2015
DOI: 10.3233/jad-142052
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Abstract: Our results suggest that ACO2 activity is reduced in peripheral lymphocytes of subjects with AD and MCI and correlates with antioxidant protection. Further studies are warranted to verify the role of ACO2 in AD pathogenesis and its importance as a marker of AD progression.

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Cited by 39 publications
(32 citation statements)
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“…Mitochondrial aconitase activity is reduced almost twofold in lymphocytes from AD relative to normal controls (Mangialasche et al ., 2015). ATP synthase α is found on the cell surface of neurons, where it binds oligomeric Aβ to initiate neurotoxicity (Xing et al ., 2013).…”
Section: Discussionmentioning
confidence: 99%
“…Mitochondrial aconitase activity is reduced almost twofold in lymphocytes from AD relative to normal controls (Mangialasche et al ., 2015). ATP synthase α is found on the cell surface of neurons, where it binds oligomeric Aβ to initiate neurotoxicity (Xing et al ., 2013).…”
Section: Discussionmentioning
confidence: 99%
“…Finally, 121 additional papers failed to meet the inclusion criteria. Therefore, this selection resulted in 17 studies that were identified to have as met the rigid inclusion criteria (Figure ).…”
Section: Resultsmentioning
confidence: 99%
“…Mangialasche suggested that low‐plasma vitamin levels were associated with increased odds of AD. Other studies also led to conflicting conclusions. However, owing to differences in the criteria for AD, severity of AD among the different studies, contradictory results for the serum vitamin E levels between patients with AD and healthy controls were obtained.…”
Section: Introductionmentioning
confidence: 99%
“…Cancers are characterized by altered metabolism, and metabolic enzymes, such as ACO2, that show significant differences between cancer and normal cells are attractive molecular targets for cancer treatment. The ACO2 metabolic enzyme has been associated with the development of many diseases, including cancer . We investigated ACO2 protein expression in prostate cancer T and ANT tissues.…”
Section: Discussionmentioning
confidence: 99%
“…Because of the iron‐sulfur group, ACO2 is sensitive to reactive oxygen species (ROS), which can affect ACO2 structure and activity . A decrease of ACO2 activity has been observed in some neurodegenerative diseases and senescence related to oxidative stress . These studies suggest that redox state has a significant effect on the activity of ACO2.…”
Section: Introductionmentioning
confidence: 99%