2021
DOI: 10.3389/fphar.2021.659015
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Abstract: Background: The myocardium is susceptible to lipopolysaccharide (LPS)-induced damage in sepsis, and cardiac dysfunction is a leading cause of mortality in patients with sepsis. The changes in cardiomyocyte autophagy in sepsis and the effects and mechanism of action of capsaicin (Cap) remain unclear.Methods and Results: The potential pathway of 14-3-3γ-dependent autophagy and the effects and mechanisms of Cap were studied in LPS-induced injury to primary cultured neonatal rat cardiomyocytes. The results showed … Show more

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Cited by 25 publications
(11 citation statements)
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“…Mice injected with LPS intraperitoneally represent a wellknown animal model of systemic inflammation and cardiac dysfunction. Here, LPS injection decreased the EF and FS, consistent with the findings of previous studies Mou et al, 2021;Qiao et al, 2021). We observed that EA pre-treatment for seven consecutive days increased the EF, FS, and E/A ratio but suppressed the activities of calpain and reduced apoptosis and pro-inflammatory factors in septic mouse hearts.…”
Section: Discussionsupporting
confidence: 93%
See 1 more Smart Citation
“…Mice injected with LPS intraperitoneally represent a wellknown animal model of systemic inflammation and cardiac dysfunction. Here, LPS injection decreased the EF and FS, consistent with the findings of previous studies Mou et al, 2021;Qiao et al, 2021). We observed that EA pre-treatment for seven consecutive days increased the EF, FS, and E/A ratio but suppressed the activities of calpain and reduced apoptosis and pro-inflammatory factors in septic mouse hearts.…”
Section: Discussionsupporting
confidence: 93%
“…We focused on the anti-inflammatory mechanism of acupuncture in septic cardiomyopathy. Accumulating evidence indicates that pro-inflammatory factors are considerably activated in the LPS-injured myocardium ( Okuhara et al, 2017 ; Qiao et al, 2021 ). Here, the expression of cytokines (TNF-α and IL-1β) was upregulated in both serum and cardiac tissues in LPS-induced mouse.…”
Section: Discussionmentioning
confidence: 99%
“…Another study confirmed that capsaicin could minimize mitochondrial dysfunction and was able to protect cardiomyocytes (cells that generate the contractile force in the intact heart) against anoxia/re-oxygenation (A/R)-induced damage and apoptosis [150]. Capsaicin stimulated autophagy by increasing the expression of the 14-3-3 protein, decreasing inflammatory responses caused by oxidative damage, restoring mitochondrial function, and protecting cardiomyocytes from lipopolysaccharide (LPS)-induced destruction [151]. These findings indicate that capsaicin might be effective agent in the prevention of cardiovascular disorders such as atherosclerosis and coronary heart disease.…”
Section: Action Against Cardiovascular Diseasesmentioning
confidence: 91%
“…As previously mentioned [ 20 ], to measure the formation of ROS in acinar cells, the fluorescent probe DCFH-DA (10 μ M, excitation, 488 nm; emission, 505-550 nm) was used. Fresh acinar cells were loaded with DCFH-DA at 37°C in the dark for 20 minutes, washed twice with buffer solution and treated with NaT and VB 12 for the specified time.…”
Section: Methodsmentioning
confidence: 99%