2013
DOI: 10.2478/s11658-013-0094-z
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Microtubules are dynamic polymers that occur in eukaryotic cells and play important roles in cell division, motility, transport and signaling. They form during the process of polymerization of α- and β-tubulin dimers. Tubulin is a significant and heavily researched molecular target for anticancer drugs. Combretastatins are natural cis-stilbenes that exhibit cytotoxic properties in cultured cancer cells in vitro. Combretastatin A-4 (3′-hydroxy-3,4,4′, 5-tetramethoxy-cis-stilbene; CA-4) is a potent cytotoxic cis… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

0
44
1

Year Published

2015
2015
2023
2023

Publication Types

Select...
10

Relationship

0
10

Authors

Journals

citations
Cited by 76 publications
(45 citation statements)
references
References 112 publications
0
44
1
Order By: Relevance
“…Although clinical evaluation of the combretastatins is primarily focused on their pronounced vascular targeting properties, the combretastatins are naturally tubulin-targeting agents and can directly target cancer cells. To date, reviews on this interesting class of compounds have focused on their primary role as VTAs (Tozer et al, , 2008Siemann et al, 2004Siemann et al, , 2009Porcù et al, 2014), strategic chemical modifications (Hsieh et al, 2005;Rajak et al, 2013), their natural origin (Kingston, 2009;Pereira et al, 2012), or their stilbene moiety (Mikstacka et al, 2013). In this work, although acknowledging the former, we also extend our review to include other less conversed, but equally compelling direct anticancer properties endowed by the combretastatins.…”
Section: Vascular Targeting Agentsmentioning
confidence: 86%
“…Although clinical evaluation of the combretastatins is primarily focused on their pronounced vascular targeting properties, the combretastatins are naturally tubulin-targeting agents and can directly target cancer cells. To date, reviews on this interesting class of compounds have focused on their primary role as VTAs (Tozer et al, , 2008Siemann et al, 2004Siemann et al, , 2009Porcù et al, 2014), strategic chemical modifications (Hsieh et al, 2005;Rajak et al, 2013), their natural origin (Kingston, 2009;Pereira et al, 2012), or their stilbene moiety (Mikstacka et al, 2013). In this work, although acknowledging the former, we also extend our review to include other less conversed, but equally compelling direct anticancer properties endowed by the combretastatins.…”
Section: Vascular Targeting Agentsmentioning
confidence: 86%
“…[1][2][3][4][5] Key examples include combretastatins (Chart 1) and resveratrol. 1,6 Combretastatins are strong tubulin polymerization inhibitors binding to the colchicine site and can strongly block tumor growth with a vascular-disrupting effect. 1,[7][8][9] Several derivates of combretastatin A-4 (CA-4) have entered clinical trials.…”
Section: Introductionmentioning
confidence: 99%
“…Angiogenesis has been heavily researched recently as a promising field in anticancer drug development [4,39]. Novel anticancer pharmaceutical products that have relatively few side effects or are non-cytotoxic must be developed, and such products may be obtained from traditional herbal medicines [17,52].…”
Section: Introductionmentioning
confidence: 99%