Comparison between homologous human milk supplements and a commercial supplement for very low birth weight infants

Abstract

Objectives: To describe the methodology for the preparation of two additives derived from human milk, liquid and powdered, and to compare this composition with the commercial additive FM85 ® . Methods:For the preparation of the liquid and powdered supplements, 40 samples of human milk were used. Both supplements have been through three preparation phases: skimming, evaporation and lactose removal. After these phases, the liquid supplement is ready, and the powdered requires a fourth phase -lyophilization. To each sample of the liquid and powdered supplements were added, respectively, 80 mL (group I) and 100 mL (group II) of pooled banked human milk. For comparison, 20 samples of 100 mL of the pool were added to 5 g of the FM85 ® supplement (Nestlé) (group III). Analyses of carbohydrates, protein, lipids, calcium, phosphorus, sodium, osmolality and caloric content were performed, considering a significant difference p < 0.05. Results Conclusion:The studied additives differ significantly from the commercial additive FM85 ® in some of its components, and its composition may or may not meet the quantity of nutrients suggested by the most recent recommendations. J Pediatr (Rio J). 2012;88(2):119-24:Premature infant, enteral nutrition, human milk, milk bank. ResumoObjetivos: Descrever a metodologia de preparo de dois aditivos, líquido e em pó, derivados do leite humano e comparar a constituição com aditivo comercial FM85 ® . Métodos:Foram utilizadas 40 amostras de leite humano para o preparo dos suplementos líquido e em pó. Ambos passaram por três fases de preparo: desnate, evaporação e retirada da lactose. Após essas fases, o suplemento líquido está pronto, e o em pó necessita da quarta fase -a liofilização. Em cada amostra dos suplementos líquido e em pó, foram adicionados, respectivamente, 80 mL (grupo I) e 100 mL (grupo II) de pool de leite humano de banco. Para comparação, 20 amostras de 100 mL do pool foram acrescidas de 5 g do suplemento FM85 ® (Nestlé) (grupo III). Realizaram-se análises de hidratos de carbono, proteína, lipídios, cálcio, fósforo, sódio, osmolalidade e conteúdo calórico, considerando diferença significativa p < 0,05. Conclusão:Os aditivos estudados diferem significativamente do aditivo comercial FM85 ® em alguns de seus constituintes, e a sua constituição pode ou não atender às quantidades de nutrientes propostas pelas recomendações mais recentes. J Pediatr (Rio J)

Factors affecting the catch-up growth of preterm infants after discharge in China: a multicenter study based on the health belief model

“…Furthermore, the results showed that the addition of breast milk supplementation and daily milk volume were factors that affected the catch-up growth of preterm infants after discharge. Breastfeeding has many benefits, but its exclusive use in certain situations can lead to nutrient deficiencies and bone demineralization [19, 20], especially for very and extremely low-birth-weight infants. It has been recognized internationally that fortified breast milk is the best choice of nutrition for preterm infants at present, to meet the baby’s protein, energy and vitamin needs for their catch-up growth [9, 21].…”

The Impact of the Block Freeze Concentration Process on Human Milk Properties Intended for Feeding Newborns

“…The same behavior was observed by Aider, Halleux and Melnikova [36] [38] and by Aider and Ounis [26] in the block freeze concentration of milk products, but only beginning at the third stage of concentration. It is known that human milk provides newborns with proteins whose quality is ideal for their nutrition [6] [11].…”

“…A few human milk based supplements are available on the Market, but their elevated costs may limit their use [3] [11]. Such supplements may be also obtained by submitting human milk to expensive industrial technologies, such as centrifugation [11], evaporation [12], and freeze dry [5].…”

“…Such supplements may be also obtained by submitting human milk to expensive industrial technologies, such as centrifugation [11], evaporation [12], and freeze dry [5]. Despite high-level similarities between human milk and infant formulas, a closer inspection indicates a number of important differences, which may underlie the known nutritional and functional differences between these two sources of infant nutrition [13].…”

Comprehensive literature search and review of breast milk composition as preparatory work for the setting of dietary reference values for vitamins and minerals

“…152 Thomaz, D. M. C., Serafim, P. O. et al (2012). "Comparison between homologous human milk supplements and a commercial supplement for very low birth weight infants."…”