Association of obesity and anovulatory infertility

Fichman, Valéria; Costa, Roseli de Souza Santos da; Miglioli, Teresa Cristina; Marinheiro, Lizanka Paola Figueiredo

doi:10.31744/einstein_journal/2020ao5150

Cited by 17 publications

(11 citation statements)

References 23 publications

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“…The World Health Organization (WHO) concept were followed in this study; people with BMI ≥25 kg/m² are overweight; those with BMI ≥ 30 kg/m² are obese. 8 Infertility which is defined as inability to get pregnant after more than 12 months of unprotected sexual activity, affects 1 in 7 couples worldwide. 9 Obesity leads to disturbances in the hypothalamic pituitary ovarian axis leading to anovulation and infertility.…”

Section: Open Accessmentioning

confidence: 99%

Economic perspective of evaluating fertility treatment in obese and overweight infertile women

Rafique

Al‐Badr

Saleh³

et al. 2021

SMJ

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To evaluate direct cost of in-vitro fertilization/ intracytoplasmic sperm injection (IVF/ICSI) cycle and reproductive outcomes among infertile women with different body mass index (BMI).Methods: A retrospective study of 826 subfertility patients who had IVF or IVF-ICSI in 2017 to 2018 were reviewed. The patients were divided into 4 groups bestowing to BMI to normal weight (18.5-24.9 kg/m 2 ), underweight (<18.5 kg/m 2 ), overweight(25-29.9 kg/m 2 ), and obese(≥30 kg/m 2 ). Data on treatment costs of IVF/ICSI and reproductive outcomes were collected and analyzed. A total of 338 patients (40.9%) were overweight, and 300 (36.3%) patients were obese. A bottom-up methodology was used to measure the resource utilization. The Original Article capital inputs needed for individual procedures were defined and calculated by consulting with appropriate clinicians and priced using market prices for 2017-2018.Results: There was no statistical significant difference for live birth rate (LBR) among the BMI groups, with the occurrence of LBR in 23 women with normal BMI (13.1%), in 48 (14.2%) women who were overweight, in 48 (16%) in women who were obese (p=0.7). The median cost for IVF/ICSI treatment cycle did not differ across BMI groups; the cost was 10,380 SAR for women of normal weight, 10,440 SAR for women who are overweight and obese (p=0.6). Conclusion:Our results suggest that costs of IVF/IVF-ICSI is not significantly affected in women who are overweight or obese.

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Section: Open Accessmentioning

confidence: 99%

Economic perspective of evaluating fertility treatment in obese and overweight infertile women

Rafique

Al‐Badr

Saleh³

et al. 2021

SMJ

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“…Dentro de los efectos de la adiponectina, en relación con la infertilidad, se ha planteado que puede tener acción en la producción de gonadotropinas a nivel del sistema nervioso central y en el ovario regula factores asociados a la ovulación (11). Por lo anterior, aunque un IMC normal sería ideal, una pérdida de peso del 5-10% es beneficiosa, con esta perdida de peso corporal, se logren mejores resultados, que en pacientes con los mismos padecimientos pero que persisten con obesidad o no disminuyen su peso (5,12).…”

Section: Intervenciones No Farmacológicasunclassified

Manejo de infertilidad por anovulación en síndrome de ovario poliquístico

2021

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La infertilidad por anovulación es una complicación común asociada al síndrome de ovario poliquístico. La optimización de la salud constituye el primer paso en el abordaje de esta patología, principalmente con cambios en estilo de vida e índice de masa corporal óptimo. En lo referente a farmacoterapia, el citrato de clomifeno es ampliamente utilizado a nivel mundial como primera línea para inducir la ovulación. No obstante, el letrozol y la metformina en combinación con citrato de clomifeno, son terapias con evidencia prometedora que han demostrado ser superiores al citrato de clomifeno en monoterapia, en lo que respecta a fertilidad. Sin embargo, no existe consenso, y se siguen considerando terapias de segunda línea. Las gonadotropinas exógenas y la perforación laparoscópica del ovario son utilizadas cuando hay resistencia a la primera línea. La fertilización in vitro es una opción cuando tanto la primera, como la segunda línea, no son exitosas. Otros medicamentos se encuentran en estudio para determinar su eficacia en esta patología, como los agonistas del receptor del péptido similar al glucagón tipo 1 y esteroisómeros del inositol, empero, aún requieren estudios de mejor calidad.

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“…Obese women may present with glucose tolerance alterations even without diabetes mellitus, as there is an intermediate stage between glucose homeostasis and diabetes 7 . Insulin resistance may be involved in infertility due to the impact on the frequency and amplitude of the secretion of the luteinizing hormone (LH), which can interrupt follicular growth, generate early luteinization of granulosa cells, and cause damage to oocyte quality.…”

Section: The Impact Of Obesity In Regulating Hormones Involved With the Reproductive Systemmentioning

confidence: 99%

“…Understanding how excessive weight can contribute to infertility is essential to optimize the treatment of this condition, as a woman's nutritional status is a factor that can be modified 7 . Thus, this study aimed to identify a relationship between excessive weight and female infertility and establish how this relationship is based.…”

Section: Introductionmentioning

confidence: 99%

The relationship between overweight and female infertility

Costa¹,

Andrade²,

Soares³

et al. 2021

Rev Cienc Saude

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Excessive weight seems to negatively influence fertility, and as it is a modifiable factor, understanding this relationship can contribute to infertility treatment. Adipose tissue is responsible for releasing several hormones and cytokines related to the reproductive system, such as leptin, TNF-a, and Interleukin-6, substances that can negatively impact female fertility. Additionally, a woman's diet and lifestyle can influence body weight and fertility. Food consumption, characterized by a high intake of foods with high energy density, high levels of sugar, saturated fat, and poor nutrients, as well as physical inactivity, can favor excessive weight. Thus, losing body weight obtained through a healthy diet associated with physical activity may restore fertility in overweight women.

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Association of obesity and anovulatory infertility

Cited by 17 publications

References 23 publications

Economic perspective of evaluating fertility treatment in obese and overweight infertile women

Economic perspective of evaluating fertility treatment in obese and overweight infertile women

Manejo de infertilidad por anovulación en síndrome de ovario poliquístico

The relationship between overweight and female infertility

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