MnSOD is a downstream target of Foxo3a, an important transcription factor involved in stress response and longevity (reviewed in [16]) we also analysed protein levels of Foxo3a in MRC-5 cells and their hTERT overexpressing counterparts. Foxo3a protein levels were similar for both cell types under 10% serum in the medium.…”
Section: Resultsmentioning
confidence: 99%
“…There are multiple mtDNA copies per mitochondrium with a variable amount of mitochondria per cell, depending on cell type. Human mitochondrial DNA is a double stranded circular molecule of 16.569 base pairs encoding various transport and ribosomal RNAs as well as 13 proteins involved in oxidative phosphorylation and cellular energy production. Since mtDNA lacks histones and is generally less well repaired than genomic nuclear DNA, mutation frequency of mitochondrial DNA is believed to be substantially higher [11].…”
Section: Introductionmentioning
confidence: 99%
“…In this review, I principally consider the role that FOXOs exert in the nucleus, but FOXOs have also been found to act in the cytoplasm, where they regulate, for example, autophagy [72,73] and ERK activity [74]. FOXOs were also found in the mitochondria [75][76][77].…”
Section: Mechanism Of Actionmentioning
confidence: 99%
“…Our data demonstrate that miR-21 is upregulated in myoblasts treated with IL6 and therefore may mediate IL6-induced FOXO3 activation in myoblasts. FOXO3 has been shown to regulate the cell stress response and apoptotic signaling [64]. Our data show an increase in Gadd45 levels following miR-21 upregulation concomitant with FOXO3 nuclear localisation (Figure 5h,i).…”
Section: Discussionmentioning
confidence: 55%