Prevention of atherosclerosis and drug treatment of high-risk lipid abnormalities in children and adolescents

Castro, Priscilla Severino Gonçalves de; Oliveira, Fernanda Luísa Ceragioli

doi:10.2223/jped.1852

Cited by 9 publications

(5 citation statements)

References 48 publications

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“…Therefore, knowing that changes in lipid profile can cause problems for children's health, such as atherosclerosis, early prevention, by adopting and maintaining a healthy lifestyle, is fundamental. 23 …”

Section: Discussionmentioning

confidence: 99%

Dyslipidemia is Associated with Unfit and Overweight-Obese Children and Adolescents

Reuter¹,

Silva²,

Renner³

et al. 2016

Arquivos Brasileiros De Cardiologia

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BackgroundBoth poor aerobic fitness and obesity, separately, are associated with abnormal lipid profiles.ObjectiveTo identify possible relationships of dyslipidemia with cardiorespiratory fitness and obesity, evaluated together, in children and adolescents.MethodsThis cross-sectional study included 1,243 children and adolescents (563 males and 680 females) between 7 and 17 years of age from 19 schools. Obesity was assessed using body mass index (BMI) measurements, and cardiorespiratory fitness was determined via a 9-minute run/walk test. To analyze the lipid profile of each subject, the following markers were used: total cholesterol, cholesterol fractions (high-density lipoprotein and low-density lipoprotein) and triglycerides. Data were analyzed using SPSS v. 20.0, via prevalence ratio (PR), using the Poisson regression.ResultsDyslipidemia is more prevalent among unfit/overweight-obese children and adolescents compared with fit/underweight-normal weight boys (PR: 1.25; p = 0.007) and girls (PR: 1.30, p = 0.001).ConclusionsThe prevalence of dyslipidemia is directly related to both obesity and lower levels of cardiorespiratory fitness.

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Section: Discussionmentioning

confidence: 99%

Dyslipidemia is Associated with Unfit and Overweight-Obese Children and Adolescents

Reuter¹,

Silva²,

Renner³

et al. 2016

Arquivos Brasileiros De Cardiologia

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“…A variety of drugs are available and easily accessible to treat atherosclerosis such as statins, aspirin, blood pressure medications, and other surgical procedures. However, they all have some side effects such as intestinal and stomach bleeding caused by aspirin, whereas the surgical procedure becomes costly for low and middle-income nations to manage the condition [10]- [12]. Therefore, here comes the alternative medicine to rescue which can be cost-effective as well as the having low or no toxicity and side effects.…”

Section: 60% Cardiovascular Diseasesmentioning

confidence: 99%

Molecular Docking Study Reveals α-Santalol from Santalum album Linn. as Promising Inhibitor of CD36 for Atherosclerosis

Sahoo¹,

Sinha²,

Singh³

2022

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Atherosclerosis is an inflammatory vascular disease defined by the increasing buildup of cholesterol in the walls of the arteries, and it is a primary contributor to cardiovascular diseases (CVDs). Issues concerning the adverse effects of synthetic treatments have recently resulted in a lack of patient consultations, drug misuse, and, as a result, a disturbance in meticulous disease control. As a result, a new understanding of traditional medicines has recently developed, and much research has been undertaken on such botanicals in an attempt to produce newer naturally based drugs. Santalum album, commonly known as sandalwood is one of the promising botanicals which is rich in α-Santalol. Therefore, the present study aims at exploring the targeting ability of α-Santalol against the protein CD36 which plays a significant part in the development and progression of atherosclerosis. In this research, a computation approach using Autodock4 is carried out which revealed negative binding energy of 9.10Kcal/mol highlighting the potential of α-Santalol for the effective management of cardiovascular diseases like atherosclerosis. However, there is still a need to validate the findings of this research with both, In Vivo and In Vitro studies.

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“…Atherosclerosis is a major CVDs and it develops itself slowly over the decades and it occurs due to the exposure to risk factors such as dyslipidemia, smoking, hypertension, mellitus diabetes, obesity and emotional stress (SCHOENHAGEN and TUZCU, 2008;CASTRO and OLIVEIRA, 2009). Ignatowski's (1908); was the first to use egg yolk for the induction of atherosclerotic lesions.…”

Section: Introductionmentioning

confidence: 99%

Histopathological and Immunohistochemical studies of the effects of flaxseed in atherosclerosis of rabbits submitted to hypercholesterolemic diet with lyophilized egg to 0.5%

Mattos¹,

Martins²,

Grobe³

et al. 2019

Acervo Saúde

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Objective: The study aimed to evaluate the potential effects of flaxseed in atherogenesis on rabbits submitted to a hypercholesterolemic diet to 0,5% of cholesterol. Methods: The experiment lasted eight weeks and 32 male New Zealand rabbits were randomized into three groups (G1=11, G2=10 and G3=11). All of them received, during the trial period, the diet Nuvilab® increased with 0.5% cholesterol from lyophilized egg. From the 5th to 8th week, in the G2, was added in the hypercholesterolemic diet 8g/kg of crushed flaxseed, totaling an average of 30g/day. The same amount of crushed flaxseed was added since the beginning of the experiment to G3. Blood samples were collected in the beginning and end of the study to analyze total cholesterol, LDL-C, HDL-C and triglycerides. The euthanasia was performed on the sixty-fifth day to remove the aorta. Despite the increase in TC and LDL-C that occurred in the three experimental groups, it was statistically lower in G3. Morphometric analysis of the intima layer showed a statistically significant difference between groups (p=0.030). Results: There was no statistical evidence in immunohistochemical analysis of inflammatory markers. Conclusion: The consumption of crushed flaxseed showed anti-atherogenic effects on the intimal thickening.

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Prevention of atherosclerosis and drug treatment of high-risk lipid abnormalities in children and adolescents

Cited by 9 publications

References 48 publications

Dyslipidemia is Associated with Unfit and Overweight-Obese Children and Adolescents

Dyslipidemia is Associated with Unfit and Overweight-Obese Children and Adolescents

Molecular Docking Study Reveals α-Santalol from Santalum album Linn. as Promising Inhibitor of CD36 for Atherosclerosis

Histopathological and Immunohistochemical studies of the effects of flaxseed in atherosclerosis of rabbits submitted to hypercholesterolemic diet with lyophilized egg to 0.5%

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