2021
DOI: 10.3390/ani11082254
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Abstract: : Effective standards of care treatment guidelines have been developed for many canine diseases. However, a subpopulation of patients is partially or completely refractory to these protocols, so their owners seek novel therapies such as treatments with MSCs. Although in dogs, as with human medicine, the most studied MSCs sources have been bone marrow and adipose tissue, in recent years, many researchers have drawn attention towards alternative sources, such as foetal adnexa and fluid, since they possess many a… Show more

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Cited by 2 publications
(2 citation statements)
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“…Moreover, at the time of parturition, when caesarean section is performed, fetal fluids (amniotic and allantoic) can be easily and securely sampled, as demonstrated by many studies [ 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ]. Other than that, the canine fetal fluids were also useful for mesenchymal stem cells isolation and growth as a model of these cell’s biology study and for possible therapeutic application [ 19 , 20 ]. From a hormonal standpoint, canine fetal fluids collected along pregnancy during ovariohysterectomy have been studied also to possibly assess the beginning of thyroid gland function in canine fetuses through the measurement of thyroid hormones [ 21 ] and for a better understanding of the fetal endocrine system development [ 22 ].…”
Section: Introductionmentioning
confidence: 99%
“…Moreover, at the time of parturition, when caesarean section is performed, fetal fluids (amniotic and allantoic) can be easily and securely sampled, as demonstrated by many studies [ 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ]. Other than that, the canine fetal fluids were also useful for mesenchymal stem cells isolation and growth as a model of these cell’s biology study and for possible therapeutic application [ 19 , 20 ]. From a hormonal standpoint, canine fetal fluids collected along pregnancy during ovariohysterectomy have been studied also to possibly assess the beginning of thyroid gland function in canine fetuses through the measurement of thyroid hormones [ 21 ] and for a better understanding of the fetal endocrine system development [ 22 ].…”
Section: Introductionmentioning
confidence: 99%
“…The benefits of these cells compared to adult MSCs are due to their origin from extraembryonic tissues; in fact, because they are at the maternal—foetal interface, these cells present low immunogenicity and immunomodulatory properties, making them a good candidate for allo- and xenotransplantation [ 24 ]. Iacono et al [ 25 ], in their review, observed that, like reported in human and other animal species, also in dog MSCs derived from foetal fluid and adnexa may have an attraction compared to other established SCs in different clinical approaches, although more in vitro studies on their metabolism and clinical applications are needed to fully understand their properties and to establish the future clinical use in the treatment of various diseases. In this contest, Humenik et al [ 26 ] described the effective protocols for the isolation of MSCs from canine bone marrow, adipose tissue, and amnion membrane, showing differences in yield of isolation, morphology, phenotype, multilineage potential, and proliferation activity.…”
mentioning
confidence: 99%