RETRACTED ARTICLE: Novel drug delivery system based on doxorubicin-encapsulated magnetic nanoparticles modified with PLGA-PEG₁₀₀₀ copolymer

Abstract

New drug delivery systems delivered the active molecules to the target site in a definite manner to produce the desired effects without disturbing the delicate bio-environment. The Fe3O4 magnetic nanoparticles were prepared by chemical precipitation of Fe salts in the ratio of 1:2 under alkaline and inert condition. PLGA-PEG1000 triblock copolymer was synthesized by ring-opening polymerization. The properties of this copolymer were characterized using Fourier transform infrared spectroscopy. In addition, the resulting particles were characterized by X-ray powder diffraction, scanning electron microscopy, and vibrating sample magnetometry. The in vitro doxorubicin (DOX) release profiles were obtained by representing the percentage of DOX release. In this report, we used this new method to fabricate PEGylated PLGA particles, and examined the anticancer agent DOX.

Recent advances on biomedical applications of scaffolds in wound healing and dermal tissue engineering

“…Moreover, hydrophobic polymers did not provide the good environment for the cell-material interactions [119]. Consequently, the surface modification of the polymeric scaffolds should have been considered as an active research area [120,121]. Various methods were being utilized to improve the surface such as incubation time, pH value and pre-treatment using aqueous solution [122].…”

RETRACTED ARTICLE: Preparation and in vitro evaluation of Methotrexate-loaded magnetic nanoparticles modified with biocompatible copolymers

“…The most new global statistics estimate that the number of people suffering from cancer will raise to more than 15 million in 2020 (Avella 2006). Chemotherapy is a common method with the main potential to cure localized and metastasized cancers (Ebrahimi 2014a). Chemotherapy is a useful drug treatment considered to kill cancer cells in individuals with a variety of forms of carcinoma.…”

Magnetic nanoparticles in cancer diagnosis and treatment: a review

“…Magnetic nanoparticles (MNPs) are a most important group of nano-materials with the potential to revolutionize current clinical therapeutic and diagnostic techniques. Apply of nanoparticles based on magnetic in medical uses is a new and highly interdisciplinary field offering great potential in therapeutic and diagnostic testing, in vitro, and in vivo (Ebrahimi 2016a, Tartaj et al 2006. First medical applications used iron powder or magnetite directly in treatment methods.…”