“…In addition, to use dose adjustment software in an efficient manner, some practical limitations observed when carrying out the study should be addressed and discussed, besides those previously presented by Silva et al, ( 1 ) The limitations are difficulty in estimating weight and height in critical patients at intensive care units (ICU), and in these cases, formulas not validated for critical patients are used; lack of confidence to work with DA, for both nursing team, ( 1 ) and prescribers’ team, who routinely use standardized antimicrobial doses recommended by manufacturers; and increased direct costs of medications, due to no intravenous mixture unit available for aseptic dilution, considering the fractionated vials were discarded, which did not contribute to reducing costs in the unit.…”