2018
DOI: 10.3389/fmicb.2018.01385
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Abstract: Fusarium culmorum is a fungal pathogen causing economically important diseases on a variety of crops. Fungicides can be applied to control this species with triazoles being the most efficient molecules. F. culmorum strains resistant to these molecules have been reported, but the underlying resistance mechanisms remain unknown. In this study, a tebuconazole-adapted F. culmorum strain was developed with a level of fitness similar to its parental strain. The adapted strain showed cross-resistance to all demethyla… Show more

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Cited by 42 publications
(31 citation statements)
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“…This was also confirmed by using microscopic examination (data not shown). We attempted to use mung bean broth (MBB), which was used for spore production in F. graminearum (Hellin et al, 2018), as a second medium. In this liquid medium, the ΔCgGCS strain produced normal spores, and no morphological defects were observed in the conidia of the wild-type, mutant and complemented strains (Figure 4A).…”
Section: Resultsmentioning
confidence: 99%
“…This was also confirmed by using microscopic examination (data not shown). We attempted to use mung bean broth (MBB), which was used for spore production in F. graminearum (Hellin et al, 2018), as a second medium. In this liquid medium, the ΔCgGCS strain produced normal spores, and no morphological defects were observed in the conidia of the wild-type, mutant and complemented strains (Figure 4A).…”
Section: Resultsmentioning
confidence: 99%
“…RNA sequencing (RNA-seq) technology has become a powerful tool to profile transcriptomic response to reveal azole-resistance mechanism for some pathogenic fungi including prochloraz-resistant P. digitatum [11], voriconazole-resistant A. fumigatus [81], tetraconazoleresistant Cercospora beticola [82], tebuconazole-resistant Fusarium culmorum [83], and fluconazole-resistant Candida glabrata [84]. Our earlier report has elucidated the mechanism of P. digitatum resistance to DMIfungicide prochloraz through RNA-seq analysis [11].…”
Section: (Continued From Previous Page)mentioning
confidence: 99%
“…35,36 This process also includes phase II conjugating enzymes 34,37 and the phase III secretion system, which primarily consists of ABC transporters 38 . The xenobiotic detoxification pathway has not been well characterized in fungi, while most studies on fungicide resistance related to this pathway have focused on efflux activities by ABC transporters, regardless of multidrug 22,39 or DMI resistance 40 . In recent years, a few cases of fungicide resistance due to cytochrome P450-mediated detoxification have been reported, such as fenhexamid resistance resulting from a cytochrome P450 monooxygenase in Botrytis cinerea 41 and fungicide resistance in S. homoeocarpa caused by overexpression of the coding genes of CYP450s and ABC transporters for xenobiotic detoxification.…”
Section: Discussionmentioning
confidence: 99%