A Recent Report on ‘Plants with Anti-Candida Properties’

Kumar, Darshan; Ayesha, Ayesha; Jha, Madhulika; Gautam, Pankaj; Joshi, Himanshu; Kumar, N Govind Raj

doi:10.31782/ijcrr.2020.12186

Cited by 4 publications

(3 citation statements)

References 34 publications

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“…The aqueous extract of green tea can decrease the number of viable fungal cells in biofilms formed on acrylic resin [ 82 ]. Specifically, C. sinensis has shown remarkable antifungal activity against Candida spp., for example C. albicans (at an MIC of 0.125 µg/mL), C. parapsilosis (0.125 µg/mL), C. tropicalis (0.125–0.250 µg/mL), and C. glabrata (0.125–0.250 µg/mL) [ 83 ]. Anti-infectious properties have also been demonstrated for tannins isolated from C. sinensis extract [ 84 ].…”

Section: Natural Sources Of Antimicrobial Compoundsmentioning

confidence: 99%

Natural Compounds for Preventing Ear, Nose, and Throat-Related Oral Infections

Niculescu

Grumezescu

2021

Plants

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Oral health is an essential element in maintaining general well-being. By preserving the complex equilibrium within the oral microbial community, commensal microorganisms can protect against extrinsic pathogenic threats. However, when an imbalance occurs, the organism is susceptible to a broad range of infections. Synthetic drugs can be administered to help the body fight against the fungal, bacterial, or viral burden. Nonetheless, they may produce undesirable consequences such as toxicity, adverse effects, and drug resistance. In this respect, research has focused on finding safer and more efficient alternatives. Particularly, increasing attention has been drawn towards developing novel formulations based on natural compounds. This paper reviews the plant-based, algae-based, and beehive products investigated for their antimicrobial properties, aiming to thoroughly present the state of the art on oral infection prevention in the ear, nose, and throat (ENT) field.

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Section: Natural Sources Of Antimicrobial Compoundsmentioning

confidence: 99%

Natural Compounds for Preventing Ear, Nose, and Throat-Related Oral Infections

Niculescu

Grumezescu

2021

Plants

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“…Camellia sinensis and Hypericum havvae possess exceptional anti-Candida properties and can be used for developing alternative antifungal medication. Camellia sinesis has been shown effective against C. albicans, C. parapsilosis, C. tropicalis, and C. glabrata, while Hypericum havvae is a promising agent against C. glabrata, C. kreusei, C. parapsilosis, C. guilliermondii, and C. tropicalis [133].…”

Section: Natural Productsmentioning

confidence: 99%

Biomaterials for the Prevention of Oral Candidiasis Development

et al. 2021

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Thousands of microorganisms coexist within the human microbiota. However, certain conditions can predispose the organism to the overgrowth of specific pathogens that further lead to opportunistic infections. One of the most common such imbalances in the normal oral flora is the excessive growth of Candida spp, which produces oral candidiasis. In immunocompromised individuals, this fungal infection can reach the systemic level and become life-threatening. Hence, prompt and efficient treatment must be administered. Traditional antifungal agents, such as polyenes, azoles, and echinocandins, may often result in severe adverse effects, regardless of the administration form. Therefore, novel treatments have to be developed and implemented in clinical practice. In this regard, the present paper focuses on the newest therapeutic options against oral Candida infections, reviewing compounds and biomaterials with inherent antifungal properties, improved materials for dental prostheses and denture adhesives, drug delivery systems, and combined approaches towards developing the optimum treatment.

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“…Yeasts of the genus Candida are responsible for several infections annually (KUMAR et al, 2020). Moreover, these yeasts have become increasingly resistant to known antifungal drugs, especially azoles, the greater class of antifungal medicine, against Candida (PEREIRA et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Phenological phases and plant tissues of Commiphora leptophloeos influence the antibiofilm activity of Candida spp.

Silva

Siqueira

Lima

2023

Preprint

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Background The plant metabolites production is affected by environmental and biological factors, especially in semiarid environments. Thus, its phonological phase may be an indicator of its phytochemical composition, although studies with this approach are scarce. The objective of this work was to investigate whether changes in the phonological phase of Commiphora leptophloeos influence its antibiofilm potential of Candida spp. Methods We tested ethanol and hexane extracts from leaves and barks of the plant, in two phonological phases, i.e. with leaves and flowers (harvest 1) and with fruits (harvest 2), were tested against three stains: Candida albicans URM 4387, C. krusei URM 6452 and C. tropicalis URM 4262. The effect of the extracts was evaluated in planktonic cells for determination of the Minimum Inhibitory Concentration and the Minimum Fungicidal Concentration using the microdilution technique. We evaluated the extracts effect in biofilm formation and in pre-formed biofilms by colorimetric technique with crystal violet and the cell viability technique with methylene blue. Results All extracts showed inhibitory effect between the concentrations of 2mg/ml and 1mg/ml, as well as fungicidal effect in concentrations equal or higher than 2mg/ml. All the extracts were able to decrease viable cells in the biofilms by more than 50%. There was no synergism between the extracts and Fluconazole. The extracts of the second harvest (fruiting season) showed better results in the activity on the biofilm formation of Candida spp. The extracts of leaf from the first harvest showed higher inhibitory capacity against the pre-formed biofilms, and among the bark extracts, the second harvest was more efficient. The high performance liquid chromatography (HPLC) showed that there was a greater amount of Gallic acid in the bark of C. leptophloeos than in the leaves, with no difference between the harvests for this part of the plant. As for the leaves, the amount of Gallic acid found in the second harvest was higher than that quantified in the first harvest. Conclusions The promising capacity of C. leptophloeos extracts against Candida spp. biofilms is perceived. Furthermore, the results imply that the phenological phases are not the only factor to exert influence on the antibiofilm effect; the part of the plant used should also be taken into consideration.

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A Recent Report on ‘Plants with Anti-Candida Properties’

Cited by 4 publications

References 34 publications

Natural Compounds for Preventing Ear, Nose, and Throat-Related Oral Infections

Natural Compounds for Preventing Ear, Nose, and Throat-Related Oral Infections

Biomaterials for the Prevention of Oral Candidiasis Development

Phenological phases and plant tissues of Commiphora leptophloeos influence the antibiofilm activity of Candida spp.

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